Patents Examined by Héctor M Reyes
  • Optically active amino acid derivatives and processes for the preparation of the same
    Patent number: 6706916
    Abstract: In producing optically-active amino acid benzyl esters by reacting optically-active amino acids with benzyl alcohols, hydrazines are present in the reaction system, or the compounds are reacted in the absence of oxygen, or the compounds are reacted in the absence of oxygen while hydrazines are present in the reaction system. The processes are simple and give optically-active amino acid benzyl esters of high optical purity.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: March 16, 2004
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: Haruyo Sato, Takae Ohno, Shiho Iwata
  • Acetyloxymethyl esters and methods for using the same
    Patent number: 6699902
    Abstract: Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds are effective in the inhibition of histone deacetylase.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: March 2, 2004
    Assignee: Beacon Laboratories, Inc.
    Inventors: Hsuan-Yin Lan-Hargest, Norbert L. Wiech
  • L-DOPA ethyl ester salts and uses thereof
    Patent number: 6696600
    Abstract: The present invention provides non-hygroscopic, crystalline salts of levodopa ethyl ester (LDEE), wherein the salt is the octanoate salt, the myristate salt, the succinate salt, the succinate dihydrate salt, the fumarate salt or the fumarate dihydrate salt of levodopa ethyl ester. The subject invention also encompasses compositions comprising a levodopa ethyl ester salt and a carrier and processes for making these compositions. In addition, the subject invention concerns pharmaceutical compositions comprising a levodopa ethyl ester salt and a pharmaceutically acceptable carrier, as well as processes for making these pharmaceutical compositions.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: February 24, 2004
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Anton Frenkel, Ramy Lidor-Hadas
  • Process of the preparation of high-purity alkyladamantyl esters
    Patent number: 6696595
    Abstract: There is provided a method for obtaining an alkyladamantyl ester efficiently by distilling and purifying a crude alkyladamantyl ester containing impurities which decompose the alkyladamantyl ester without decomposing the alkyladamantyl ester. The crude alkyladamantyl ester such as crude 2-methyl-2-adamantyl methacrylate is distilled in the presence of a heterocyclic compound and/or a basic compound such as 3-ethyl-3-hydroxymethyloxetane or diglycidyl bisphenol A.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: February 24, 2004
    Assignee: Tokuyama Corporation
    Inventors: Hiromasa Yamamoto, Masao Yamaguchi, Yoshihiro Hirota, Takashi Kobayakawa
  • Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same
    Patent number: 6689902
    Abstract: 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high potency of sweetness, can be easily and efficiently prepared on an industrial production from such an aldehyde derivative, via a reductive alkylation reaction with aspartame. Therefore, 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde is extremely excellent as an intermediate for the production of N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: February 10, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kenichi Mori, Shigeru Kawahara, Tadashi Takemoto
  • Fluorinated crosslinker and composition
    Patent number: 6689900
    Abstract: Fluorinated multifunctional alcohols containing at least 3 primary hydroxyl groups are disclosed. Such alcohols allow for easy synthesis of multifunctional crosslinkers such as acrylates, epoxies and vinyl ethers. The multifunctional crosslinkers are used in fluorinated optical coating and waveguide compositions to increase curing speed and crosslinking density.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: February 10, 2004
    Assignees: E. I. du Pont de Nemours and Company, Telephotonics Incorporated
    Inventors: Fang Wang, Baopei Xu, Indira S. Pottebaum, Chuck C. Xu
  • Process and intermediates to prepare latanoprost
    Patent number: 6689901
    Abstract: The present invention is a novel intermediate, compound of the formula (VI) and salts thereof. In addition, the invention includes a process for the preparation of a 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1) contacting a the corresponding enone with (−)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about −50° to about 0° and (2) contacting the reaction mixture of step (1) with a boron complexing agent.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: February 10, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventor: Kevin E. Henegar
  • Process for the preparation of Michael-adducts
    Patent number: 6686498
    Abstract: The present invention relates to the field of organic synthesis and more specifically to a process for the preparation of Michael-adducts, as defined below, by reacting a &bgr;,&bgr;- or a &agr;,&bgr;-disubstituted, or a &agr;,&bgr;,&bgr;-trisubstituted, &agr;,&bgr;-unsaturated ketone (I) with a &bgr;-ketoester or a &bgr;-diketone (II) in presence of a suitable catalyst of formula M(X)n, according to scheme 1:
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: February 3, 2004
    Assignee: Firmenich SA
    Inventor: Denis Jacoby
  • Synthesis of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid, a key acid synthon of repaglinide
    Patent number: 6686497
    Abstract: The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxy-carbonyl-phenyl acetic acid. This compound is a key intermediate for the synthesis of Repaglinide, an oral hypoglycemic agent.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: February 3, 2004
    Assignee: Banbaxy Laboratories Limited
    Inventors: Mohammad Salman, J. Suresh Babu, Purna C. Ray, Sujay Biswas, Naresh Kumar
  • Process for the production of acetic acid
    Patent number: 6686500
    Abstract: A process for the production of acetic acid by reacting carbon monoxide with methanol and/or a reactive derivative thereof in a liquid reaction composition comprising an iridium carbonylation catalyst, methyl iodide, methyl acetate, water and acetic acid characterised in that there is also present in the reaction composition a monodentate phosphine oxide compound in an amount of up to and including 200 mol per gram atom of iridium.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: February 3, 2004
    Assignee: BP Chemicals Limited
    Inventor: Robert John Watt
  • Preparation of (R -2-alkyl-3-phenylpropionic acids
    Patent number: 6683206
    Abstract: Compounds of formula (I), wherein R1 and R2 are, independently of one another, H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1l-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yields by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R—CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leavaing group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and their hydrolysis to form corresponding propenic carboxylic acids and their enantioselective hydrogenation, wherein R is (a).
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: January 27, 2004
    Assignee: Speedel Pharma AG
    Inventors: Stefan Stutz, Peter Herold, Felix Spindler, Walter Weissensteiner, Thomas Sturm
  • Polyether-polyol compound
    Patent number: 6683222
    Abstract: A polyether-polyol compound represented by the compositional formula C3nH6n+2O2n+1, wherein n is an integer of 4 or more, wherein the polyether-polyol compound has a total number of 1,2-diol unit and 1,3-diol unit of [(n/2)+1] in a case where n is an even number of 4 or more, or a total number of 1,2-diol unit and 1,3-diol unit of [((n−1)/2)+1] and one hydroxyl group which is not involved in the units in a case where n is an odd number of 5 or more; a polyglycerol alkyl ether, a part of hydroxyl groups in a polyglycerol being substituted by an alkyl group, wherein the polyglycerol is the polyether polyol compound mentioned above; and an ester prepared by the process comprising reacting the polyether-polyol compound mentioned above or the polyglycerol alkyl ether mentioned above with a fatty acid.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: January 27, 2004
    Assignee: Taiyo Kagaku Co., Ltd.
    Inventors: Takeshi Nakamura, Masatsugu Yamashita
  • Production method of (R)-3 hydroxy-3-(2-phenylethyl) hexanoic acid and intermediate thereof
    Patent number: 6683207
    Abstract: The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: January 27, 2004
    Assignee: Sumika Fine Chemicals Co., Ltd.
    Inventors: Masahide Tanaka, Kozo Matsui, Tadashi Katsura, Mitsuhiro Iwasaki, Hiroshi Maeda, Nobushige Itaya
  • Alcohol alkoxylates used as low-foam, or foam inhibiting surfactants
    Patent number: 6680412
    Abstract: Alcohol alkoxylates of the formula (I) R1—O—(CH2—CHR5—O—)r(CH2—CH2—O—)n(CH2—CHR6—O—)s(CH2—CHR2—O—)mH  (I) where R1 is an at least singly branched C4-22-alkyl R2 is C3-4-alkyl R5 is C1-4-alkyl R6 is methyl or ethyl n is an average value from 1 to 50 m is an average value from 0 to 20 r is an average value from 0 to 50 s is an average value from 0 to 50, where m is at least 0.5 if R5 is methyl or ethyl or r is 0, or alcohol alkoxylates of the formula (II) R3—O—(CH2—CH2—O—)p(CH2—CHR4—O—)qH  (II) where R3 is branched or unbranched C4-22-alkyl R4 is C3-4-alkyl p is an average value of from 1 to 50 q is an average value of from 0.5 to 20 are used as low-foam or foam-suppressing surfactants.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: January 20, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Helmut Gümbel, Martin aus dem Kahmen, Norbert Wagner, Klaus Taeger
  • Process control in production of acetic acid via use of heavy phase density measurement
    Patent number: 6677480
    Abstract: A process for monitoring and controlling reactor conditions during the production of acetic acid by the catalyzed carbonylation of methanol is provided. The process of the present invention comprises measuring the density of the heavy phase of the light ends distillation column in the purification system of the carbonylation process. The density measurement is used to adjust the feed of methanol and/or to regulate the temperature in the reaction zone to optimize reactor conditions. The density measurement may also be used to adjust other parameters in the reactor system. The invention is also directed to the system for manufacturing acetic acid based on the process control procedure described.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: January 13, 2004
    Assignee: Celanese International Corporation
    Inventors: Michael E. Huckman, G. Paull Torrence, Hung-Cheun Cheung
  • Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23
    Patent number: 6673965
    Abstract: A compound of formula (I) wherein: R isopropyl; n is 0; R1 is naphthylmethyl; R2 is t-butyl; and R3 is methyl; is useful in the treatment of disorders mediated by s-CD23.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: January 6, 2004
    Assignee: SmithKline Beecham P.L.C.
    Inventors: John Gerard Ward, Andrew Faller
  • Aspirin-triggered lipid mediators
    Patent number: 6670396
    Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: December 30, 2003
    Assignee: Brigham and Women's Hospital
    Inventors: Charles N. Serhan, Clary B. Clish
  • Adamantane derivatives and processes for the preparation thereof
    Patent number: 6670499
    Abstract: Adamantane derivatives in which two (meth)acryloyloxyalkyl groups are bonded with an adamantane ring through ester groups, adamantane derivatives in which two adamantane rings are bonded through an alkylene group and two urethane bonds, which two adamantane rings each have a (meth)acryloyloxy group bonded thereto directly or through a coupling group, and adamantane derivatives each having a structure in which a group containing an adamantane ring hangs on the alkylene group of an alkylene glycol di(meth)acrylate. The compounds are useful as dental materials intermediates therefor, and as intermediates for optical materials such as lenses.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: December 30, 2003
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Shinya Nagano
  • Ester compounds, polymers, resist compositions and patterning process
    Patent number: 6670498
    Abstract: An ester compound of the following formula (1) is provided. R1 is H, methyl or CH2CO2R3, R2 is H, methyl or CO2R3, R3 is C1-C15 alkyl, R4 is branched or cyclic, tertiary C5-C20 alkyl group, Z is a divalent C1-C10 hydrocarbon group, and k is 0 or 1. A resist composition comprising as the base resin a polymer resulting from the ester compound is sensitive to high-energy radiation, has excellent sensitivity, resolution, and etching resistance, and is suited for micropatterning using electron beams or deep-UV.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: December 30, 2003
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Tsunehiro Nishi, Koji Hasegawa, Takeru Watanabe, Takeshi Kinsho, Mutsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
  • Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
    Patent number: 6670344
    Abstract: Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: December 30, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: John J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani