Patents Examined by Fred Reyolds
  • Macrocyclic kinase inhibitors and uses thereof
    Patent number: 8975232
    Abstract: The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, RE, RF, RG, RH, RI, f, g, h, n, and m are as defined herein. The present invention further provides methods of synthesizing these macrocyclic compounds, and methods of their use and treatment. Certain aspects of the present invention relate to modulation of kinase activity, and in the treatment of kinase-associated diseases or disorders.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: March 10, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Ralph E. Kleiner