Abstract: The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone.
Type:
Grant
Filed:
April 5, 1999
Date of Patent:
February 13, 2001
Assignee:
GelTex Pharmaceuticals, Inc.
Inventors:
W. Harry Mandeville, III, John S. Petersen, Venkata R. Garigapati, Thomas X. Neenan
Abstract: Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
Type:
Grant
Filed:
April 3, 1986
Date of Patent:
April 5, 1988
Assignee:
Fidia, S.p.A.
Inventors:
Francesco Della Valle, Aurelio Romeo, Silvana Lorenzi