Patents Examined by Henry R. Jilan
  • Method for alleviating cisplatin-induced nephrotoxicity and dithiocarbamate compounds for effecting same
    Patent number: 4645661
    Abstract: A method for alleviating cisplatin compound-induced nephrotoxicity in animals comprising administering to the animal an effective amount of a polar dithiocarbamate compound. The polar dithiocarbamate compounds have the formula: ##STR1## In the above formula, R.sup.1 and R.sup.2 are hydrocarbon groups and R.sup.1, R.sup.2, or both R.sup.1 and R.sup.2 contain a polar group substituted thereon. M is a pharmaceutically acceptable cation and n is an integer of from 1 to 3.Novel polar dithiocarbamate compounds are disclosed as well.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: February 24, 1987
    Assignee: St. Jude Children's Research Hospital
    Inventor: Gregory R. Schonbaum