Abstract: A kit-of-parts for visualizing by a magnetic resonance imaging (MRI) technique including a functional magnetic resonance imaging (fMRI) technique, regions of a central nervous system of a patient having an implanted active implantable medical device (AIMD) is provided. The kit-of-parts is provided and includes: the AIMD, which can be used exposed to the electromagnetic conditions for MR-images acquisition, an external processing unit for controlling the AIMD, an optical communication lead for establishing a two-way optical communication between the AIMD and an external communication unit which is controlled by the external processing unit. A patient having an implanted AIMD can be treated in a conventional MR-device for imaging, e.g., a brain region. The other elements of the kit-of-parts allow controlling the functions of the AIMD and following any effects of a stimulation on the brain region thus imaged.

Abstract: A method for calculating conduction velocity of a cardiac activation wavefront from electrophysiological (“EP”) data points generated by a mapping system during a mapping procedure for a heart is provided. The method comprises for each EP data point comprising a local activation time, and position data defining a location within the heart corresponding to the local activation time: defining a neighborhood of EP points comprising the EP data point and a selection of neighboring EP data points; representing local activation time as a function f(x,y), where x and y our coordinates within a hyperplane defined to contain the neighborhood of EP data points based on the position data for each EP data point in the neighborhood; and calculating conduction velocity at the EP data point as a norm function of a gradient for the function f(x,y).

Abstract: A heart pump assembly includes an impeller blade coupled to a rotor or a drive shaft, a cannula, a distal projection coupled to a distal end of the cannula and a blood inlet having a plurality of apertures. The plurality of apertures is radially oriented and disposed about a circumference of the cannula. The plurality of apertures includes at least a first ring of apertures which are proximal to the distal projection and a second ring of apertures which are proximal of the first ring of apertures. The plurality of apertures can allow the heart pump assembly to continue to function if anatomical structures or tissue become suctioned to a portion of the heart pump.

Abstract: Cardiac activity can be mapped by receiving an electrogram, transforming the electrogram into the wavelet domain (e.g., using a continuous wavelet transformation) to create a scalogram of the electrogram, computing at least one energy function of the scalogram, and computing at least one metric of the electrogram using the at least one energy function. The metrics of the electrogram can include, without limitation: a QRS activity duration for the electrogram; a near-field component duration for the electrogram; a far-field component duration for the electrogram; a number of multiple components for the electrogram; a slope of a sharpest component of the electrogram; a scalogram width; an energy ratio in the electrogram; and a cycle-length based metric of the electrogram.

Abstract: A system and method for generating a neonatal disorder nourishment program comprising a computing device, the computing device configured to obtain a neonatal indicator element, identify a neonatal bundle as a function of the neonatal indicator element, produce a neonatal profile as a function of the neonatal bundle, wherein producing further comprises obtaining a neonatal functional goal as a function of the neonatal bundle, receiving a neonatal recommendation as a function of a neonatal database, and producing the neonatal profile as a function of the neonatal functional goal and neonatal recommendation using a neonatal machine-learning model, determine an aliment as a function of the neonatal profile, and generate a nourishment program as a function of the aliment.

Abstract: Described herein are methods, devices, and systems for providing an implantable leadless pacemaker (LP) with a remote follow-up capability whereby the LP can provide diagnostic information to an external device that is incapable of programming the LP, wherein the LP includes two or more implantable electrodes used to output both pacing pulses and conductive communication pulses. Such a method can include the LP monitoring for a presence of one or more notification conditions associated with the LP and/or associated with a patient within which the LP is implanted, and the LP periodically outputting an advertisement sequence of pulses, using at least implantable electrodes of the LP, irrespective of whether the LP recognizes the presence of at least one notification condition. The method can also include the LP recognizing the presence of at least one notification condition, and based thereon, the LP also outputting a notification sequence of pulses.

Abstract: An implantable medical device system is configured to generate signals representing activity of a heart of a patient; determine, based on the signals, an intrinsic delay of the heart of the patient; determine whether the intrinsic delay is indicative of a first-degree heart block being present in the heart of the patient; determine a patient-specific timing regime for conduction system pacing based on whether the intrinsic delay is indicative of the first-degree heart block being present in the heart of the patient; and administer cardiac pacing to a native conduction system of the heart of the patient based on the timing regime.

Abstract: A medical device system and method estimate a time from a first voltage of a power source of a medical device to a second voltage of the power source. The medical device includes a sensor coupled to the power source for generating a physiological signal. The medical device system determines a current drain from the power source required for generating the physiological signal and/or processing the physiological signal for detecting events from the physiological signal. A processor of the medical device system is configured to estimate the time from the first voltage of the power source until the second voltage based on at least the determined current drain.

Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.

Abstract: Systems and methods for cardiac pacing during a procedure are disclosed and may include an external pulse generator (EPG) for connecting to a lead. A remote-control module (RCM) wirelessly connected to the EPG may include user inputs to control the EPG. A central processing unit (CPU) with a memory unit for storing code and a processor for executing the code may be included where the CPU is connected to the EPG and RCM. The code may control the EPG in response to user input from the RCM. The CPU may be disposed in the EPG or the RCM, or an interface module (IM) configured to communicate between an otherwise conventional EPG and the RCM. The executable code may perform a continuity test (CT) routine, a capture check (CC) routine, rapid pacing (RP) routine, and/or a back-up pacing (BP) routine, in response to user input from the RCM.

Abstract: The present invention discloses a flexible shaft structure insulating wear particles by perfusion, which includes a flexible transmission shaft, a proximal holder is provided at one end of the flexible transmission shaft, a distal holder is provided at the other end of the flexible transmission shaft, a constraint insulator and an outer sheath tube are provided outside the flexible transmission shaft, and the constraint insulator sequentially includes an inner constraint layer, an insulation layer and an outer constraint layer from inside to outside; a perfusion inflow annular cavity is formed between the outer constraint layer and the outer sheath tube and between the outer constraint layer and the insulation layer, respectively, and a static sealed inner cavity is formed between the inner constraint layer and the insulation layer and between the inner constraint layer and the flexible transmission shaft, respectively; the proximal holder is provided with a perfusion inlet pipeline communicated with the perf

Abstract: Methods and devices for providing noninvasive electrotherapy and electrical stimulation are described herein. In one aspect, a device for noninvasive electrotherapy includes wireless communication circuitry configured to receive pulse generation control signals wirelessly transmitted from a computing device. The device can include pulse generation circuitry configured to deliver electrical waveforms according to instructions encoded in the pulse generation control signals. The computing device can include a cellular telephone device, a portable media player, a personal digital assistant, a tablet computer, or an internet access device.

Abstract: An electrical transtympanic stimulator for auditory processing evaluation is disclosed. The stimulator comprises a processor, a digital-to-analog converter, a voltage-to-current convertor, and one or more electrodes. The digital-to-analog converter in communication with the processor and power source is configured to convert digital signals into analogue voltage signals. The voltage-to-current convertor in communication with the digital-to-analog converter via an amplifier is configured to convert the analogue voltage signals to current signals/pulses that are proportional to the analogue voltage signals. The electrodes in communication with the voltage-to-current convertor, configured to locate in the ear canal and on the skin around the skull of a patient, thereby performing the auditory processing evaluation by applying the current pulses to the ear canal and skull in different waveforms at various frequency ranges with parameters.

Abstract: Techniques are disclosed to identify if a current chamber being mapped is a target chamber that is desired to be mapped based on the relative position of the local activation time relative to QRS onset. Techniques are also disclosed whereby cardiac data can be labeled to indicate whether a beat was acquired while in the ventricle, or in the atrium.

Abstract: Systems and method for providing regulated muscle stimulation as part of an opioid detoxification therapy are disclosed. Instructions regarding regulated stimulations, visualizations, and parameters are received for stages of a therapy program. Regulated stimulation is administered at a muscle stimulation device and a visualization is display at an electronic display for the stage the user is at. If received biofeedback is within a parameter for the stage, positive visual feedback is displayed and the user is advanced to the next stage. If biofeedback received outside of the parameter, other visual feedback is displayed and further stimulation is ceased until biofeedback within the parameter is received.

Abstract: A watch having electrodes for physiological measurements is disclosed. The watch can be provided with an enclosure configured to couple to a wristband. An electrode can be disposed on the enclosure. Processing circuitry can be disposed in the enclosure and configured to use the electrode to obtain multiple types of physiological measurements.

Abstract: Systems and methods for classifying a cardiac arrhythmia are discussed. An exemplary system includes a correlator circuit to generate autocorrelation sequences using information of cardiac activity of a subject, including signal segments taken from a cardiac signal at respective elapsed time with respect to reference time. The correlator circuit can generate a correlation image using the autocorrelation sequences. The correlation image may be constructed by stacking the autocorrelation sequences according to the elapsed time of signal segments. An arrhythmia classifier circuit can classify the cardiac activity of the subject as one of arrhythmia types using the correlation image.

Abstract: Systems and methods for cardiac pacing during a procedure are disclosed and may include an external pulse generator (EPG) for connecting to a lead. A remote-control module (RCM) wirelessly connected to the EPG may include user inputs to control the EPG. A central processing unit (CPU) with a memory unit for storing code and a processor for executing the code may be included where the CPU is connected to the EPG and RCM. The code may control the EPG in response to user input from the RCM. The CPU may be disposed in the EPG or the RCM, or an interface module (IM) configured to communicate between an otherwise conventional EPG and the RCM. The executable code may perform a continuity test (CT) routine, a capture check (CC) routine, rapid pacing (RP) routine, and/or a back-up pacing (BP) routine, in response to user input from the RCM.

Abstract: Methods of enhancing homeostatic capacity in a subject are provided. Aspects of the methods include increasing the amplitude of an input resultant response of a homeostatic system component of the subject in a manner sufficient to enhance homeostatic capacity of the subject. Also provided are devices configured for use in practicing the methods. Aspects of the invention further include methods of treating a subject for a condition via enhancement of homeostatic capacity. The methods and devices described herein find use in a variety of applications.

Abstract: Systems, interfaces, and methods are described herein related to the evaluation of a patient's cardiac conduction system and evaluation of cardiac conduction system pacing therapy being delivered to the patient's cardiac conduction system. Evaluation of the patient's cardiac conduction system may utilize a plurality of breakthrough maps to determine where a cardiac conduction system block may be located. Evaluation of cardiac conduction system pacing therapy may utilize various electrical heterogeneity information monitored before and during delivery of cardiac conduction system pacing therapy.