Patents Examined by Evelyn Mei Huang
  • Useful aroyl pyrrole heteroaryl methanones and methanols
    Patent number: 6897319
    Abstract: This invention is directed to aroyl pyrrole heteroaryl methanone and methanol compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: May 24, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John R. Carson, Ellen E. Codd, Philip M. Pitis
  • Biphosphonate conjugates and methods of making and using the same
    Patent number: 6896871
    Abstract: The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: May 24, 2005
    Assignee: MBC Research, Inc.
    Inventors: Alexander Karpeisky, Nelly Padioukova, Sergey Mikhailov, H.B.F. Dixon, Grigorii Tzeitline, Marat Karpeisky
  • Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
    Patent number: 6897224
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I a process for their production and their use as inflammation inhibitors.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: May 24, 2005
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schäecke, Arndt. J. G. Schottelius
  • Industrial process for preparing tropenol
    Patent number: 6891042
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: May 10, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands
    Patent number: 6887885
    Abstract: A compound of formula I, or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen; Y represents a chemical bond, an oxygen atom, or a —NH— linkage; Z represents an optionally substituted aryl or heteroaryl group; R1 represents hydrocarbon, a heterocyclic group, trifluoromethyl, —SO2Ra, —SO2NRaRb, —CORa, —CO2Ra or —CONRaRb; and Ra and Rb independently represent hydrogen, hydrocarbon or a heterocyclic group; pharmaceutical compositions including the compound and methods for treating anxiety, convulsions and cognitive disorders are disclosed.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: May 3, 2005
    Assignee: Merck Sharp & Dohme Ltd
    Inventor: Simon Charles Goodacre
  • Sulfonamide and sulfamide substituted imidazoquinolines
    Patent number: 6888000
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: May 3, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
  • 6-heteroarylphenanthridines
    Patent number: 6884802
    Abstract: Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyradazinyl radical, or an unsubstituted or R6- and/or R7-substituted fused bi- or tricyclic ring system comprising at least one aromatic ring and up to 4 heteroatoms-selected from the group consisting of O (oxygen), S (sulfur), N (nitrogen)- which is bonded to the phenanthridinyl radical via one of the rings comprising one or more heteroatoms, are active PDE4 inhibitors.
    Type: Grant
    Filed: July 7, 2001
    Date of Patent: April 26, 2005
    Assignee: ALTANA Pharma AG
    Inventor: Beate Schmidt
  • Inhibitors of ?-lactamase
    Patent number: 6884791
    Abstract: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel ?-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ?-lactamase inhibitors presently available, and which do not require a ?-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: April 26, 2005
    Assignee: MethylGene, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Arkadii Vaisburg
  • 3-substituted quinuclidines and their use as nicotinic agonists
    Patent number: 6884807
    Abstract: This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: April 26, 2005
    Assignee: Neurosearch, A/S
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Philip K. Ahring, Tino Dyhring Jørgensen
  • 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents
    Patent number: 6878705
    Abstract: The invention provides a compound of formula I: wherein G, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: April 12, 2005
    Assignee: Pfizer
    Inventors: Michele M. Cudahy, Mark E. Schnute, Steven P. Tanis, William R. Perrault, Paul Matthew Herrinton, Sajiv K. Nair
  • Indole derivative having heterocycle and mono- or diazaindole derivative
    Patent number: 6875770
    Abstract: There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A1 and A2 each independently represent —CH?, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH?, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: April 5, 2005
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroharu Matsuoka, Nobuaki Kato, Tadakatsu Takahashi, Noriaki Maruyama, Takenori Ishizawa, Yukio Suzuki
  • Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
    Patent number: 6872730
    Abstract: The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (?v) integrins, for example ?v?3 and ?v?5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by ?v?3 and ?v?5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula I: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, n, i, j and k are defined herein.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: March 29, 2005
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Beth M. Anaclerio, Juan J. Marugan Sanchez, Victor J. Marder, David C. U'Prichard, Bruce E. Tomczuk
  • Compounds for generating chemiluminescence with a peroxidase
    Patent number: 6872828
    Abstract: Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: March 29, 2005
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Renuka de Silva, Wenhua Xie
  • Antitumor agents
    Patent number: 6867219
    Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: March 15, 2005
    Assignee: Wayne State University
    Inventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
  • Preparation of beta quinacridone pigments
    Patent number: 6864371
    Abstract: A novel method for the preparation of a beta quinacridone pigment is described by the oxidation of 6,13-dihydroquinacridone in the presence of polyvinyl pyrrolidone, a catalyst and optionally a particulate quinacridone or particle growth inhibitor using hydrogen peroxide as the oxidant.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: March 8, 2005
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Fridolin Bäbler
  • Process for the preparation imidazo[1,2-A]pyridine-3-acetamides
    Patent number: 6861525
    Abstract: The present invention relates to an improved synthesis of imidazo[1,2-a]pyridine-3-N,N-dialkylacetamides, including zolpidem tartrate.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: March 1, 2005
    Assignee: Scinopharm Taiwan, Ltd.
    Inventor: George C. Schloemer
  • DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds
    Patent number: 6858742
    Abstract: The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also relates to a process of preparing DNA labeling compound.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: February 22, 2005
    Assignee: AsiaGEN Corporation
    Inventors: George Chin-Sheng Chou, Yu-Cheng Wu, Po-Ya Hsu
  • Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
    Patent number: 6858613
    Abstract: The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat conditions or diseases in which ?7 is known to be involved.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: February 22, 2005
    Assignee: Pfizer Inc.
    Inventors: Bruce N. Rogers, David W. Piotrowski, Daniel Patrick Walker, Eric Jon Jacobsen, Brad A. Acker, Donn G. Wishka, Vincent E. Groppi, Jr.
  • Potassium channel inhibitors
    Patent number: 6858611
    Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: February 22, 2005
    Assignee: Icagen, Inc.
    Inventors: Aimee Dolores Reed, Michael Francis Gross, Serge Beaudoin
  • Compounds for generating chemiluminescence with a peroxidase
    Patent number: 6858733
    Abstract: Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: February 22, 2005
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Renuka de Silva, Wenhua Xie