Abstract: A solid dosage form for oral administration to a patient comprising a core tablet sheathed in an annular body of compressed powder or granular material is provided. A preferred embodiment of the solid dosage form reduces contact of the active ingredient in solid form with the mucosa lining the gastrointestinal tract, which is particularly advantageous for delivering an ulcerative drug. A tool set comprising a columnar punch and a punch assembly comprising an annular punch and core rod, and a tableting process for making the solid dosage form are also provided.
Type:
Grant
Filed:
April 21, 2003
Date of Patent:
November 3, 2009
Assignee:
Teva Pharmaceutical Industries Ltd.
Inventors:
E. Itzhak Lerner, Vered Rosenberger, Ofer Aqua, Moshe Fleshner-Barak
Abstract: Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.
Type:
Grant
Filed:
March 28, 2002
Date of Patent:
September 15, 2009
Assignee:
Starpharma Pty. Ltd.
Inventors:
Barry Ross Matthews, George Holan, Peter Karellas, Scott Andrew Henderson, David Francis O'Keefe
Abstract: Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are described. In one form each of the controlled release ceramic particles has an active material(s) substantially homogeneously dispersed throughout the particles, wherein the active material(s) is capable of being released from said particles, and the active material(s) in said particles is substantially protected from degradation until release of the active material(s) from the particles.
Type:
Grant
Filed:
July 11, 2008
Date of Patent:
September 8, 2009
Assignee:
Australian Nuclear Science & Technology Organisation
Inventors:
Christophe Jean Alexandre Barbé, John Bartlett
Abstract: The present invention provides exemplary systems and methods for producing dry powder formulations. In one embodiment, a system (10) includes at least one conditioning zone (12) having an inlet (20) to introduce an atomized formulation (18) into the conditioning zone. A controller (14, 16) controls temperature and relative humidity of the airflow into the conditioning zone to allow amorphous-to-crystalline transformation of the atomized formulation. In another embodiment, the formulation is suspended in the conditioning zone for a residence time of sufficient duration to allow surface orientation of surface active components. A dryer (24) is coupled to the conditioning zone to dry the atomized formulation, and a collector (28) collects the formulation in powder form.
Type:
Grant
Filed:
December 8, 2000
Date of Patent:
August 18, 2009
Assignee:
Novartis Pharma AG
Inventors:
David B. Bennett, Thomas K. Brewer, Robert M. Platz, Herman Snyder
Abstract: A design strategy for constructing hierarchically structured materials using nanoparticles and synthetic biopolymers has been developed. Block copolypeptides or homopolymer polyelectrolytes are used as structure-directing agents to arrange nanoparticles (composed of metals, metal non-oxides, metal oxides, or organics) into unusual microstructures, such as spheres, “apples” and “cups.” Hollow spheres can be made wherein nanoparticles of one composition are spatially oriented completely interior or exterior to nanoparticles of a second composition. These aggregates contain nanoparticles only in the shell walls, and maintain their hollowness upon calcination. These shapes can also be fabricated into films. These robust materials are anticipated to have great promise in applications that require surface catalysis, magnetic/electronic/optic properties, transport capabilities, and combinations thereof, such as drug delivery, packaging, catalysis, and sensors.
Type:
Grant
Filed:
October 2, 2002
Date of Patent:
July 21, 2009
Assignee:
The Regents of the University of California
Inventors:
Jennifer Cha, Timothy J. Deming, Galen D. Stucky, Michael Wong, Henrik Birkedal, Michael H. Bartl, Jan L. Sumerel
Abstract: Process for the preparation of programmed liberation compositions with venlafaxine and the resulting product, from which the resulting product allows a better absorption of the active principle and a drastic decrease of the adverse effects, due to the preparation methodology. The formulation comprises a first phase, in which the non-active cores are elaborated as spherical micro granules, from sugar and starch. In the second phase, it is added to them the active drug, as impalpable powder, utilizing as binding, a povidone alcoholic solution. In the third phase, it is applied the coating on the micro granules that contain the active drug. At last, in the fourth phase, it is made the encapsulation of the recoated micro granule.
Type:
Grant
Filed:
January 3, 2002
Date of Patent:
July 21, 2009
Inventors:
Fernando Rafael De Souza, Elizabeth Molenda Ferreira Amado
Abstract: A clathrate formed by: a hyaluronic acid derivative (a), a hyaluronic acid derivative (b1) different from (a), and being able to form a clathrate with (a) and/or a component (b2) not containing a hyaluronic acid moiety but being able to form with (a) a clathrate and its use in the pharmaceutical field.
Type:
Grant
Filed:
March 12, 2001
Date of Patent:
July 21, 2009
Assignee:
Italian Joint Stock Company
Inventors:
Ladislav Soltes, Bohumil Steiner, Eva Machova, Grigorij Kogan, Slavomir Bystricky, Raniero Mendichi, Viktor Bauer, Mojmir Mach, Juraj Alfordi, Eva Stratilova
Abstract: The invention relates to a composition for topical use containing, in a physiologically acceptable medium having an aqueous phase, at least one oxidation-sensitive hydrophilic active principle and at least one non-crosslinked N-vinylimidazole polymer or copolymer, the active principle and the said polymer or copolymer both being in the aqueous phase.
Abstract: A polymeric composition comprising a polysulfone polymer and an elastomeric polymer for use as a coating composition for coating an implantable device, such as a DES, and methods of making and using the implantable device are provided.
Type:
Grant
Filed:
November 25, 2003
Date of Patent:
July 14, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Charles D. Claude, Ni Ding, Yeung Siu Yu
Abstract: A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium. The present invention also provides an efficient method to effectively incorporate a hydrophobic drug into a polymeric micelle in a polyethylene glycol separating medium.
Abstract: This invention relates to certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including Molybdenum, complexed concurrently with an amino acid, or an equivalent of an amino acid, and a hydroxy acid in a novel spirocyclic bidentate chemical complex form (FIG. 1). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation. The said metal complexes are useful for topical conditions that include dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, age spots, dark circles around eyes, skin pigmentation, topical inflammation, liver spots, pigmented spots, wrinkles, blemishes, skin lines, oily skin, acne, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, disturbed keratinization, dandruff, bacterial infection, fungal infection, wound healing, body odor, and skin changes associated with aging.
Abstract: The present invention provides a light-activated adhesive composite suitable for medical and surgical applications. The composite includes a scaffold and a light-activated adhesive, such as a laser tissue solder. The scaffold includes a biological, biocompatible, or biodegradable material, such as PLGA or SIS.
Type:
Grant
Filed:
January 15, 2004
Date of Patent:
March 10, 2009
Assignees:
Rose-Hulman Institute of Technology, The Board of Trustees of the University of Illinois
Inventors:
Karen M. McNally-Heintzelman, Douglas L. Heintzelman, Jeffrey N. Bloom, Mark T. Duffy
Abstract: A composition comprising lidocaine-containing liposomes wherein the weight concentration of lidocaine in said composition is greater than 10%. The composition is prepared by mixing water with an oil phase comprising lidocaine, a C14-C20 alcohol, an alkyl ester of a fatty acid, propylene glycol, and a polyalkyl stearate. The non-aqueous phase may also include a phospholipid such as phosphatidyl choline.
Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
Type:
Grant
Filed:
December 6, 2005
Date of Patent:
December 2, 2008
Assignee:
Genzyme Corporation
Inventors:
Stephen Randall Holmes-Farley, W. Harry Mandeville, III, George M. Whitesides
Abstract: The present invention discloses cosmetic transparent hair removal (depilatory) compositions that: (1) Are transparent in appearance, (2) Can be made in cold wax or hot wax forms, (3) Manufactured at much less than 80 ° C., (4) Three-dimensional particles of visually attractive compositions can be added, (5) Bind more strongly with hair and less strongly with skin, (6) Can be applied either directly on the skin or applied on a piece of fabric, plastic, or paper first, which is then applied to skin for hair removal, and (7) Require minimal clean-up.
Abstract: A topical gel matrix that can be used alone or combination with a medication entrapped therein. The gel matrix is dispersible in water. The gel may have the following composition: oil, water or aqueous solution; solvents, surfactants and/or detergents; and a polymer which is a consistence modifier capable of thickening and to resist degradation in a water environment. The matrix may comprise or not a biologically active ingredient for a systemic or topical indication. Amongst preferred medications are anaesthetic, anti-histaminic, anti-inflammatory, anti-oxidant, anti-UVs, anti-microbial and wound healing agents. More specifically, for the treatment of fish infections, examples of preferred active ingredients are natural or synthetic plants extracts.
Type:
Grant
Filed:
October 15, 2003
Date of Patent:
October 21, 2008
Assignee:
Rolf C. Hagen, Inc.
Inventors:
Anthony Costa, Benoit Choquet, Yvan Giguère
Abstract: The present invention relates to the treatment of gastrointestinal disease and/or cancer, and a method of weight gain, via the ingestion of polymeric compositions in humans, animals or birds in need of said treatment. The invention provides methods for the treatment of cancer, the treatment and/or prevention of gastrointestinal disease and/or infection and/or diarrhoea, and a method for increasing weight gain in humans, animals or birds comprising administering to said humans, animals or birds an effective amount of a pharmaceutical or veterinary composition, or feed additive, comprising an effective amount of a polymer and/or copolymer, having the repeating polymeric unit (I), wherein R is H or alkyl, usually C1 to C4, or this unit in hydrated, hemiacetal or acetal form, together with a pharmaceutically or veterinarally acceptable carrier, diluent, adjuvant, excipient and/or controlled release system.
Abstract: The use of a dietary fiber or a mixture of dietary fibers for the manufacture of a composition, being a pharmaceutical composition or a functional food or a functional feed, for the prevention, the inhibition and/or the treatment of systemic infections in humans and in vertebrates caused by pathogenic bacteria is disclosed. A method for the prevention, the inhibition and/or the treatment of systemic infections in humans and in vertebrates caused by pathogenic bacteria, comprising administration to said beings, orally, through tube feeding or rectally, a composition containing an effective amount of a dietary fiber or mixture of dietary fibers is also disclosed. The dietary fiber is preferably a fructan, typically inulin and/or oligofructose, most preferably chicory inulin with an average degree of polymerization (DP) of at least 20.
Type:
Grant
Filed:
September 28, 2000
Date of Patent:
October 7, 2008
Assignees:
Mississippi State University, Tiense Suikerraffinaderij N.V.
Inventors:
Randal K. Buddington, Jan Van Loo, Anne Frippiat
Abstract: Water soluble, gelatin-free dip coatings for substrates comprising an acrylic film former; a paraben plasticizer; and a secondary plasticizer such as polyvinylpyrrolidone, polyethylene glycol 300, polyethylene glycol 400 or mixtures thereof.
Abstract: The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly poly (N-(2-hydroxypropyl)methacrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention, comprise monomers which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.
Type:
Grant
Filed:
March 18, 2004
Date of Patent:
September 16, 2008
Assignee:
Universiteit Utrecht
Inventors:
Wilhelmus Everardus Hennink, Cornelus Franciscus Van Nostrum, Marinus Jacob Van Steenbergen, Osamu Soga