Abstract: Disclosed are: a lightening composition comprising ginseng-derived exosome-like vesicles; and a method for producing the ginseng-derived exosome-like vesicles. The ginseng-derived exosome-like vesicles may have a diameter of between 20 and 500 nm, and may be isolated from ginseng root. Because the composition comprises the ginseng-derived exosome-like vesicles as an active ingredient, said composition is effective in preventing, improving or treating skin pigmentation conditions such as liver spots, freckles, lentigo, birth marks and melanoma by effectively suppressing the production of melanin.

Abstract: A method of improving insulin resistance by using a supplement may include: administering the supplement including lysine, zinc, and vitamin C to a user; monitoring an insulin resistance level before and after the supplement is administered in a bio-sample; and determining a change in a dose of the supplement based on the insulin resistance level found in the bio-sample.

Abstract: The present invention relates to a nanoparticulate formulation comprising a transient receptor potential ankyrin-1 receptor (“TRPA1”) antagonist. Particularly, the present invention relates to a nanoparticulate formulation comprising a thienopyrimidinedione derivative as a TRPA1 antagonist and a surface stabilizer; a process for preparing such formulation; and its use in treating a respiratory disorder or pain in a subject.

Abstract: An aqueous cleansing composition for keratin fibres comprises at least one amino acid surfactant and an aqueous emulsion of divinyldimethicone/dimethicone copolymer. The amino acid surfactant 3 of the following structure wherein R1 is a saturated or unsaturated, straight or branched alkyl chain with 7 to 17 C atoms, R2 is H or a methyl, R3 is H, COO? M+, CH2COO?M or COOH, n is 0 to 2, X is COO? or SO3? and M is independent from each other H, sodium or potassium, and an aqueous emulsion of divinyldimethicone/dimethicone copolymer with an internal phase viscosity of more than 1×108 mm2/s measured at 0.01 Hz at about 25° C.

Abstract: The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads are highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.

Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.

Abstract: The present invention relates to compositions and methods for treating and/or preventing chronic- or UV-induced photodamage in the skin as well as damage to the skin caused by chronological aging and disease. Specifically, select aryl alkanones have been found to induce/produce a number of beneficial effects in the skin and skin processes by elevating the skin's defense against UV-induced damage and reversing skin photo- and/or chronological damage in the extracellular matrix (ECM) and dermal-epidermal junction (DEJ), up-regulating tissue inhibitory metalloproteases, reducing oxidative stress, inhibiting activity of matrix metalloproteases, and protecting DNA.

Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.

Abstract: An adjuvant composition contains lecithin and an organosilicon surfactant as defined herein.

Abstract: A solid dialysis A agent is provided, which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.

Abstract: A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.

Abstract: Disclosed is to a composition including difethialone, containing a configurational stereoisomer of difethialone, referred to as a hetero-stereoisomer, of formula 3-(4?-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which the carbon atoms 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations, the composition including an amount of a dextrorotatory enantiomer of the hetero-stereoisomer such that the ratio of this amount to the amount of difethialone in the composition is less than 10%; the amount of the dextrorotatory enantiomer of the hetero-stereoisomer of difethialone in the composition being different from the amount of levorotatory enantiomer of the hetero-stereoisomer of difethialone in the composition.

Abstract: The present invention relates to an aerosol device comprising a container containing: —one or more propellants, —a hair composition comprising: (i) one or more polymers containing a silicone unit bearing alkoxy-(aminomethyl)-silyl functional groups; (ii) one or more amphoteric fixing polymers and/or one or more cationic fixing polymers; the propellant(s) possibly being present in the composition or, in the container, separate from the composition.

Abstract: A method of determining a stage of CKD may comprise: measuring a creatinine level; determining a creatinine level; determining a glomerular filtration rate; and determining a stage of CKD.

Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

Abstract: The invention relates to a composition, especially a cosmetic composition, comprising at least one alkylated silicone acrylate copolymer, as well as to methods of using such compositions.

Abstract: The present invention relates to concentrated gibberellin formulations and methods of their use.

Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

Abstract: Aerosol compositions, comprising a) at least one propellant and b) at least one cosmetic preparation, including (i) at least one strengthening active substance and (ii) at least one alkoxylated carboxylic acid ester of the following formula (I), in which R1 represents a straight-chain or branched, saturated or unsaturated alkyl group having 6 to 24 carbon atoms, R2 represents hydrogen or an alkyl group having 1 to 4 carbon atoms, R3 and R4 represent, independently of each other, hydrogen or an alkyl group having 1 to 4 carbon atoms, R5 represents a straight-chain or branched, saturated or unsaturated alkyl group having 6 to 24 carbon atoms or a phenyl group, and n and m represent, independently of each other, the numbers 0 or 1 to 20, are suitable for the application of hair cosmetic agents in the form of spray mists, quickly collapsing foams.

Abstract: The invention provides a liquid agrochemical composition, preferably in the form of an emulsifiable concentrate (EC), comprising a mixture of: one or more agrochemically active ingredients (in particular comprising one or more herbicides); a C1-C6 alkyl methacrylate polymer (preferably an isobutyl methacrylate polymer); and a solvent system comprising: (c1) an alcohol solvent comprising hexylene glycol (2-methyl-2,4-pentanediol), benzyl alcohol, diacetone alcohol (2-methyl-4-oxo-pentane-2-ol), isobutanol, n-pentanol, n-hexanol, n-heptanol, n-octanol, 2-ethyl-hexanol, cyclohexanol, dipropylene glycol, diethylene glycol monomethyl ether, dipropylene glycol monomethyl ether, ethylene glycol, or a mixture of two or more of these alcohols (preferably hexylene glycol); and (c2) a heavy aromatic hydrocarbon solvent. The C1-C6 alkyl methacrylate polymer generally acts as a thickener which is suitable for the defined solvent system, and which is for increasing the viscosity of the composition.