Patents by Examiner Henry R. Jiles
  • Patent number: 4851552
    Abstract: 13-oxabicyclo[10.3.0]pentadecane, a valuable ambergris fragrance, is prepared by reacting cyclododecanone with cyanoacetic acid in the presence of a Knoevenagel catalyst to form cyclododecenylacetonitrile, the nitrile is hydrolyzed to cyclododecenylacetic acid, and the acid is cyclized to the lactone, and the lactone is reduced to the corresponding diol which is cyclized to 13-oxabicyclo[10.3.0]pentadecane.
    Type: Grant
    Filed: January 10, 1985
    Date of Patent: July 25, 1989
    Assignee: Huels Aktiengesellschaft
    Inventor: Manfred Kaufhold
  • Patent number: 4766217
    Abstract: 5,6,-dihydro-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## are prepared by heating a 1-(3-furyl)-3,4-dihydro-isoquinoline of the formula ##STR2## in a primary or secondary amine to at least 80.degree. C. for several hours, the amine is removed, the reaction product is treated with dilute acid, and the reaction product is purified and isolated.
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: August 23, 1988
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Gerd Schnorrenberger
  • Patent number: 4760072
    Abstract: There are described new forms of nedocromil sodium, methods of producing these new forms and pharmaceutical formulations, especially pressurized inhalation aerosol formulations, containing finely divided nedocromil sodium. The formulations are indicated for the treatment of reversible obstructive conditions of the airways.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: July 26, 1988
    Assignee: Fisons, plc
    Inventors: Kenneth Brown, Andrew R. Clark, Richard Salliss
  • Patent number: 4754032
    Abstract: Compounds of formula I ##STR1## can be used as optical brighteners.
    Type: Grant
    Filed: February 26, 1986
    Date of Patent: June 28, 1988
    Assignee: Sandoz Ltd.
    Inventors: David L. Connell, John M. Farrar, Jurg Heller, Hans-Rudolf Schmid
  • Patent number: 4754033
    Abstract: A process for producing pyridine-2,3-dicarboxylic acid derivatives of the formula ##STR1## is described. The process is based on the cleavage of HNR.sub.10 R.sub.11 from 1-amino-1,2,3,4-tetrahydropyridine-2,3-dicarboxylic acid derivatives of the formula II ##STR2## to give 1,4-dihydropyridine-2,3-dicarboxylic acid derivatives of the formula III ##STR3## and subsequent oxidation of these compounds to obtain pyridine-2,3-dicarboxylic acid derivatives of the formula I. According to one variant of the process, the 1,4-dihydropyridine-2,3-dicarboxylic acid derivatives of the formula III are obtained directly, without isolation of the intermediately formed 1-amino-1,2,3,4-tetrahydropyridine-2,3-dicarboxylic acid derivatives of the formula II, by reaction of .alpha.,.beta.-unsaturated hydrazones of the formula IV ##STR4## with ethene-1,2-dicarboxylic acid derivatives of the formula V ##STR5## and subsequently oxidized to pyridine-2,3-dicarboxylic acid derivatives of the formula I. In the above formulae, R.sub.1, R.
    Type: Grant
    Filed: August 2, 1985
    Date of Patent: June 28, 1988
    Assignee: Ciba-Geigy Corporation
    Inventor: Adrian Waldner
  • Patent number: 4751227
    Abstract: 5-(6-Imidazo[1,2-a]pyridyl)pyridine derivatives represented by general formula: ##STR1## wherein X represents hydrogen atom or methyl group; Y represents cyano group, carboxamido group, hydrogen atom, amino group or a halogen atom; Z represents hydrogen atom or a lower alkyl group; W represents hydrogen atom or a lower alkyl group; R.sup.1 represents hydrogen atom, a lower alkyl group, phenyl group, a group shown by formula: --CH.sub.2 R.sup.4 in which R.sup.4 is a lower alkoxy group, or a group shown by formula: ##STR2## in which R.sup.5 and R.sup.6 are hydrogen atom or a lower alkyl group R.sup.2 represents hydrogen atom or a halogen atom; and R.sup.3 represents hydrogen atom, a lower alkyl group or a halogen atom; or a tautomer thereof; and pharmacologically acceptable salts thereof are disclosed. The 5-(6-imidazo[1,2-a]pyridyl)pyridine derivatives are effective for treating congestive heart failures.
    Type: Grant
    Filed: March 26, 1986
    Date of Patent: June 14, 1988
    Assignee: Eisai Co., Ltd.
    Inventors: Motosuke Yamanaka, Kazutoshi Miyake, Shinji Suda, Hideto Ohhara, Toshiaki Ogawa
  • Patent number: 4747868
    Abstract: The new compounds of the formula I or salts thereof ##STR1## in which R denotes a (substituted) cyclohexyl radical or a (substituted) cyclohexenyl radical; and Y denotes cyano, a (substituted) (di)(thio)carboxylic acid (ester), carboxamide or acetal radical, a keto or oxime radical or a heterocyclic radical, possess an advantageous action as plant growth-regulators and, in addition, have favorable herbicidal and fungicidal properties.
    Type: Grant
    Filed: April 17, 1986
    Date of Patent: May 31, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Roland Schmierer, Hilmar Mildenberger, Reinhard Handte, Helmut Burstell, Burkhard Sachse, Klaus Bauer, Hermann Bieringer
  • Patent number: 4748182
    Abstract: This invention relates to aromatic 2-aminoalkyl derivatives of 1,2-benzoisothiazol-3(2H)one-1,1-dioxides, processes for the preparation of same, and to their use as anxiolytic and antihypertensive agents.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: May 31, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Marcel Hibert, Maurice W. Gittos
  • Patent number: 4748244
    Abstract: The invention relates to a process for the preparation of pyridine-2,3-dicarboxylic acid derivatives of formula ##STR1## which process comprises reacting a hydrazone of formula II ##STR2## with a maleic acid derivative of formula III ##STR3## to give a 1-amino-1,4-dihydropyridine-2,3-dicarboxylic acid derivative of formula IV ##STR4## and subsequently removing R.sub.9 R.sub.10 NH. In the above formulae, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.9, R.sub.10 and X are as defined in claim 1. The pyridine-2,3-dicarboxylic acid derivatives of formula I are intermediates for the preparation of herbicidal compounds.
    Type: Grant
    Filed: May 3, 1985
    Date of Patent: May 31, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Adrian Waldner, Achim Roloff, Daniel Bellus
  • Patent number: 4748258
    Abstract: A mixture of cafestol and kahweol is obtained from coffee oil by treating coffee oil with anhydrous methanol in the presence of a basic catalyst, dissolving methyl esters which are formed by the reaction and then extracting the cafestol and kahweol from the reaction medium with aqueous methanol and then with a low-boiling chlorinated hydrocarbon. A process for the preparation of cafestol from kahweol is also disclosed.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: May 31, 1988
    Assignee: Nestec S.A.
    Inventor: Raymond Bertholet
  • Patent number: 4747867
    Abstract: Herbicidally active 1-aryl-4-cyano-5-halogenopyrazoles of the formula ##STR1## in which R is hydrogen or alkyl,Hal is halogen, andAr is substituted phenyl or represents polysubstituted pyridyl.Intermediates of the formulas ##STR2## are also disclosed.
    Type: Grant
    Filed: May 22, 1986
    Date of Patent: May 31, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Uta Jensen-Korte, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4747866
    Abstract: A pirimidinyloxyalkanamide derivative of Formula 1: ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkylthio group, a lower alkenylthio group, a lower alkynylthio group, a halogenated lower alkenylthio group, a cycloalkylthio group, an aroxyalkylthio group, a lower alkoxyl group, an amino group, a methanesulfonyl group, a trifluoromethyl group, an anilino group which may be substituted with a halogen atom or a benzylthio group which may be substituted with a halogen atom; R.sub.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a trifluoromethyl group, an amino group, a lower alkoxy group or a lower alkylthio group; R.sub.3 represents an ethyl group or an n-propyl group; and R.sub.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: May 31, 1988
    Assignee: Ube Industries, Ltd.
    Inventors: Tetsuo Takematsu, Yasutomo Takeuchi, Mitsuaki Takenaka, Seiji Takamura, Hiroshi Hase
  • Patent number: 4746671
    Abstract: Novel [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters, compositions containing the same, and methods of treating clinical conditions related with the production of thromboxane A.sub.2, prostacyclin and/or prostaglandins D.sub.2, E.sub.2 and F.sub.2.alpha..
    Type: Grant
    Filed: July 23, 1986
    Date of Patent: May 24, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eddy J. E. Freyne, Alfons H. M. Raeymaekers, Victor Sipido, Marc G. Venet
  • Patent number: 4746354
    Abstract: Herbicidally and insecticidally active 4-nitro-1-phenylpyrazoles of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl or halogenoalkyl,R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently is hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, or --(X).sub.n --R.sup.8,X is oxygen, sulphur, sulphinyl or sulphonyl,n is 0 or 1, andR.sup.8 is halogenoalkyl.
    Type: Grant
    Filed: March 4, 1986
    Date of Patent: May 24, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Uta Jensen-Korte, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Wolfgang Behrenz
  • Patent number: 4745111
    Abstract: Compounds of the formula ##STR1## where R and A have the meanings given in the description, and their use in the treatment of disorders are described.
    Type: Grant
    Filed: July 9, 1986
    Date of Patent: May 17, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Steiner, Hans-Juergen Teschendorf, Liliane Unger
  • Patent number: 4745189
    Abstract: A method of preparing N-halogenated organic heterocyclic compounds by reacting in an aqueous mixture under alkaline conditions (e.g. NaOH) and in the presence of a halogenated organic compound (e.g. methylene chloride), a N-hydrogen organic heterocyclic compound containing at least one NH group (e.g. 5,5-dimethylhydantoin) and a halogen-producing chemical (e.g. Br.sub.2).
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: May 17, 1988
    Assignee: Ethyl Corporation
    Inventors: John Y. Lee, Mark A. Templeton
  • Patent number: 4744819
    Abstract: Novel pyridinecarboxamide derivatives having the general formula (I) ##STR1## or salts thereof wherein R is hydrogen atom, alkoxy group, aralkyloxy group or a group of --(CH.sub.2).sub.n --R.sub.1 wherein n is an interger from 1 to 3 and R.sub.1 is hydrogen atom, hydroxy group, lower alkoxy group, mercapto group, lower alkylthio group, amino group, di-lower alkylamino group, C.sub.3-11 alkyl group, lower alkenyl group, lower alkynyl group, cycloalkyl group, 5- or 6-membered heterocyclic group, or aryl group which may be substituted by one or two substituents of halogen, lower alkyl or lower alkoxy;R.sub.2 is halogen atom, lower alkyl group, hydroxy group, lower alkoxy group, aryloxy group, carboxy group or lower alkoxycarbonyl group;R.sub.3 is hydrogen atom, halogen atom or lower alkyl group, which possess plant growth inhibitory activities and also anti-inflammatory activity.
    Type: Grant
    Filed: October 21, 1985
    Date of Patent: May 17, 1988
    Assignee: Daicel Chemical Industries Ltd.
    Inventors: Yoichiro Ueda, Yoshiyuki Hirako, Kazuhisa Masamoto, Yukihisa Goto, Hiroshi Yagihara, Yasuo Morishima, Hirokazu Osabe
  • Patent number: 4744815
    Abstract: Pyrazole derivatives of the formula I: ##STR1## wherein R represents a lower alkyl group or a lower alkenyl group atoms which may be substituted by halogen atom,X represents a halogen atom, a lower alkyl group, nitro group, cyano group, a lower alkylsulfonyl group or trifluoromethyl group,n is an integer of 2 to 4,Q represents hydrogen atom; an aralkyl group which may be substituted by halogen atom, nitro group, cyano group or a lower alkyl group; benzenesulfonyl group which may be substituted by a lower alkyl group or halogen atom; benzoyl group which may be substituted by a lower alkyl group or halogen atom; phenacyl group which may be substituted by a lower alkyl group or halogen atom; a lower alkyl group which may be substituted by halogen atom; a lower alkenyl group which may be substituted by halogen atom; or a lower alkynyl group,and a method for preparation of said derivatives, a selective herbicidal composition containing said derivatives as active ingredient,as well as a method for controlling weeds
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: May 17, 1988
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Masatoshi Baba, Norio Tanaka, Takasi Ikai, Tsutomu Nawamaki
  • Patent number: 4744813
    Abstract: An imidazolidine-2-one having the formula ##STR1## in which X, X', Y and Y' are the same or different and are selected from the group consisting of trifluoromethyl, chloro, bromo, fluoro, hydrogen, cyano, alkyl, thioalkyl, halothialkyl, alkoxy and sulfonylalkyl, wherein the alkyl groups have from one to four carbon atoms; andR is selected from the group consisting of hydrogen and alkyl wherein the alkyl groups have from one to four carbon atoms. The compounds are useful as herbicidal agents.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: May 17, 1988
    Assignee: Stauffer Chemical Co.
    Inventor: Eugene G. Teach
  • Patent number: 4745120
    Abstract: The present invention relates to new pyridines substituted in the 3-position, of the formula ##STR1## and to a process for their preparation. The compounds bring about specific inhibition of thromboxane synthetase and can thus be used as medicaments.
    Type: Grant
    Filed: August 21, 1985
    Date of Patent: May 17, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Wess, Wilhelm Bartmann, Gerhard Beck, Hans-Hermann Lau