Abstract: Alternative continuous downstream processes for the production of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.
Type:
Grant
Filed:
December 8, 2014
Date of Patent:
December 5, 2017
Assignee:
GE Healthcare AS
Inventors:
Torfinn Haaland, Arne Askildsen, Rita Heskestad Kalleberg, Sumihar Silalahi, Alf Martin Farbrot, Inger Dagny Saanum
Abstract: The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.
Abstract: The invention relates to a process for the production of liquid hydrocarbons by Fischer-Tropsch synthesis in which the reforming section of the plant comprises a process line comprising autothermal reforming (ATR) (5) or catalytic partial oxidation (CPO), and a separate process line comprising steam methane reforming (SMR) (8).
Abstract: A process for treating a composition comprising one or more desired (hydro)halocarbons and one or more undesired halogenated hydrocarbon containing impurities so as to reduce the concentration of at least one undesired halogenated hydrocarbon containing impurity, the process comprising contacting the composition with an adsorbent comprising a carbon molecular sieve.
Type:
Grant
Filed:
April 23, 2014
Date of Patent:
November 28, 2017
Assignee:
MEXICHEM AMANCO HOLDINGS S.A. de C.V.
Inventors:
Andrew Sharratt, John Hayes, Claire Rees
Abstract: A compound represented by formula (1): can be produced by: a step wherein a compound represented by formula (2): is reacted with a compound represented by formula (3): thereby obtaining a compound represented by formula (4): a step wherein a compound represented by formula (4) is reacted with hypohalogenous acid or a salt thereof, thereby obtaining a compound represented by formula (5): and a step wherein a compound represented by formula (5) is reduced.
Type:
Grant
Filed:
April 8, 2015
Date of Patent:
November 21, 2017
Assignee:
SUMITOMO CHEMICAL COMPANY, LIMITED
Inventors:
Teruki Takahashi, Kazuya Ueki, Yuta Nagashima
Abstract: The present invention provides an improved process for removing heat from an exothermic reaction. In particular, the present invention provides a process wherein heat can be removed from multiple reaction trains using a common coolant system.
Type:
Grant
Filed:
October 20, 2015
Date of Patent:
November 21, 2017
Assignee:
Velocys Technologies Limited
Inventors:
Ivan Phillip Greager, Steven Claude LeViness, Roger Allen Harris, Andre Peter Steynberg, Jasmeer Jaichland Ramlal, Dennis Parker, John Dolan
Abstract: A process is provided comprising contacting and reacting the compound CF3CF2CHXCl, wherein X is H or Cl, or the compound CF3CF?CXCl, wherein X is H or Cl, with hydrogen in the presence of a catalyst consisting essentially of Cu, Ru, Cu—Pd, Ni—Cu, and Ni—Pd, to obtain as a result thereof reaction product comprising hydrofluoropropenes or intermediates convertible to said hydrofluoropropenes, notably CF3CF?CH2 and CF3CH?CHF.
Abstract: Form liquid product stream that has a C13 to C20 hydrocarbon content of less than 5.0 wt % based upon a total weight of the liquid product stream via a process that includes contacting synthesis gas with a sulfurized Zeolite Socony Mobil-5 catalyst. The sulfurized Zeolite Socony Mobil-5 catalyst can include ZSM-5, cobalt, an alkali metal, sulfur, and a reduction promoter.
Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).
Type:
Grant
Filed:
January 28, 2015
Date of Patent:
November 14, 2017
Assignees:
Stella Pharma Corporation, Osaka Prefecture University Public Corporation
Abstract: A method of forming a hydrocarbon product, the method comprising a first step of enriching a carrier liquid with carbon monoxide and hydrogen and a subsequent step of bringing the enriched carrier liquid into contact with a catalyst in a first reaction zone of a reactor, wherein the catalyst catalyzes reaction of the carbon monoxide and hydrogen to form the hydrocarbon product.
Abstract: Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): [wherein X represents a chlorine atom, a bromine atom, or an iodine atom] with halogen in the presence of a heterogeneous transition metal catalyst to produce 2-(halogenomethyl)-1-methyl-3-nitrobenzene represented by formula (1): [wherein the symbol is as defined above].
Abstract: The present invention relates to the oxidative combustion of amine-containing wastewaters, especially in a process for preparing methacrolein. Methacrolein is used in chemical synthesis particularly as an intermediate for preparation of methacrylic acid, methyl methacrylate, or else of active ingredients, odorants or flavorings. More particularly, the present invention relates to an oxidative combustion of the amine-containing wastewaters with only low nitrogen oxide formation.
Type:
Grant
Filed:
July 15, 2014
Date of Patent:
November 14, 2017
Assignee:
EVONIK ROEHM GmbH
Inventors:
Steffen Krill, Torsten Balduf, Rudolf Burghardt, Gerhard Koelbl, Reed Zhao
Abstract: The invention relates to processes for oxygenate synthesis and homologation, to equipment and materials useful in such processes, and to the use of such oxygenate for producing olefin and polyolefin.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
November 7, 2017
Assignee:
ExxonMobil Chemical Patents Inc.
Inventors:
Monica D. Lotz, Paul F. Keusenkothen, Michael Salciccioli
Abstract: The present invention relates to a method for obtaining high purity (bromomethyl)cyclopropane and (bromomethyl)cyclobutane, starting respectively with cyclopropylmethanol and cyclobutylmethanol, under synthesis conditions that enable high productivity and high yield.
Type:
Grant
Filed:
December 1, 2014
Date of Patent:
November 7, 2017
Assignee:
MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE
Abstract: A process comprising reacting a benzoic acid with a glycol ether in the presence of phosphoric acid to produce a glycol ether ester product having low color, low odor, and low VOC content.
Type:
Grant
Filed:
June 18, 2015
Date of Patent:
November 7, 2017
Assignee:
DOW GLOBAL TECHNOLOGIES LLC
Inventors:
George J. Frycek, Felipe A. Donate, Edward D. Daugs, Rebecca J. Wachowicz, Jason L. Trumble
Abstract: The present invention relates to a process for the preparation of compounds or a mixture of compounds of the general formulae I.a or I.b wherein R1 is selected from C1-C12-alkyl, C3-C6-cycloalkyl, —C(?O)OR2, —PO(OR2a)2, aryl and hetaryl, R2, R2a are independently of each other selected from the group consisting of hydrogen, C1-C12-alkyl, C1-C12-alkenyl, where the last two radicals mentioned are unsubstituted, partly or completely halogenated or substituted by 1, 2, 3 or 4 radicals selected from the group consisting of C1-C6-alkoxy and CN, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, aryl and aryl-C1-C4-alkyl, where the last four radicals mentioned are unsubstituted or substituted by 1, 2, 3 or 4 radicals selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, —CN, and halogen, which comprises dimerizing olefin compound of the general formula II, in the presence of at least one N-heterocyclic carbene catalyst.
Type:
Grant
Filed:
May 19, 2015
Date of Patent:
October 24, 2017
Assignee:
BASF SE
Inventors:
Nicolas Vautravers, Joaquim H. Teles, Albrecht Berkessel, Mathias Paul, Veera R. Yatham
Abstract: The invention relates to converting non-aromatic hydrocarbon in the presence of CO2 to produce aromatic hydrocarbon. CO2 methanation using molecular hydrogen produced during the aromatization increases aromatic hydrocarbon yield. The invention also relates to equipment and materials useful in such upgrading, to processes for carrying out such upgrading, and to the use of such processes for, e.g., natural gas upgrading.
Type:
Grant
Filed:
August 18, 2016
Date of Patent:
October 24, 2017
Assignee:
ExxonMobil Chemical Patents Inc.
Inventors:
John S. Buchanan, Paul F. Keusenkothen, David W. Maher, Jaime A. Valencia
Abstract: The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain lacosamide with high chiral purity in a high yield through a simple and environmentally-friendly process and thus can be easily applied to mass production.
Type:
Grant
Filed:
October 27, 2014
Date of Patent:
October 17, 2017
Assignee:
ST PHARM CO., LTD.
Inventors:
Geun Jho Lim, Sun Ki Chang, Jae Hun Kim, Jong Moon Park
Abstract: The present disclosure provides oxidative coupling of methane (OCM) systems for small scale and world scale production of olefins. An OCM system may comprise an OCM subsystem that generates a product stream comprising C2+ compounds and non-C2+ impurities from methane and an oxidizing agent. At least one separations subsystem downstream of, and fluidically coupled to, the OCM subsystem can be used to separate the non-C2+ impurities from the C2+ compounds. A methanation subsystem downstream and fluidically coupled to the OCM subsystem can be used to react H2 with CO and/or CO2 in the non-C2+ impurities to generate methane, which can be recycled to the OCM subsystem. The OCM system can be integrated in a non-OCM system, such as a natural gas liquids system or an existing ethylene cracker.
Type:
Grant
Filed:
November 2, 2016
Date of Patent:
October 17, 2017
Assignee:
Siluria Technologies, Inc.
Inventors:
Guido Radaelli, Humera A. Rafique, Srinivas Vuddagiri, Erik C. Scher, Jarod McCormick, Joel Cizeron, Bipinkumar Patel, Satish Lakhapatri
Abstract: Disclosed is a process for the formation of a mixture of the compounds 2,3,3,3-tetrafluoropropene (1234yf) and vinylidene fluoride, comprising pyrolyzing 1,1,2-trifluoro-2-trifluoro-methyl-cyclobutane under conditions effective to produce a reaction product comprising 1234yf and vinylidene fluoride in a 1234yf:vinylidene fluoride molar ratio of from about 0.5 to about 1.2.
Type:
Grant
Filed:
November 8, 2016
Date of Patent:
October 17, 2017
Assignee:
Honeywell International Inc.
Inventors:
Rajiv Banavali, Haridasan K. Nair, Yian Zhai