Abstract: A capacitive microfabricated ultrasonic transducer with control of elevation phase through alternating bias polarity is disclosed. Such control of elevation phase results in simple ultrasonic probes with excellent slice thickness attributes. Furthermore, tight spatial variation of phase results in an effective way to achieve transmit aperture and apodization control. Further still, such capacitive microfabricated ultrasonic transducers can achieve elevation focus without the need of a lossy mechanical lens.

Abstract: A system and method for assigning feature sensitivity values to a set of potential measurements to be taken during a medical procedure of a patient in order to provide a medical diagnosis is disclosed. Data is received from a sensor that represents a particular medical measurement. The received data and context data are analyzed with respect to one or more sets of training models. Feature sensitivity values are derived for the particular medical measurement and other potential measurements to be taken based the analysis, and the feature sensitivity values are outputted.

Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.

Abstract: The present invention is generally directed towards an imaging transducer assembly. Generally, the imaging transducer assembly is combined with a sensor of a medical positioning system. In one aspect, the transducer assembly and the sensor share the same voltage source. In another aspect of the invention, the sensor surrounds a portion of the imaging transducer assembly, forming a housing that reinforces the assembly.

Abstract: An ultrasonic imaging catheter apparatus and a method of using the same to scan the inner wall of a body lumen. The ultrasonic imaging catheter apparatus comprises: (a) a flexible elongate element adapted for insertion into a body lumen, the elongate element having distal and proximal ends; (b) an ultrasonic transducer generating and detecting ultrasonic energy disposed proximate the distal end of the elongate element; (c) a reflective member disposed proximate the ultrasonic transducer and optionally rotatable with respect to an axis of the body lumen, wherein the reflective member is adapted to reflect (i) ultrasonic energy generated by the ultrasonic transducer to a wall of the body lumen and (ii) ultrasonic energy reflected by the wall back to the transducer; and (d) an actuator, for example, an electroactive polymer actuator, adapted to change the angle of incidence of the ultrasonic energy relative to the reflective member.

Abstract: An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. A method to estimate a strain rate in any direction, not necessarily along the ultrasound beam, based on tissue velocity data from a small region of interest around a sample volume is disclosed. Quantitative tissue deformation parameters, such as tissue velocity, tissue velocity integrals, strain rate and/or strain, may be presented as functions of time and/or spatial position for applications such as stress echo. For example, strain rate or strain values for three different stress levels may be plotted together with respect to time over a cardiac cycle.

Abstract: An ultrasound imaging system has an ultrasound probe adapted to be placed in an instrument working channel of an endoscope, the ultrasound probe having a probe housing; an ultrasound transducer mounted within the probe housing; and an elongate flexible cord extending from the probe housing, the elongate flexible cord being adapted to fit through the instrument working channel of the endoscope and operably connect the ultrasound transducer with a computer.

Abstract: A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image.

Abstract: High resolution B-mode ultrasound images of the common carotid artery are obtained with an ultrasound transducer using a standardized methodology. Subjects are supine with the head counter-rotated 45 degrees using a head pillow. The jugular vein and carotid artery are located and positioned in a vertical stacked orientation. The transducer is rotated 90 degrees around the centerline of the transverse image of the stacked structure to obtain a longitudinal image while maintaining the vessels in a stacked position. A computerized methodology assists operators to accurately replicate images obtained over several spaced-apart examinations. The methodology utilizes a split-screen display in which the arterial ultrasound image from an earlier examination is displayed on one side of the screen while a real-time “live” ultrasound image from a current examination is displayed next to the earlier image on the opposite side of the screen.

Abstract: The present invention discloses an ultrasound imaging system and method based on simultaneous multiple transmit-focusing using the weighted orthogonal chirp signals so that resolution of an ultrasound image is enhanced without sacrifice in the frame rate.

Abstract: A method for ablating tissue with ultrasonic energy is provided. The method including: generating ultrasonic energy from one or more ultrasonic transducers; and focusing the ultrasonic energy in the radial direction by one of: shaping the one or more ultrasonic transducers to focus ultrasonic energy in the radial direction; and arranging one or more lenses proximate the one or more ultrasonic transducers for focusing the ultrasonic energy from the one or more ultrasonic transducers in a radial direction.

Abstract: Ultrasonic probe devices are provided which are particularly suitable for use as invasive imaging probes such as endocavity probes and endoscopic probes. The probe devices include a dual cross-scanning bi-plane array transducer formed by a pair of orthogonal, intersecting transducer arrays. The probe devices are capable of providing, either simultaneously or alternately, crossing scanning through a single symmetrical scanning axis.

Abstract: A system and method for ultrasonic harmonic imaging. The ultrasonic harmonic imaging system comprises a wideband phased-array transducer, a transmitter for transmitting waves into the tissue, a portion of which is at a fundamental frequency and a portion of which is at a harmonic of the fundamental frequency, a receiver for receiving ultrasonic responses from the tissue, a control system electrically coupled to the transmitter and the receiver for controlling operation of the transmitter and receiver, a video processor, and a monitor.

Abstract: A method and system providing control of an ultrasound system with a user interface is provided. The user interface for controlling the ultrasound system includes a plurality of selectable elements for controlling operation of the ultrasound system and a plurality of identifiers. Each identifier corresponds to one of the plurality of selectable elements and associates control commands with the selectable elements.

Abstract: A system for developing an ultrasound image, comprises a scan head having a transducer capable of generating ultrasound energy at a frequency of at least 20 megahertz (MHz), and a processor for receiving ultrasound energy and for generating an ultrasound image at an effective frame rate of at least 200 frames per second (fps) using scan line based image reconstruction.

Abstract: To reduce the cost while maintaining the real time environment in receiving ultrasonic waves in an ultrasonic receiving apparatus which is capable of reducing changes in detection sensitivity due to environmental changes in the ultrasonic detecting element. The ultrasonic receiving apparatus comprises a light source for generating broadband light, an ultrasonic detecting element including an ultrasonic sensing portion that expands and contracts in response to a received ultrasonic wave and has optical reflectance that changes in accordance with expansion and contraction thereby performing intensity modulation on the light, spectrum-separating means for spectrum-separating the light, first photo-detecting means having a plurality of photoelectric conversion elements for detecting the light for plural wavelength components, and second photo-detecting means for detecting a selected wavelength component included in the light on the basis of a detection result of the first photo-detecting means.

Abstract: An ultrasonic diagnosis apparatus and method wherein both imaging of a contrast effect and imaging of a tissue appearance before and after inflow of a contrast medium can be realized on condition that low-power transmission and a high frame rate are maintained. The ultrasonic diagnostic apparatus includes a transmission/reception unit for transmitting subject ultrasonic waves with a band substantially centered at a fundamental frequency and generating a received signal based on an ultrasonic echo from the subject, a harmonic unit for extracting a signal of a harmonic component of the fundamental frequency included in the received signal and extracting a signal of the fundamental component with the band substantially centered the fundamental frequency included in the received signal, and a display unit for generating a display image based on the extracted harmonic and fundamental components.

Abstract: Spatial derivatives are computed. In one method, gradients are determined from data in an acoustic domain rather than a Cartesian or display coordinate domain. The gradients determined from data in the acoustic domain are then transformed to the Cartesian coordinate or display screen domain. For example, a matrix function representing the spatial relationship between the acoustic domain and the Cartesian coordinate domain transforms the coordinates. As a result, spatial gradients in the Cartesian system are provided where acoustic domain data is being processed. In another method for volume rendering or three-dimensional imaging, a gradient is calculated from data in the display or screen domain. Data from a reconstructed 3D Cartesian coordinate grid or data in an acoustic domain is resampled to ray lines. The ray lines correspond to the display domain as compared to an arbitrary Cartesian coordinate format. The gradients are calculated from the resampled data in the screen domain.

Abstract: A medical device for creating images of tissue within a body includes a disposable liquid-confining sheath supporting an elongate flexible drive shaft which carries an imaging device such as a ultrasound transducer. The device may include a trocar adapted to receive the sheath, the trocar permitting the device to be inserted into the body where no natural passageway exists, the trocar having a side-facing region adapted to maintain registry with the imaging device while the imaging device rotates. In another embodiment, the drive shaft includes an outer coil that is configured such that when the drive shaft is driven in the direction tending to decrease the diameter of the outer coil, the outer surface of the outer coil pressurizes liquid distally of the outer surface. The device optionally includes an inflatable balloon.

Abstract: The present invention relates to a method and apparatus providing tissue harmonic imaging using an ultrasound machine. Coded pulses and the phase inverted version of the said coded pulses with time bandwidth greater than 1 are transmitted into the tissue. Backscattered echoes are received and filtered before or after coherent summation. Decoding/compressing of the received echoes of the coded pulses is implemented naturally through the propagation of the specially designed ultrawide band (>80%) waveforms inside tissue and pulse inversion. Costly decoding/compression filter are not necessary.