Abstract: The present invention relates to a composition, preferably a cosmetic composition, and more preferably a skin cosmetic composition, comprising: (a) at least one particle, comprising at least one cationic polymer and at least one anionic polymer, at least one cationic polymer and at least one amphoteric polymer, at least one anionic polymer and at least one amphoteric polymer, or at least one amphoteric polymer, and at least one non-polymeric acid having two or more pKa values or salt(s) thereof or at least one non-polymeric base having two or more pKb values or salt(s) thereof; (b) at least one oil; and (c) water. The composition according to the present invention is stable, and can have a variety of cosmetic functions. For example, the composition according to the present invention can prepare a film which can have cosmetic effects such as moisturizing due to the oil(s).

Abstract: The present invention relates to interference pigments based on platelet-shaped substrates which are coated with at least four high refractive layers and to the use thereof, inter alia in paints, coatings, printings inks, plastics and in particular in cosmetic formulations. The interference pigments show a moderate chroma and can be used as effect pigments, as filler pigments and as protection agent against near infrared radiation, VIS and high energy light.

Abstract: An antimicrobial eyelid cleanser composition contains: (a) a hypohalous acid; (b) one or more surfactants having a HLB value of 5 to 18; and (c) an aqueous vehicle, the aqueous vehicle comprising: (i) one or more tonicity adjusters; (ii) one or more osmolality adjusters for adjusting an osmolality of the composition; and (iii) one or more pH adjusters for maintaining the pH of the composition at between about 4.5 to about 8.0. The composition can be dispensed in a foam, liquid, spray, mist, gel or lotion form. The composition can facilitate long term eyelid hygiene by removing excess oil, debris and desquamated skin and provide relief for inflammation of the eyes.

Abstract: The present invention relates to a topical composition comprising from 0.001 to 10% by weight a compound of formula (I), i.e. N-cyclopropyl nicotinamide, that provides improved antimicrobial effect through generation of antimicrobial peptides when applied to an external surface of the human body. A combination of compound of formula I and at least one ingredient selected from niacinamide, picolinamide and iso-nicotinamide triggers generation of AMPs in a synergistic way.

Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.

Abstract: The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1,000 mg, said dosage unit consisting of: 0.1-25 wt. % of estetrol particles containing at least 80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof; and 75-99.9 wt. % of one or more pharmaceutically acceptable ingredients; the solid dosage unit comprising at least 100 ?g of the estetrol component; and wherein the solid dosage unit can be obtained by a process comprising wet granulation of estetrol particles having a volume weighted average particle size of 2 ?m to 50 ?m. The solid dosage unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.

Abstract: The present invention discloses a composition comprising sugar alcohols or a combination of sugar alcohols and a Tetraselmis extract or either of the former together with niacinamide for treating or preventing dysfunctions of the human hair or skin or as a skin or hair care product.

Abstract: Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for inhibiting activation of PAR2 in skin by utilizing a synergistic combination of a water lily extract and vitamin B3 compound. The method involves treating hyperpigmented skin by applying a skin care composition containing an effective amount of a combination of water lily extract and vitamin B3 compound to a target portion of skin over the course of a treatment period.

Abstract: The invention relates to the cosmetic use of an association of (i) at least one polyphenol selected from the monomers and oligomers of flavonoids extracted from vines, the derivatives thereof and the mixtures thereof, and (ii) at least two essential oils selected from peppermint, geranium, lemon balm, lemongrass, rosemary and lavender, for treating and/or preventing oily skin or skin with oily tendencies and/or aesthetic skin problems associated therewith. The invention also relates to a cosmetic method for treating oily skin, and to compositions containing the association. It also relates to the association of polyphenols and the mixture of essential oils for treating acne or skin with oily tendencies.

Abstract: Provided are a method for manufacturing a mask pack for heavy metal adsorption comprising immersing a cellulose nonwoven fabric in an alkali solution by a cold pad batch method and then aging the cellulose nonwoven fabric at room temperature for 10 minutes to 50 minutes, and immersing the cellulose nonwoven fabric in a carboxymethylation solution by the cold pad batch method and then aging the cellulose nonwoven fabric at room temperature to 60° C. for 10 minutes to 3 hours, and a mask pack for heavy metal adsorption manufactured by the method.

Abstract: The present invention relates to a composition comprising adiponectin-derived peptide fragments and, more specifically, to a cosmetic composition and pharmaceutical composition for promoting hair growth comprising, as an active ingredient, one or more adiponectin-derived peptides selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 to 21. The adiponectin-derived peptides activate the cell division of dermal papilla cells and outer root sheath cells of hair follicles, promote hair growth in the hair follicles, and also increase the expression of hair growth factors in the dermal papilla cells, and thus a composition of the present invention comprising the adiponectin-derived peptides can be effectively used to promote hair growth and inhibit hair loss.

Abstract: Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR?NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells.

Abstract: The invention relates to oil-in-water emulsions containing 4-hydroxyacetophenone and anionic emulsifiers.

Abstract: An emulsifier-free sunscreen composition includes a suspension of oil phase droplets in a gellified water phase, the oil phase droplets including a UV filter system present from at least about 20% by weight of the composition and including one or more oil soluble UV sun filters, an amino acid gelling agent and optionally at least one diol all of which oil phase components can be blended at a temperature that is below 100 degrees C.

Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.

Abstract: Gancyclovir formulations that are ready-to-use, substantially particulate free, and stable upon storage are disclosed. Methods of manufacture and administration of such compositions are also provided.

Abstract: The present invention relates to a preterm human milk fortifier composition, more specifically to a preterm milk fortifier composition providing one or more specific nutrient in amounts that are missing in human milk of women who gave birth to a preterm infant. In particular the present invention relates to a fortifier composition designed for infants as a supplement to preterm human breast milk at the time the infant leaves the hospital (discharge) and after. The invention furthermore relates to the use of said preterm human milk fortifier composition.

Abstract: There is provided a spherical organic-inorganic composite particle having good biodegradability. The organic-inorganic composite particle according to the present invention includes 1 to 79% by weight of a silica component and 21 to 99% by weight of a biodegradable plastic. The organic-inorganic composite particle has an average particle diameter d1 of 0.5 to 25 ?m, a true density of 1.03 to 2.00 g/cm3, and a sphericity of 0.80 or more. A cosmetic product including the organic-inorganic composite particle having such properties has excellent texture properties.

Abstract: A method for forming a coating on a skin surface using a nanofiber sheet, the method including: (1) applying to the skin a sheet transparentizing agent containing 2 mass % or more of one or more oil agent; and (2) transferring a white nanofiber sheet mainly composed of a water-insoluble polymer to the skin after (1), where the transferred white nanofiber sheet becomes transparent and the coating is a transparent coating through which the skin is visible.

Abstract: A method of treating a material, the method comprising contacting the material with a composition comprising a hydroxy-substituted aldehyde. In preferred aspects of the invention the material is a keratinous material.