Abstract: Provided are systems, methods, and devices for brain stimulation and monitoring. Brain stimulation may be provided to enhance slow wave and spindle synchrony. Such stimulation may provide increased memory consolidation. Furthermore, brain stimulation modalities may provide enhanced sleep and awakening. For example, transcranial direct current stimulation of the brain stimulation may enhance sleep quality. Moreover, one or more markers characterizing unconsciousness are may be identified based on changes in measured power densities or spectra. Further still, the above described modalities of brain stimulation may be implemented in an open-loop or closed loop manner. Brain state parameters may be generated for building models of the brain based on determined synchrony patterns between slow waves and spindles. The models may be used to determine a mediation procedure for adjusting the intensity of slow wave oscillations to enhance slow wave and spindle synchrony.

Abstract: Methods, devices, and systems for treating spasticity, hypertonia or dystonia are disclosed. Treatment involves applying a source of direct current to one or more locations in a subject (animal, human, or other sentient being). Locations for application of direct current include the spinal column, peripheral nerves, and the cranium. The delivery of direct current is adjusted to change biological activity of or level of gene expression and/or protein expression of target molecule NKCC1.

Abstract: A nerve stimulator and a manufacturing method thereof. The nerve stimulator includes a glass substrate, and a plurality of metal pins provided on the substrate, wherein the metal pins form stimulation portions on one side of the substrate, and the density of the metal pins is greater than 15 Pin/mm2. The stimulation portions in the present nerve stimulator have a high density and a good stimulation effect. The processing method thereof is to cut out a high-density metal pin array first by using a metal underlayer, then the manufacturing method overcomes the deficiency in the prior art that it is rather difficult to manufacture a high density of nerve stimulation electrodes by using other substrates such as ceramics and the like.

Abstract: An electric current stimulation device includes a first electrode and a second electrode that are arranged in a body, and an output circuit that outputs an electric signal; wherein the electric signal by which the user feels no pain is output from the output circuit, and the electric signal is applied to a distal portion of extremities or near the same by the first electrode and the second electrode when arranging the body at the distal portion of the extremities of the user or near the same.

Abstract: A living body stimulator includes a low-frequency pulse generator, a high-frequency signal generator, a synthesizer for forming a synthesized waveform where a high-frequency signal of the high-frequency signal generator is superimposed on a low-frequency pulse signal of the low-frequency pulse generator, a waveform control signal circuit for controlling the synthesizer so that one cycle includes an ON period of the synthesized waveform where the high-frequency signal is superimposed on the low-frequency pulse signal and an OFF period where the high-frequency signal is not superimposed on the low-frequency pulse signal, and an output transformer for receiving the synthesized waveform. An impedance on an output side of the output transformer is set such that a voltage of the synthesized waveform gradually increases and decreases during the ON period on the output of the output transformer when pads connected to the output of the output transformer are attached to the living body.

Abstract: A method may include positioning a catheter, including at least one electrode, within an esophagus such that the electrode is proximate to at least one sympathetic ganglion. The methods may further include recruiting the sympathetic ganglion via an electrical signal, monitoring the recruitment of the sympathetic ganglion, and, based on the monitoring the recruitment of the sympathetic ganglion, adjusting the electrical signal from the at least one electrode.

Abstract: There is a present unmet need for non-invasive therapeutic methods for administration to brain cancer subjects that would provide a robust attack against their primary or metastatic brain cancer. The present disclosure describes such methods to therapeutically induce regression and/or elimination of primary and metastatic brain cancers through Transcranial Electromagnetic Treatment (TEMT). The methods involve 1) enhancement of brain meningeal lymph flow to increase immune trafficking between the brain cancer and cervical lymph nodes, 2) rebalancing of immune or non-immune signaling within the brain, particularly from the brain tumor to the lymphatic system, and/or 3) direct attack on cells within and around the brain tumor itself. Thus, the above described TEMT methods could induce and boost a specific immune or non-immune response to a given brain tumor, as well as directly attack the brain tumor, to provide an effective therapeutic intervention against both primary and metastatic brain cancers.

Abstract: An electrical muscle stimulation (EMS) suit having electrodes affixed thereto is disclosed. The EMS suit may include a vest portion comprising a left front portion, a right front portion, and a back portion, as well as a processor and memory storing pulse parameter settings. In some embodiments, the left front portion has a first pair of electrodes on a first channel, and the right front portion has a second pair of electrodes on a second channel. In some embodiments, the back portion has a third pair of electrodes on a third channel and positioned in a left half of the back portion, as well as a fourth pair of electrodes on a fourth channel and positioned in a left half of the back portion. During operation of the EMS suit, electrical impulses are delivered via the pairs of electrodes in accordance with the pulse parameter settings to elicit muscle contraction.

Abstract: Described herein are apparatuses (e.g., systems and devices) and methods of delivering nanosecond pulsed electrical fields (nsPEF). In particular, these apparatuses and methods may provide enhanced safety and robust operation over even very short (e.g., nanosecond and sub-nanosecond pulses) and high voltage pulsing; these benefits may be accomplished by multi-functional isolation of various subsystems and components of the apparatus, even including the low-voltage, control and command portions of the apparatus with extremely low capacitance, high voltage isolation.

Abstract: Disclosed herein are various spinal cord stimulation devices with thin film components, including a device having a flexible section disposed along a length of the elongate lead body of the device. Other stimulation devices have a flexible section disposed within the electrode body of the device. Further devices include both a flexible section disposed within the elongate lead body and a flexible section disposed within the electrode body of the device.

Abstract: Apparatuses, systems, and methods for more accurate remote monitoring of a user's body to stabilize the user during fall events and to thereby prevent the user from falling. In some embodiments, a wearable device comprising a power source, one or more sensors configured to monitor a user's COG (COG), at least one plurality of electrodes, a communications interface and a control device is provided. The wearable device is configured to apply electrical pulses according to defined electrical pulse stimulation protocols via the electrodes to target muscle groups of the user's body, causing those target muscle groups to contract and thereby stabilize the user's body during a fall event.

Abstract: An apparatus for creating resonant standing waves in biological tissue, in particular in the treatment of medical conditions, comprising at least one applicator for application to biological tissue and a drive unit for driving the at least one applicator simultaneously with AM modulated and FM modulated carrier signals in order to create resonant standing waves in the tissue.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system herein can include an electric field generating circuit configured to generate one or more electric fields, and control circuitry. The system can include one or more electrodes disposed on a first stimulation lead to deliver the electric fields to a site of a cancerous tumor within a patient and one or more electrodes disposed on a second stimulation lead to deliver the electric fields to the site of a cancerous tumor within a patient. The first and second stimulation leads can be configured to be implanted on or about a duodenum. The electric field generating circuit can generate electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.

Abstract: A surgical system corrects a surgical parameter based on a nomogram specific for a refractive laser surgery system to provide a nomogram-based corrected surgical parameter; stores the surgical parameter and the nomogram-based corrected surgical parameter as data for a patient or for one or both eyes of the patient; and compares the surgical parameter and nomogram-based corrected surgical parameter to generate a graphical representation of the surgical parameter, a target outcome parameter associated with the surgical parameter, or both, and the nomogram-based corrected surgical parameter, to generate a warning based on a comparison of the nomogram-based corrected surgical parameter to the surgical parameter or an absolute value, or both.

Abstract: Apparatuses, systems, and methods for more accurate remote monitoring of a user's body to stabilize the user during fall events and to thereby prevent the user from falling. In some embodiments, a wearable device comprising a power source, one or more sensors configured to monitor a user's COG (COG), at least one plurality of electrodes, a communications interface and a control device is provided. The wearable device is configured to apply electrical pulses according to defined electrical pulse stimulation protocols via the electrodes to target muscle groups of the user's body, causing those target muscle groups to contract and thereby stabilize the user's body during a fall event.

Abstract: In one example in accordance with the present disclosure, an emitter system is described. The emitter system includes an array of emitters. Each emitter emits waves towards a target surface. The emitter system also includes a control system. The control system includes a sensing system to determine whether emitters in the array are properly positioned relative to the target surface. A controller of the control system adjusts emitter sets of the array of emitters based on an output of the sensing system.

Abstract: An apparatus has a computer receiving input signals indicative of fetal heart rate (“FHR”) and maternal uterine activity in a patient. The computer determines when each of FHR, baseline FHR variability, FHR accelerations, FHR decelerations, and maternal uterine activity exhibit a plurality of pre-defined non-reassuring characteristics. The computer receives inputs indicating the presence of maternal, obstetrical, and fetal risk factors, and determines at predetermined times during labor a present level of risk to the fetus which accounts for the total of the number of parameters that each exhibit the non-reassuring characteristics at predetermined points in time during labor and the number of risk factors present. An output display depicts in a single graphical interface information respecting the parameters and risk factors over time during labor.

Abstract: A balloon type retinal stimulation device includes: a substrate unit having an insertion portion to be inserted into an eyeball; and a stimulation unit provided at one or both of one and the other surfaces of the substrate unit. The insertion portion is expandable and contractible as a fluid is injected into and discharged from an inside of the injection portion. When the insertion portion expands, one surface of the insertion portion matches a shape of the retina such that the stimulation unit is brought into close contact with the retina on which an image is formed, and the other surface of the insertion portion comes into close contact with an inner surface of the eyeball that is not a region of retina on which an image is formed, to support the insertion portion that is in contact with the region of retina on which an image is formed.

Abstract: A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient is provided, the apparatus comprising a transducer Patient for applying a signal to the renal nerve so as to produce a physiological response. Methods of treating sleep apnoea are also provided, including methods using the neuromodulation apparatus.

Abstract: Disclosed is an assembly for fitting/removing a heart pump in a sleeve secured in an opening in a ventricular wall, the assembly including a guide element with a distal end, a proximal end, and a lumen extending between, and opening at, the distal and proximal ends, the heart pump having a pump body. With this pump body including an assembly element, the assembly includes a gripping unit which can slide in the lumen, the gripping unit having at its free end an assembly part which is complementary with the assembly element, which part is configured to cooperate with the assembly element, and to join this free end to the pump body, in order to permit the gripping and displacement of the heart pump.