Abstract: Heteroaryl pyridone and aza-pyridone amide compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Type:
Grant
Filed:
July 2, 2014
Date of Patent:
May 3, 2016
Assignee:
Genentech, Inc.
Inventors:
James John Crawford, Wendy Lee, Wendy B. Young
Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
Type:
Grant
Filed:
December 15, 2011
Date of Patent:
April 2, 2013
Assignee:
Acura Pharmaceuticals, Inc.
Inventors:
Vijai Kumar, David Dixon, Divya Tewari, Dilip B. Wadgaonkar