Patents Examined by Gary L. Geist
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Patent number: 5484584Abstract: The present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of radiodiagnostic agents in 1 .mu.m capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 .mu.m capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes microcapsules surface modified with hydroxyl groups.Type: GrantFiled: July 17, 1992Date of Patent: January 16, 1996Assignee: Board of Regents, The University of Texas SystemInventors: Sidney Wallace, David Yang, Michael Wallace, Chun Li, Li-Ren Kuang
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Patent number: 5480631Abstract: Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D2 receptor in the mammalian brain. These compounds have a specific combination of lipophilicity and dopamine D2 receptor affinity required to attain a required image contrast. The iodinated benzamides identified by the above discovery can be made by reacting a trialkyltin substituted benzamide with an acid in the presence of radioactive iodine which, in turn, is generated by in situ oxidation of an appropriate iodide nuclide salt.Type: GrantFiled: May 28, 1992Date of Patent: January 2, 1996Assignee: Vanderbilt UniversityInventors: Tomas De Paulis, Robert M. Kessler, Howard E. Smith, Aaron Janowski, Jeffrey A. Clanton
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Patent number: 5480581Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it contains one or more compounds of the general formula I ##STR1## in which X is fluorine, chlorine, CF.sub.3, OCF.sub.3 or OCHF.sub.2, ring A is trans-1,4-cyclohexylene or 1,4-phenylene, and R is alkyl, oxaalkyl, fluoroalkyl or alkenyl, in each case having up to 7 carbon atoms.Type: GrantFiled: April 7, 1994Date of Patent: January 2, 1996Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Herbert Plach, Ulrich Finkenzeller, Volker Reiffenrath, Eike Poetsch, Bernhard Rieger, Hiroshi Numata
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Patent number: 5478802Abstract: A gelling composition and a process for wellbore treatment comprising injecting the composition into reservoirs are disclosed wherein the composition comprise a produced brine; a water-soluble polymer such as, for example, polyacrylamide; a crosslinker such as, for example, a complexed zirconium compound; and optionally a complexing ligand such as, for example, lactic acid.Type: GrantFiled: December 29, 1992Date of Patent: December 26, 1995Assignee: Phillips Petroleum CompanyInventor: Ahmad Moradi-Araghi
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Patent number: 5476976Abstract: Fluoronitrobenzenes are prepared in an advantageous way from the corresponding chloronitrobenzenes and an alkali metal fluoride by means of a chlorine-fluorine exchange reaction with replacement of a chlorine atom by a fluorine atom, by catalyzing the reaction with a quaternaryammonium compound which comprises at least one alkoxypolyoxyalkyl radical.Type: GrantFiled: July 19, 1994Date of Patent: December 19, 1995Assignee: Hoechst AGInventors: Thomas Schach, Theodor Papenfuhs
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Patent number: 5473075Abstract: A diastereomer salt of optically active quinolinemevalonic acid of the formula ((-)I.Type: GrantFiled: September 20, 1993Date of Patent: December 5, 1995Assignee: Nissan Chemical Industries Ltd.Inventors: Yoshio Ohara, Mikio Suzuki, Yoshinobu Yanagawa, Hiroshi Iwasaki, Nobuhide Miyachi
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Patent number: 5472635Abstract: Provided is a phase plate comprising a light transmitting base, an alignment layer formed on said base, and a film formed on said alignment layer by a liquid crystalline polymer which exhibits a nematic orientation in the state of liquid crystal and assumes a glassy state at a temperature below the liquid crystal transition point of the polymer.Type: GrantFiled: March 28, 1994Date of Patent: December 5, 1995Assignees: Nippon Oil Company, Ltd., Ricoh Company, Ltd.Inventors: Shigeki Iida, Takehiro Toyooka, Hiroyuki Itoh, Yasuyuki Takiguchi, Akihiko Kanemoto, Haruo Iimura
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Process for the preparation of a stable salt-free iron chelate for use in hydrogen sulfide abatement
Patent number: 5472633Abstract: A stable, salt-free iron chelate for use in aqueous alkaline systems is prepared by contacting iron oxide with an aqueous mixture of from 30 to 45 mole percent trisodium HEDTA and from 55 to 70 mole percent EDTA, heating the mixture to dissolve the iron, and adjusting the pH to from 7 to 10 with base.Type: GrantFiled: October 6, 1992Date of Patent: December 5, 1995Assignee: The Dow Chemical CompanyInventors: Freddie Griffin, Jr., David A. Wilson, Steven H. Christiansen -
Patent number: 5472638Abstract: A corrosion inhibitor is disclosed which is produced by reacting an aqueous alkanolamine solution with an acid gas to form an amide and an alkanolamine salt, mixing aqueous alkanolamine with said amide and said alkanolamine salt in the absence of added inorganic base, and reacting the mixture at elevated temperature.Type: GrantFiled: April 28, 1994Date of Patent: December 5, 1995Assignee: Mobil Oil Corp.Inventors: Bruce D. McLaughlin, Tsoung Y. Yan
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Patent number: 5470844Abstract: The present invention is directed to a class of 3-phosphono-pyrrolidine derivatives as described by Formula I and their use as NMDA antagonists.Type: GrantFiled: November 30, 1993Date of Patent: November 28, 1995Assignee: Merrell Dow Pharmaceuticals Inc.Inventor: Jeffrey P. Whitten
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Patent number: 5468303Abstract: A rust, corrosion, and scale removing composition is provided. It comprises an additive concentrate and water. The additive concentrate preferably consists of, on a parts by weight basis, 1.5 to 5 parts glycolic acid, 0.2 to 1 parts tetrasodium salt of ethylenediaminetetraacetic acid, 2 to 6 parts citric acid, and 1 to 3 parts trisodium citrate dihydrate.Type: GrantFiled: February 25, 1994Date of Patent: November 21, 1995Assignee: ZT CorporationInventor: Glenn C. Thomas, Sr.
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Patent number: 5468717Abstract: Oxime ether derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or alkyl, Het is quinolyl, unsubstituted or substituted, and X is oxygen or sulfur, their plant-tolerated acid addition salts, metal complexes and N-oxides, and fungicides containing these compounds.Type: GrantFiled: May 4, 1994Date of Patent: November 21, 1995Assignee: BASF AktiengesellschaftInventors: Bernd Wenderoth, Siegbert Brand, Franz Schuetz, Thomas Kuekenhoehner, Franz Roehl, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5468756Abstract: Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; andX--Y--Z represents ##STR2## wherein R.sup.2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R.sup.5)H--(CH.sub.2).sub.n --R.sup.4 (wherein R.sup.4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 independently represents hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R.sup.3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryland pharmaceutically acceptable salts thereof.The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.Type: GrantFiled: May 12, 1994Date of Patent: November 21, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Takeshi Kuroda, Shigeto Kitamura, Kenji Ohmori
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Patent number: 5466807Abstract: Novel perylene compounds based on perylene-3,4,9,10-tetracarboxylic acid monoanhydride monoimides which are substituted by alkylene- or arylenesulfonic acid groups on one or both imide nitrogen atoms, or on corresponding tetracarboxylic acid diimides, or on a halogenation product thereof, have properties which render them accessible, in addition to their use as dispersing agent for pigments of the same class of compound or other categories, also for direct use as pigments and fluorescent dyestuffs as well as polymer-soluble dyestuffs.Type: GrantFiled: March 9, 1992Date of Patent: November 14, 1995Assignee: Hoechst AktiengesellschaftInventors: Erwin Dietz, Manfred Urban
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Patent number: 5464842Abstract: Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds of the formulas I to XVI are disclosed (See specification for definitions of the substituents). Specifically, the compounds are 1-azabicyclo [3.2.1]oximes, 1-azabicyclo[3.3.1]oximes, 1-aza-4-oxobicyclo[3.3.1]oximes, 1-aza-4-oxobicyclo[3.2.Type: GrantFiled: March 3, 1994Date of Patent: November 7, 1995Assignee: Warner-Lambert CompanyInventors: David J. Lauffer, Haile Tecle
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Patent number: 5464563Abstract: A bleaching composition for cellulosic materials such as paper pulp, cotton and cotton blends. The chemical system of the present invention includes a mixture of sodium hydroxide, optical brighteners and an enhanced hydrogen peroxide including a silicate-free stabilizer. In the preferred embodiment, the silicate-free stabilizer includes; magnesium acetate; phosphonic acid derivative or substituted phosphonic acids; dipicolinic acid; and the balance water. The resulting textile goods are soft, absorbent, silicate-free with a Hunter Scale whiteness of greater than about 85. Because a silicate-free stabilizer is used, low levels of extractable solids are obtained.Type: GrantFiled: August 25, 1993Date of Patent: November 7, 1995Assignee: Burlington Chemical Co., Inc.Inventors: Samuel B. Moore, James F. Leuck, Edwin T. Turner
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Patent number: 5463112Abstract: This invention concerns novel sulphoperoxyacids having the following generic formula ##STR1## wherein the R', R", and M are as defined in the specification. Bleach compositions and methods of bleaching using such novel sulphoperoxyacids are also taught.Type: GrantFiled: February 2, 1993Date of Patent: October 31, 1995Assignee: Solvay Interox LimitedInventors: John P. Sankey, William Sanderson, Graham R. Horne
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Patent number: 5463139Abstract: A composition comprising bis(fluoromethyl)ether and less than an equimolar amount of water, a process for the production of the composition comprising contacting formaldehyde with hydrogen fluoride and separating at least some of the by-product water from bis(fluoromethyl)ether, and use of the composition for the production of difluoromethane.Type: GrantFiled: June 29, 1994Date of Patent: October 31, 1995Assignee: Imperial Chemical Industries PLCInventors: Jane L. Butcher, Thomas A. Ryan, Leslie Burgess
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Patent number: 5463030Abstract: The present invention relates to a new group of compounds (e.g., N,N"-bis(2,6-dimethylcarbaniloylmethylene diethylene triamino triacetic acid, N,N"-bis(pyridoxylamine)diethylene triamino triacetic acid) which can be used as metal chelating agents and can be complexed with paramagnetic metal atoms form new complexes with improved and unexpected stability which make them extremely useful as contrast agents in magnetic resonance imaging and other types of diagnostic imaging. The chelating agents and corresponding paramagnetic metal complexes are derivatives of diethylene triamino pentaacetic acid and triethylene tetraamino hexaacetic acid.Type: GrantFiled: May 31, 1994Date of Patent: October 31, 1995Assignee: Research Foundation of the State of New YorkInventors: Gopal Subramanian, Richard F. Schneider
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Patent number: 5463060Abstract: Pergolide is produced from 8,9-dihydroelymoclavine by a one-pot process in which it is reacted successively with 1-iodopropane, with a sulfonyl halide, and with an alkali metal thiomethoxide without isolation of intermediate products.Type: GrantFiled: May 21, 1992Date of Patent: October 31, 1995Assignee: Eli Lilly and CompanyInventor: Jerry W. Misner