Patents Examined by Galina M Yakovleva
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Patent number: 11971419Abstract: Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Still further provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.Type: GrantFiled: April 14, 2021Date of Patent: April 30, 2024Assignee: ENZO LIFE SCIENCES, INC.Inventors: Michael C. Mullenix, Robert Elliot Zipkin, Jeffrey Kroll Adams, Wayne Forrest Patton, James J. Donegan
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Patent number: 11965851Abstract: Methods of using grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are disclosed. Said grid comprising a coating modified with one or more capture agents and a deactivating agent.Type: GrantFiled: October 21, 2020Date of Patent: April 23, 2024Assignee: Purdue Research FoundationInventors: David H. Thompson, Christopher Benjamin, Kyle Wright, Scott C. Bolton, Seok-Hee Hyun
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Patent number: 11926679Abstract: A modified peptide or a modified polypeptide has the amino acid sequence of Thr-Val-Asp-Ser-Cys-Leu-Thr (SEQ ID NO: 1) and adhesiveness to a norbornene-based polymer. A ratio of the total number of amino acids constituting the modified peptide or the modified polypeptide to the number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 contained in the modified peptide or the modified polypeptide is 7 or more and 80 or less. The number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 is 1.Type: GrantFiled: September 22, 2022Date of Patent: March 12, 2024Assignee: ZEON CORPORATIONInventor: Naoya Ichimura
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Patent number: 11913965Abstract: Methods are disclosed for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,500. The method comprises the use of a first antibody that binds to the small molecule and a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a hapten that is not the small molecule or a derivative of the small molecule wherein the hapten comprises a moiety that is structurally similar to that of the second portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.Type: GrantFiled: March 12, 2021Date of Patent: February 27, 2024Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Tie Wei
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Patent number: 11913943Abstract: System and method embodiments for analyzing a test fluid to detect prior or present infestations of bed bugs are described. In an embodiment, the method may include receiving the test fluid on a test strip within the detection device. The test strip may include a reaction portion and a reagent portion containing an antibody or antigen-binding fragment that is conjugated to a colored particle. The test fluid may include bed bug antigen that reacts with the conjugated antibody. The detection device may include a first and a second optical sensor for monitoring a reaction and a background color intensity, respectively. Upon a predetermined time delay elapsing, the detection device determines whether bed bug antigen is present in the test fluid using the monitored color intensities and minimum and maximum color intensity thresholds associated with bed bugs. Then, the detection device outputs a result using a visual display.Type: GrantFiled: August 14, 2020Date of Patent: February 27, 2024Assignee: Redcoat Solutions, Inc.Inventors: William John Hall, Benedict Louis Zin, Andy Sturman, Min Wang
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Patent number: 11913942Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.Type: GrantFiled: July 8, 2020Date of Patent: February 27, 2024Assignee: IDEXX Laboratories, Inc.Inventors: Murthy V S N Yerramilli, Hongzhi Xie, Daniel Wayne Patch, Giosi Farace
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Patent number: 11892457Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.Type: GrantFiled: July 5, 2018Date of Patent: February 6, 2024Assignees: The Johns Hopkins University, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Dax Fu, Chengfeng Merriman, Hongjie Dai, Hao Wan
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Patent number: 11885797Abstract: Provided herein are immunofluorescence assays that do not use an intensely colored lipophilic dye, and that result in a significant reduction of fluorescence due to aldehyde fixation, collagen, elastin, and/or red blood cells. In certain embodiments of the present invention, a two-step treatment of the tissue is contemplated that leads to the incorporation of reduced heteropoly acids or salts thereof (e.g., phosphomolybdate species) in the tissue. This reagent binds tightly to hydrophilic regions of the tissue and effectively quenches the fluorescence in those regions. In doing so, the overall signal-to-noise ratio for the immunofluorescence assay is increased.Type: GrantFiled: April 5, 2021Date of Patent: January 30, 2024Assignee: VECTOR LABORATORIES, INC.Inventors: Timothy B. Karpishin, Pamela James, Erika Leonard
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Patent number: 11879896Abstract: A method of determining the effect of non-specific interactions in simulated in vivo conditions is presently disclosed. The method includes (a) contacting a solution comprising a biologically relevant molecular crowding agent and a target molecule with a biosensor, wherein the surface of the biosensor comprises a capture molecule that specifically binds the target molecule; (b) allowing the target molecule to bind to the capture molecule; and (c) determining an amount of the target molecule bound to capture molecule using biolayer interferometry.Type: GrantFiled: August 22, 2022Date of Patent: January 23, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Dorothy Kim, Michael Marlow
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Patent number: 11865191Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.Type: GrantFiled: May 22, 2020Date of Patent: January 9, 2024Assignees: Life Technologies Corporation, Pierce Biotechnology, Inc.Inventors: Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
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Patent number: 11857643Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.Type: GrantFiled: March 11, 2020Date of Patent: January 2, 2024Assignees: Life Technologies Corporation, Pierce Biotechnology, Inc.Inventors: Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
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Patent number: 11860174Abstract: This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.Type: GrantFiled: December 14, 2018Date of Patent: January 2, 2024Assignee: BOMI LLCInventor: Bomi Joseph
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Patent number: 11860156Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.Type: GrantFiled: May 26, 2020Date of Patent: January 2, 2024Assignee: Genentech, Inc.Inventors: Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
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Patent number: 11834489Abstract: Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer (“smFRET”) imaging, as well as compounds useful in such methods.Type: GrantFiled: August 31, 2018Date of Patent: December 5, 2023Assignees: CORNELL UNIVERSITY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Scott C. Blanchard, Gabriel Glenn Gregorio, Brian Kobilka
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Patent number: 11821896Abstract: An object of the present invention is to provide a kit and a method which are capable of measuring a measurement target substance in a biological sample with high precision in a measurement range from a low concentration range to a high concentration range. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, including a labeled particle having a first binding substance capable of binding to a measurement target substance in a biological sample, and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.Type: GrantFiled: September 27, 2019Date of Patent: November 21, 2023Assignee: FUJIFILM CorporationInventors: Hiroyuki Chiku, Kousuke Watanabe, Kazuhei Kaneko, Kazuhiro Hamada, Kouitsu Sasaki, Tomoaki Yoshioka, Naoyuki Hanaki
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Patent number: 11808768Abstract: Compounds of general formula I wherein Fc and Fc? may be the same or different and are substituted ferrocenyl moieties having at least one ring substituent selected from sulfur-containing groups, phosphorus-containing groups, iodo, chloro, silyl, fluoroalkyl groups containing two or more fluorine atoms, heteroaryl, substituted phenyl, and cyano, wherein if present as sole substituent the cyano group is located on the proximal cyclopentadienyl ring; X is a spacer, Y is a spacer, Z is a spacer; and R is a linker group. Compound I may be used to make labelled substrates, functionalised compounds for making labelled substrates and may be used as labels in an electrochemical assay.Type: GrantFiled: November 16, 2020Date of Patent: November 7, 2023Assignee: Binx Health LimitedInventors: Barrie Marsh, Christopher Frost, David Pearce
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Patent number: 11802867Abstract: A measurement method and a measurement reagent for cardiac troponin which enable accurate measurement of the amount of cardiac troponin contained in a sample irrespective of the type of the sample and the presence or absence of other components are disclosed. The measurement method for cardiac troponin, wherein cardiac troponin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of cardiac troponin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.Type: GrantFiled: September 12, 2017Date of Patent: October 31, 2023Assignee: FUJIREBIO INC.Inventors: Mizuho Sakaki, Yoshiyuki Kitamura, Shintaro Yagi, Katsumi Aoyagi
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Patent number: 11802877Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: GrantFiled: May 26, 2020Date of Patent: October 31, 2023Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
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Patent number: 11795239Abstract: The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for anti-body-based methods, such as a lateral flow immunoassay and other point of care devices.Type: GrantFiled: October 15, 2018Date of Patent: October 24, 2023Assignee: OraSure Technologies, Inc.Inventors: Giffin Daughtridge, Keith Kardos
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Patent number: 11796535Abstract: Disclosed herein are compositions comprising beads with unique analog code identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.Type: GrantFiled: November 21, 2016Date of Patent: October 24, 2023Assignee: Plexbio Co., Ltd.Inventors: Dean Tsao, Chin-Shiou Huang, Yao-Kuang Chung