Abstract: An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can also be aided by making the pharmaceutical composition from amlodipine maleate particles having an average particle size of greater than 20 microns, preferably greater than 100 microns.
Type:
Grant
Filed:
August 27, 2001
Date of Patent:
July 19, 2005
Assignee:
Synthon BV
Inventors:
Jacobus M. Lemmens, Frans van Dalen, Arlette Vanderheijden
Abstract: The nanoemulsion according to the invention comprises an oily phase dispersed in an aqueous phase, having oil globules with a number-average size less than 100 nm, characterized in that it contains a ternary surfactant system comprising: a) a mixture of at least two nonionic surfactants comprising at least one ethoxylated fatty ester comprising 8 to 100 ethylene oxide units and at least one fatty acid ester of sorbitan; and b) at least one ionic surfactant chosen from alkali metal salts of cetyl phosphate and alkali metal salts of palmitoyl sarcosinate. Use in the manufacture of cosmetic, dermatological and ophthalmological compositions.