Patents Examined by Emily R. Berkeley
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Patent number: 11965068Abstract: Cross-linked polymer networks that are at least partially conjugated (e.g., phenylene vinylene polymer networks). The cross-linked polymer networks may be thin-films disposed on a substrate. The cross-linked polymer network may be covalently bonded to the substrate. The cross-linked polymer networks can be used, for example, in methods of detecting explosives (e.g., RDX (cyclotrimethylenetrinitramine)) and degradation products thereof.Type: GrantFiled: August 20, 2020Date of Patent: April 23, 2024Assignee: Cornell UniversityInventors: William R. Dichtel, Deepti Gopalakrishnan
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Patent number: 11953435Abstract: The invention relates generally to compositions and methods for the detection of zinc. Provided herein is a class of zinc-responsive probes with tunable photophysical properties that can be modified for coupling to a solid support or other chemical moieties. In particular, modifications to the 5-position of the BODIPY core allows for alteration of probe properties and functionalities.Type: GrantFiled: September 25, 2020Date of Patent: April 9, 2024Assignee: Northwestern UniversityInventors: Seth A. Garwin, Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
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Patent number: 11885783Abstract: Compositions, kits, and methods of using the kits and compositions to determine the hardness of and/or magnesium concentration in a solution are described. The kit can include a lyophilized composition that has an absorbance at a detectable wavelength in response to the hardness of the solution and or the concentration of magnesium in the solution.Type: GrantFiled: October 16, 2020Date of Patent: January 30, 2024Assignee: WATER LENS, LLCInventors: Justin M. Dragna, Adam Garland, Tyler West
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Patent number: 11879898Abstract: The teachings herein provide for a method of analyzing testosterone using mass spectrometry. The method entails combining in a vial or well, a tagging reagent that is reactive with testosterone, an aqueous precipitation agent that precipitate proteins from solution, and an internal standard solution, the internal standard solution containing a known concentration of an isotopically enriched testosterone and then adding to the vial or well, a sample containing or suspected to contain testosterone. The vial can then be mixed to cause simultaneous precipitation of proteins and reaction of any testosterone present with the tagging reagent to form a mixture of a precipitate and a liquid solution. The liquid solution can then be separated from any precipitate and then analyzed for testosterone using liquid chromatography tandem mass spectrometry.Type: GrantFiled: December 23, 2019Date of Patent: January 23, 2024Assignee: DH Technologies Development Pte. Ltd.Inventors: Subhakar N Dey, Michal Weinstock
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Patent number: 11866453Abstract: Described are precursor compounds and methods for atomic layer deposition of films containing scandium(III) oxide or scandium(III) sulfide. Such films may be utilized as dielectric layers in semiconductor manufacturing processes, particular for depositing dielectric films and the use of such films in various electronic devices.Type: GrantFiled: October 7, 2022Date of Patent: January 9, 2024Assignee: Intel CorporationInventor: Patricio E. Romero
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Patent number: 11857963Abstract: A microfluidic structure in which a plurality of chambers arranged at different positions are connected in parallel and into which a fixed amount of fluid may be efficiently distributed without using a separate driving source, and a microfluidic device having the same. The microfluidic device includes a platform having a center of rotation and including at least one microfluidic structure. The microfluidic structure includes a sample supply chamber configured to accommodate a sample, a plurality of first chambers arranged in a circumferential direction of the platform at different distances from the center of rotation of the platform, and a plurality of siphon channels, each of the siphon channels being connected to a corresponding one of the first chambers.Type: GrantFiled: November 6, 2020Date of Patent: January 2, 2024Assignee: NEXUS DX, INC.Inventor: Beom Seok Lee
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Patent number: 11860172Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. Due to the use of a liquid phase that does not destroy native tissue morphology during analysis, a subsequent staining technique can be performed on the tissue sample and an overlaid image can be produced of a mass spectral image and a staining image.Type: GrantFiled: May 26, 2021Date of Patent: January 2, 2024Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Livia Schiavinato Eberlin, Christina Ramires Ferreira, Allison Lisa Dill, Demian R. Ifa
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Patent number: 11819840Abstract: A pipette tip for and method of automatically maintaining pipette tip depth in a fluid during a fluid transfer operation is disclosed. The pipette tip includes, for example, two electrodes that run substantially the full length of the pipette tip for measuring the resistance therebetween when submerged in a conductive fluid. A method is provided of automatically maintaining the depth of the pipette tip in a liquid throughout a pipetting operation, as the liquid surface rises or falls in its container, without any prior knowledge of the container geometry.Type: GrantFiled: December 20, 2018Date of Patent: November 21, 2023Assignee: FORMULATRIX, INC.Inventors: David Wikholm, Rasmus Lindblom
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Patent number: 11795449Abstract: This disclosure relates to a nucleic acid collection column that collects a nucleic acid from a liquid sample containing the nucleic acid. The nucleic acid collection column includes a sample injection portion having an opening into which the liquid sample containing the nucleic acid is injected, a support adsorption portion that houses a support for adsorbing the nucleic acid and in which the nucleic acid is adsorbed on the support, and a discharge portion that discharges a liquid passed through the support adsorption portion. The support includes aluminum oxide having a surface where a water-soluble neutral polymer is adsorbed. A space that houses the support in the support adsorption portion has a cylindrical shape, and has a volume of 0.13 ?L or more and 13.5 ?L or less. An aspect ratio (d1/d2) of the space satisfies 1.0?d1/d2<15.0.Type: GrantFiled: October 30, 2019Date of Patent: October 24, 2023Assignee: Toray Industries, Inc.Inventors: Shota Sekiguchi, Takahiro Motoshiromizu, Masateru Ito
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Patent number: 11779901Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.Type: GrantFiled: April 21, 2022Date of Patent: October 10, 2023Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: R. Andrew McGill, Courtney A. Roberts
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Patent number: 11747310Abstract: Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.Type: GrantFiled: October 25, 2019Date of Patent: September 5, 2023Assignee: Waters Technologies CorporationInventors: Michael F. Morris, Matthew A. Lauber, Darryl W. Brousmiche
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Patent number: 11739261Abstract: A fluorescent compound for acid detection is strongly emissive in the solid state and can aggregate in the presence of an acid. As such, a fluorescent intensity emitted from the compound can be enhanced from an original intensity level in the presence of an acid. The fluorescent compound can emit an enhanced fluorescent intensity in the presence of an ultra-low acid concentration, for example, a concentration of at least about 10?20 M.Type: GrantFiled: January 13, 2020Date of Patent: August 29, 2023Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Benzhong Tang, Xin Cai, Jianguo Wang
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Patent number: 11740235Abstract: An assay system for measuring transfer of lipid from a donor model biomembrane to an acceptor model biomembrane generally includes a donor model biomembrane that has a lipid with a detectable label, a lipid transfer protein that specifically binds the detectable lipid, and an acceptor model biomembrane. At least one of the donor model biomembrane and the acceptor model biomembrane is a bicelle-dilution model membrane.Type: GrantFiled: August 20, 2020Date of Patent: August 29, 2023Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Rhoderick Edmiston Brown, Jr., Yong-guang Gao
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Patent number: 11738327Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.Type: GrantFiled: April 21, 2022Date of Patent: August 29, 2023Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: R. Andrew McGill, Courtney A. Roberts
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Patent number: 11685741Abstract: The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.Type: GrantFiled: February 1, 2018Date of Patent: June 27, 2023Assignee: University of MassachusettsInventor: Maolin Guo
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Patent number: 11674935Abstract: A composition, method and kit for quantifying the concentration of one peracid or the total concentration of two or more peracids in a water source are disclosed. In particular, an oxidation sensitive or peroxycarboxylic acid selective leuco dye is used to react only with one or more peroxycarboxylic acids in a water source but not with peroxide usually co-existing in the water source. Not only does the oxidation sensitive or peroxycarboxylic acid selective leuco dye react with peracid(s) but also the reaction generates a color species that can be used visually or through absorbance measurement to quantify the peracid concentration. The method disclosed here is not a titration method, it involves a simple mixing step. The kit or composition disclosed here does not utilize a catalyst, such as iodine.Type: GrantFiled: November 12, 2020Date of Patent: June 13, 2023Assignee: ECOLAB USA INC.Inventors: Ramakrishnan Balasubramanian, Junzhong Li
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Patent number: 11656159Abstract: The present invention relates to a clearing technique which uses a solution containing at least one of a compound having a delipidation ability, a compound having a biochrome decoloring ability, a compound having a decalcification ability, a compound having a refractive index adjusting ability, and a compound having a tissue swelling ability. The clearing technique is suitable for use in high-throughput and low-magnification imaging which involves a simple process.Type: GrantFiled: April 25, 2017Date of Patent: May 23, 2023Assignee: RIKENInventors: Hiroki Ueda, Kazuki Tainaka, Tatsuya Murakami
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Patent number: 11654415Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.Type: GrantFiled: April 21, 2022Date of Patent: May 23, 2023Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: R. Andrew McGill, Courtney A. Roberts
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Patent number: 11649253Abstract: The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule.Type: GrantFiled: July 5, 2018Date of Patent: May 16, 2023Assignees: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Amandine Roux, Anh-Thy Bui, Olivier Maury, Chantal Andraud
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Patent number: 11648529Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.Type: GrantFiled: April 21, 2022Date of Patent: May 16, 2023Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: R. Andrew McGill, Courtney A. Roberts