Patents Examined by Glenna M. Hendricks
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Patent number: 4683071Abstract: Mixtures of the compounds of the formulae I and II ##STR1## are metal passivators for functional fluids, such as hydraulic fluids and metal-working fluids in the form of aqueous polyglycol/polyglycol ether mixtures, glycol systems, oil-in-water and water-in-oil emulsions, as well as anti-freeze compositions based on glycol.A process for producing mixtures of the said type is also described.Type: GrantFiled: October 18, 1985Date of Patent: July 28, 1987Inventors: Franz Regenass, Peter C. Hamblin
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Patent number: 4670046Abstract: A tetrahydrophthalimide compound of the formula: ##STR1## wherein R is methyl or n-pentyl, which is useful as a post emergent herbicide for a soybean field.Type: GrantFiled: March 9, 1983Date of Patent: June 2, 1987Assignee: Sumitomo Chemical Company, LimitedInventors: Eiki Nagano, Shunichi Hashimoto, Ryo Yoshida, Hiroshi Matsumoto, Katsuzo Kamoshita
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Patent number: 4667027Abstract: A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.Type: GrantFiled: December 14, 1984Date of Patent: May 19, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Setsuo Harada, Yukimasa Nozaki, Hideo Ono
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Patent number: 4656288Abstract: Antibiotic TAN-558 produced by a microorganism of the genus Empedobacter or genus Lysobacter, its p-nitrobenzyl- or benzhydryl ester derivative, or their N-deacetylated derivatives or salts thereof possess antimicrobial activities against Gram-positive and Gram-negative bacteria, and can be used as a therapeutic agent for bacterial infections in mammals, fowls, etc.Type: GrantFiled: March 20, 1985Date of Patent: April 7, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Hideo Ono, Yukimasa Nozaki, Setsuo Harada
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Patent number: 4654354Abstract: The invention provides compounds of formula ##STR1## in which formula R.sub.1 and R.sub.2 are identical or different and denote:(1) taken separately: a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, an unsubstituted phenyl radical or a phenyl radical substituted with a halogen atom, with a C.sub.1 -C.sub.4 alkoxy radical or with a C.sub.1 -C.sub.4 alkoxy radical;(2) taken together either(a) a polymethylene linkage; or(b) a benzene ring; or(c) a cyclic linkage containing a nitrogen atom to constitute an isothiazolopyridinone derivative; m being able to have the values 0 or 1;the group A in the formula (IV) denoting the group ##STR2## where R.sub.8 corresponds to a hydrogen atom, a methyl radical, a hydroxymethyl radical or a --CH.sub.2 O--CO--Ret group. The invention also provides a process for preparing the abovementioned compounds and also drug compositions and cosmetic compositions containing them.Type: GrantFiled: September 23, 1985Date of Patent: March 31, 1987Assignee: Centre International De Recherches Dermatologiques (C.I.R.D.)Inventors: Braham Shroot, Gerard Lang, Jean Maignan, Michel Colin
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Patent number: 4654360Abstract: Disclosed are compounds of the formula ##STR1## wherein the several groups are defined herein. These compounds are useful for treating inflammation.Type: GrantFiled: June 1, 1984Date of Patent: March 31, 1987Assignee: Syntex (U.S.A.) Inc.Inventors: Robert J. Greenhouse, Joseph M. Muchowski
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Patent number: 4652577Abstract: Denatonium saccharide, which has a vile, bitter taste, is applied to protect an article against gnawing, biting, licking, and feeding by various animals.Type: GrantFiled: November 2, 1984Date of Patent: March 24, 1987Assignee: Atomergic Chemetals CorporationInventors: Gary T. Hollander, Mel Blum
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Patent number: 4650810Abstract: Compounds are disclosed of general formula (I): ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.6 and R.sub.7, which may be the same or different, each represents a hydrogen atom or an alkyl group;R.sub.2 represents a hydrogen atom or an alkyl, aryl, aralkyl, cycloalkyl or alkenyl group;or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, form a saturated monocyclic 5 to 7-membered ring which may optionally contain a further hetero function;R.sub.5 represents a hydrogen atom or an alkyl or alkenyl group;or R.sub.4 and R.sub.5 together form an aralkylidene group;Alk represents an alkylene chain containing two or three carbon atoms which may be unsubstituted or substituted by not more than two C.sub.1-3 alkyl groups; andX represents an oxygen or sulphur atom; and physiologically acceptable salts, solvates and bioprecursors thereof.Type: GrantFiled: January 26, 1983Date of Patent: March 17, 1987Assignee: Glaxo Group LimitedInventors: David E. Bays, Colin F. Webb, Michael D. Dowle
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Patent number: 4645837Abstract: In the transalkylation of tertiary amines, unexpected higher yields are achieved requiring substantially less catalyst and much shorter reaction times at lower reaction temperatures using a homogeneous catalyst in the presence of an alcohol solvent and carbon monoxide. The process may be exemplified by reacting triethylamine and tripropylamine in the presence of a homogeneous triosmiumdodecacarbonyl catalyst, ethanol, and carbon monoxide to prepare diethylpropylamine and ethyldipropylamine.Type: GrantFiled: November 5, 1984Date of Patent: February 24, 1987Assignee: SRI InternationalInventors: Richard M. Laine, Youval Shvo
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Patent number: 4644008Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.Type: GrantFiled: October 10, 1984Date of Patent: February 17, 1987Assignee: AdirInventors: Michel Vincent, Georges Remond, Michel Laubie
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Patent number: 4642313Abstract: A furyloxazolylacetic acid derivative of the formula: ##STR1## wherein R.sup.1 is alkyl of one to 6 carbon atoms, cycloalkyl of 5 to 6 carbon atoms, phenyl or a substituted phenyl (said substituted phenyl being phenyl group substituted with one or two radicals selected from alkyl of one to 2 carbon atoms, alkoxy of one to 2 carbon atoms and halogen), and R.sup.2 is hydrogen or alkyl of one to 12 carbon atoms. The compound (I) is useful as a hypolipidemic agent.Type: GrantFiled: February 10, 1983Date of Patent: February 10, 1987Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Kazuo Matsumoto, Kohki Takashima
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Patent number: 4642350Abstract: Process for preparing 2-(2'-hydroxyphenyl)-benzotriazoles of the formula ##STR1## from 2-nitro-2'-hydroxyazobenzenes of the formula ##STR2## which comprises reducing a 2-nitro-2'-hydroxyazobenzene compound in a strongly basic medium in the presence of an aromatic dihydroxy or dioxo compound as catalyst and of an alcohol having more than one carbon atom. The 2-(2'-hydroxyphenyl)-benzotriazole compounds are known stabilizers for organic materials.Type: GrantFiled: December 18, 1985Date of Patent: February 10, 1987Assignee: Ciba-Geigy CorporationInventors: Alexander Davatz, Tibor Somlo
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Patent number: 4636521Abstract: Compounds are disclosed of general formula (I) ##STR1## wherein R.sub.1 represents an alkyl, cycloalkyl, aryl or aralkyl group;R.sub.2, R.sub.3, R.sub.4, R.sub.6 and R.sub.7, which may be the same or different, each represents a hydrogen atom or a C.sub.1-3 alkyl group;R.sub.5 represents a hydrogen atom or an alkyl, cycloalkyl, alkenyl or an aralkyl group; or R.sub.4 and R.sub.5 together form an aralkylidene group or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a saturated monocyclic 5- to 7-membered ring; Alk represents an alkylene chain containing two or three carbon atoms which may be unsubstituted or substituted by not more than two C.sub.1-3 alkyl groups; and physiologically acceptable salts, solvates and bioprecursors thereof. The compounds are described as potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner using one or more pharmaceutically acceptable carriers or excipients.Type: GrantFiled: June 29, 1984Date of Patent: January 13, 1987Assignee: Glaxo Group LimitedInventors: Ian H. Coates, Keith Mills, Colin F. Webb, Michael D. Dowle, David E. Bays
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Patent number: 4634774Abstract: 3-hydroxy-5-methylisoxazole is prepared by reacting diketene in a continuous process with hydroxylamine to give a reaction mixture containing acetoacetohydroxamic acid and then acidifying this reaction mixture as quickly as possible to produce the 3-hydroxy-5-methylisoxazole.Type: GrantFiled: April 5, 1984Date of Patent: January 6, 1987Assignee: Sankyo Company LimitedInventors: Tadashi Murakami, Kazuo Tomita
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Patent number: 4632990Abstract: There are provided ergoline derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, R.sub.2 represents a hydrogen or halogen atom or a methyl group, R.sub.3 represents a hydrogen atom or a methoxy group, R.sub.4 represents a hydrocarbon group having from 1 to 4 carbon atoms; each of X and W independently represents a hydrogen atom, a methyl group, a chlorine atom or a methoxy group, and n is 0, 1 or 2. A method for their preparation is also provided. The compounds have strong antiprolactin activity.Type: GrantFiled: April 13, 1983Date of Patent: December 30, 1986Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Luigi Bernardi, Enzo Brambilla, Laura Chiodini, Enrico di Salle, Daniela Ruggieri, Osvaldo Sapini, Aldemio Temperilli
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Patent number: 4622402Abstract: A process for preparing certain thieno-fused heterocyclic compounds having H.sub.2 -receptor antagonist and antisecretory activity, which involves the reaction of a mercaptan, obtained by reduction of a thienoisothiazole amino alkyl disulfide, with a 5-substituted-2-furanylmethanol; and said thienoisothiazole amino alkyl disulfide intermediates.Type: GrantFiled: August 20, 1985Date of Patent: November 11, 1986Assignee: American Home Products CorporationInventors: Guy A. Schiehser, Donald P. Strike
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Patent number: 4619784Abstract: There are disclosed diffusion transfer color processes and products which employ novel image dye-providing materials which provide image dyes having the chromophoric system represented by the formula ##STR1## X is H, alkyl, aryl or substituted aryl; W is H or alkyl, R is H or alkyl; m and n are each integers of from 2 to 6.The image dye-providing material includes a diffusion control moiety such as a hydroquinonyl group and may be diffusible or nondiffusible as a function of the diffusion control moiety.Type: GrantFiled: October 27, 1980Date of Patent: October 28, 1986Assignee: Polaroid Corporation, Patent Dept.Inventors: Louis Locatell, Jr., Charles M. Zepp, Ronald F. Cieciuch
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Patent number: 4616030Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.Type: GrantFiled: December 6, 1984Date of Patent: October 7, 1986Assignee: ADIRInventors: Michel Vincent, Georges Remond, Michel Laubie
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Patent number: 4616031Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as thereapeutic drugs.Type: GrantFiled: October 10, 1984Date of Patent: October 7, 1986Assignee: ADIRInventors: Michel Vincent, Georges Remond, Michel Laubie
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Patent number: 4616029Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.Type: GrantFiled: October 10, 1984Date of Patent: October 7, 1986Assignee: ADIRInventors: Michel Vincent, Georges Remond, Michel Laubie