Patents Examined by Emma Cech
  • Continuous selective clonogenic expansion of relatively undifferentiated cells
    Patent number: 5674750
    Abstract: A system is provided for selective clonogenic expansion of relatively undifferentiated cells, including (a) a tube containing a plurality of beads of a size which permits a plurality of the undifferentiated cells to grow thereon, the beads bearing on their surfaces a selective binding molecule which binds to a surface antigen present on the relatively undifferentiated cells, wherein the antigen is not present on the surfaces of the relatively differentiated cells; (b) means for continuously providing nutrients to the relatively undifferentiated cells growing on the beads, wherein the nutrients are delivered via a fluid which flows through the tube and past the beads; and (c) means for continuously harvesting the relatively undifferentiated cells downstream of the beads.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 7, 1997
    Assignee: t. Breeders
    Inventors: Morey Kraus, Jill Friberg
  • Recovery of taxanes from conifers
    Patent number: 5670663
    Abstract: The present invention provides new sources of taxanes and other metabolites from members of the order Coniferales that are not in the genus Taxus.
    Type: Grant
    Filed: February 14, 1996
    Date of Patent: September 23, 1997
    Assignee: Regents of the University of California
    Inventors: Don J. Durzan, Frank Ventimiglia
  • BBC6 gene for regulation of cell death
    Patent number: 5663316
    Abstract: The subject invention provides new proteins which are involved in the regulation of cell death. Also provided are nucleotide sequences which encode the novel proteins. Further aspects of the invention include antibodies to the novel proteins, and diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: September 2, 1997
    Assignee: Clontech Laboratories, Inc.
    Inventor: Yin Xudong
  • Immunochemical isolation of in vivo advanced glycosylation endproducts
    Patent number: 5629408
    Abstract: The circulating advanced glycosylation endproducts Hb-AGE, serum AGE-peptides and urinary AGE-peptides are disclosed as long term markers of diseases and dysfunctions having as a characteristic the presence of a measurable difference in AGE concentration. Diagnostic and therapeutic protocols taking advantage of the characteristics of these AGEs are disclosed. Antibodies which recognize and bind to in vivo-derived advanced glycosylation endproducts are also disclosed. Methods of using these antibodies as well as pharmaceutical compositions are also disclosed, along with numerous diagnostic applications, including methods for the measurement of the presence and amount of advanced glycosylation endproducts in both plants and animals, including humans, as well as in cultivated and systhesized protein material for therapeutic use.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 13, 1997
    Assignee: The Rockefeller University
    Inventor: Richard J. Bucala