Patents Examined by Gollamudi S. Kishore
-
Patent number: 11964050Abstract: The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.Type: GrantFiled: July 23, 2018Date of Patent: April 23, 2024Assignee: PHARMOSA BIOPHARM INC.Inventors: Pei Kan, Yi Fong Lin, Ko Chieh Chen
-
Patent number: 11951167Abstract: The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, kidney, breast, urogenital, gastric, colorectal, cervical, vaginal, angiosarcoma, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors.Type: GrantFiled: February 5, 2021Date of Patent: April 9, 2024Assignee: GEORGETOWN UNIVERSITYInventors: Esther H. Chang, SangSoo Kim, Antonina Rait
-
Patent number: 11918688Abstract: In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.Type: GrantFiled: January 10, 2022Date of Patent: March 5, 2024Assignee: Pacira Pharmaceuticals, Inc.Inventors: Jonathan H. Slonin, Roy Winston, Stan Dysart
-
Patent number: 11905525Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering nucleic acids in vivo. These compositions have reduced immune activation resulting in accelerated blood clearance and/or anti-drug antibodies and they have an improved toxicity profile and therapeutic index in vivo.Type: GrantFiled: April 5, 2018Date of Patent: February 20, 2024Assignee: ModernaTX, Inc.Inventors: Luis Brito, Gilles Besin
-
Patent number: 11896713Abstract: A nanocarrier containing a combination of bioactive agents is provided. The nanocarrier allows for targeted delivery of the agents to cancer cells with minimized side effect.Type: GrantFiled: October 22, 2021Date of Patent: February 13, 2024Assignee: Rutgers, The State University of New JerseyInventors: Tamara Minko, Olga B. Garbuzenko
-
Patent number: 11890352Abstract: The present invention provides compositions and methods to treat cancer.Type: GrantFiled: February 27, 2019Date of Patent: February 6, 2024Assignee: University of Virginia Patent FoundationInventors: Kimberly A. Kelly, Siva Sai Krishna Dasa
-
Patent number: 11883533Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.Type: GrantFiled: June 15, 2015Date of Patent: January 30, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Jacob Klein, Ronit Goldberg, Jasmine Seror
-
Patent number: 11865212Abstract: Systems and methods for producing liposomes, including control liposomes and immunoliposomes targeting breast cancer are provided. Systems and methods for treating breast cancer, using targeted immunoliposomes produced according to various methods are also disclosed herein. For example, trastuzumab-conjugated immunoliposomes may be used to deliver chemotherapeutic agents to breast cancer tissues for the treatment of breast cancer. Systems and methods for actuating liposomes using ultrasound are also disclosed, such as systems and methods for actuating trastuzumab-conjugated liposomes accumulated in breast cancer tissues for the treatment of breast cancer.Type: GrantFiled: December 11, 2020Date of Patent: January 9, 2024Assignee: American University of SharjahInventors: Ghaleb Husseini, Mohammad Al-Sayah, Amal Elsadig
-
Patent number: 11857680Abstract: The present invention relates to a pharmaceutical liposomal composition comprising of about 0.8% w/w to about 1% w/w of docetaxel, about 30% w/w to about 38% w/w of Soya Phosphatidyl Choline, about 0.2% w/w to about 0.8% w/w of Sodium Cholesteryl Sulfate, about 61% w/w to about 68% w/w of Sucrose and a pH adjusting agent, wherein the pH of liposomal composition is less than 3.5 and the process for preparation thereof.Type: GrantFiled: October 19, 2020Date of Patent: January 2, 2024Assignee: SHILPA MEDICARE LIMITEDInventors: Kiran K Jadhav, Prashanth S, Shivakumar Pradeep, Sreenivasa Reddy
-
Patent number: 11850283Abstract: Compositions and method are therefore disclosed for treating asthma. In particular, disclosed a composition that contains one, two, or more cytidine diphosphate (CDP)-conjugated phospholipid precursors selected from the group consisting of CDP-choline, CDP-ethanolamine, and CDP-diacylglycerol in a pharmaceutically acceptable carrier for use in treating asthma.Type: GrantFiled: June 27, 2018Date of Patent: December 26, 2023Assignee: Ohio State Innovation FoundationInventor: Ian Christopher Davis
-
Patent number: 11839685Abstract: The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200 nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes.Type: GrantFiled: October 8, 2020Date of Patent: December 12, 2023Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., University of Jerusalem Ltd.Inventors: Yechezkel Barenholz, Rivka Cohen
-
Patent number: 11833125Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.Type: GrantFiled: October 27, 2021Date of Patent: December 5, 2023Assignee: PHARMOSA BIOPHARM INC.Inventors: Pei Kan, Yi Fong Lin, Ko Chieh Chen
-
Patent number: 11826087Abstract: Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions are disclosed.Type: GrantFiled: September 16, 2016Date of Patent: November 28, 2023Assignee: Coronado Aesthetics, LLCInventors: Todd James Harris, Alice Ann Chen Kim
-
Patent number: 11826468Abstract: A carrier for an insoluble active substance is disclosed. The carrier contains transfersome that includes an insoluble active substance in a high content and can stabilize the insoluble active substance. In addition, since the carrier has a small particle size, it is possible to promote the delivery of the insoluble active substance into a body of subject. Therefore, a cosmetic or pharmaceutical composition containing the carrier for an insoluble active substance can maximize the effect of the active substance.Type: GrantFiled: February 11, 2022Date of Patent: November 28, 2023Assignee: Amorepacific CorporationInventors: Shinbeom Kang, Byungryol Paik, Chaeyeon Song, Soonae An
-
Patent number: 11801221Abstract: The present application is related to a pharmaceutical composition a biphasic lipid vesicle comprising a lipid bilayer comprising vesicle forming lipids; an oil-in-water emulsion stabilized by one or more surfactants; one or more compounds; and one or more penetration enhancing agents. The one or more penetration enhancing agents include one or more non-ionic surfactants having a hydrophilic-lipophilic balance (HLB) of about 10 or less, alone or combination with one or more penetration enhancing agents selected from one or more of terpenes, alkaloids, salicylate derivatives, and polycationic surfactants and combinations thereof. The present application is also related to a pharmaceutical composition comprising a biphasic lipid vesicle comprising a lipid bilayer comprising vesicle forming lipids; an oil-in-water emulsion stabilized by one or more polycationic surfactants; and one or more compounds.Type: GrantFiled: June 16, 2022Date of Patent: October 31, 2023Assignee: DDS RESEARCH INC.Inventor: Marianna Foldvari
-
Patent number: 11793764Abstract: The present disclosure provides an siRNA nanocapsule and a preparation method and use thereof, relating to the technical field of biomedical engineering. The siRNA nanocapsule provided in the present disclosure includes siRNA and a shell encapsulating the siRNA and polymerized by a monomer A and a monomer B. The monomer A has a double bond at one end, and is electrostatically bound with the siRNA, and the monomer B includes molecules for improving tumor microenvironment sensitivity. The siRNA nanocapsule provided in the present disclosure is suitable for a wide range of clinical applications.Type: GrantFiled: December 4, 2020Date of Patent: October 24, 2023Assignee: HENAN UNIVERSITYInventors: Bingyang Shi, Yan Zou
-
Patent number: 11779582Abstract: A method for treatment of cancer selected from the group consisting of metastatic ovarian cancer, endometrial cancer, and breast cancer includes administering a composition comprising a compound represented by Formula 1, a pharmaceutically acceptable salt thereof to a subject in need thereof: The composition can efficiently kill cancer cells present in a spheroid form, thereby being usefully applied as novel medicament for metastatic ovarian cancer, endometrial cancer or breast cancer.Type: GrantFiled: January 8, 2018Date of Patent: October 10, 2023Assignee: LEMONEX INC.Inventors: Jae Ho Lee, Cheolhee Won
-
Patent number: 11759422Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: GrantFiled: April 1, 2020Date of Patent: September 19, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Andrew Geall, Ayush Verma
-
Patent number: 11752219Abstract: This invention relates to compositions useful for localized and sustained release of therapeutic agents, and more particularly to functionalized liposomes embedded in a polyelectrolyte multilayer. Methods of preparing the compositions, methods of treating diseases, devices, and pharmaceutical compositions comprising the compositions are also provided.Type: GrantFiled: November 2, 2021Date of Patent: September 12, 2023Assignee: NUtech VenturesInventors: Srivatsan Kidambi, Stephen L. Hayward
-
Patent number: 11737976Abstract: The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size.Type: GrantFiled: August 31, 2018Date of Patent: August 29, 2023Assignee: THERASYN SENSORS, INC.Inventor: Mary P. McCourt