Abstract: The invention provides a process for the preparation of a carboxylic acid of formula (IV) (which is useful as a safener for herbicides): wherein R1 is hydrogen or chlorine, comprising the steps of: (i) subjecting a compound of formula (V) wherein: R1 is as defined above; and R2 is C1-C18 alkyl; C1-C6 alkoxyC1-C8 alkyl-; optionally substituted phenyl; or optionally substituted benzyl; to hydrolysis under acidic conditions to give a solution of a quinolinium salt; and (ii) adding base to the solution obtained in step (i) to give the free carboxylic acid (IV). The invention also provides a solid (e.g. particulate) form of one quinoline carboxylic acid compound within formula (IV) defined by R1 being chlorine; and novel intermediates useable in the above process.
Type:
Grant
Filed:
November 14, 2012
Date of Patent:
November 24, 2015
Assignee:
Syngenta Participations AG
Inventors:
Jean-Jacques Roger Gollut, Arnaud Jean Albert Gayet
Abstract: Fatty amine compositions made from a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives are disclosed. In another aspect, fatty amidoamines made by reacting a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with an aminoalkyl-substituted tertiary amine are disclosed. The fatty amines or amidoamines are advantageously sulfonated, sulfitated, oxidized, or reduced. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin.
Type:
Grant
Filed:
October 25, 2011
Date of Patent:
November 3, 2015
Assignee:
Stepan Company
Inventors:
Dave R. Allen, Marcos Alonso, Randal J. Bernhardt, Aaron Brown, Kelly Buchek, Gary Luebke, Renee Luka, Andrew D. Malec, Ronald A. Masters, Lawrence A. Munie, Dennis S. Murphy, Irene Shapiro, Patti Skelton, Brian Sook, Michael R. Terry, Laura Lee Whitlock, Michael Wiester, Patrick Shane Wolfe
Abstract: A personal cleansing composition that increases the deposition and retention of benefit agent containing polyacrylate microcapsules onto hair and/or skin. The personal cleansing composition is based on the combination of anionic charged polyacrylate microcapsules, cationic deposition polymers, detersive surfactant, and a carrier.
Type:
Grant
Filed:
April 4, 2012
Date of Patent:
October 20, 2015
Assignee:
The Procter & Gamble Company
Inventors:
Jiten Odhavji Dihora, Mark Anthony Brown
Abstract: The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.
Type:
Grant
Filed:
December 31, 2012
Date of Patent:
October 20, 2015
Assignee:
Foamix Pharmaceuticals Ltd.
Inventors:
Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov, Helena Shifrin
Abstract: Combinations suitable for agricultural use can include (I) a nematode-antagonistic biocontrol agent and (II) one or more agents selected, independently of each other, from any one of (A) to (H): (A) at least one fungicide; (B) at least one insecticide; (C) at least one synthetic nematicide; (D) bacterium of the genus Bacillus; (E) Harpin; (F) Isoflavones; (G) Plant growth regulators; and/or (H) Plant activators.
Type:
Grant
Filed:
April 13, 2012
Date of Patent:
October 6, 2015
Assignee:
Syngenta Participations AG
Inventors:
Palle Pedersen, Clifford George Watrin, Michael Oostendorp, Andre Luiz-Freitas de Oliveira
Abstract: The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
Type:
Grant
Filed:
June 4, 2012
Date of Patent:
September 29, 2015
Assignee:
BAYER INTELLECTUAL PROPERTY GMBH
Inventors:
Sebastian Hoffmann, Pierre Wasnaire, Ulrike Wachendorff-Neumann
Abstract: The present invention relates to a biodegradable polysorbitol-based osmotically active transporter (PSOAT) and gene therapy using the same as a gene carrier. The biodegradable polysorbitol-based osmotically active transporter (PSOAT) of the present invention includes a sorbitol skeleton, which imparts an osmotic pressure to the cell membrane to improve membrane permeability, thereby exhibiting remarkably improved transfection efficiency. Further, the polysorbitol-based osmotically active transporter of the present invention exhibits high DNA binding ability, effectively protects DNA from nuclease, exhibits physicochemical properties suitable for use as a gene carrier, and has very low cytotoxicity in vitro and in vivo, thereby capable of being used as a gene carrier for gene therapy.
Abstract: A nanoparticulate composition for the targeted therapeutic treatment of tumors. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both, or to the surface of the nanoparticle; (ii) an active compound selected from the group of doxorubicin and its pharmaceutically acceptable salts, especially hydrochloride; and optionally (iii) at least one complexing agent, a metal ion, a stabilizer/formulating agent, or a PEGylating agent. The present invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention.
Type:
Grant
Filed:
December 19, 2013
Date of Patent:
September 15, 2015
Assignee:
BBS Nanotechnology Ltd.
Inventors:
János Borbély, Zsuzsanna Csikós, Gáborné Koncz, Ildikó Schriffertne Denyicska
Abstract: The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer.
Type:
Grant
Filed:
December 28, 2012
Date of Patent:
September 15, 2015
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Embodiments of the invention relate to compounds and methods for controlling algal growth, for example, in bodies of water or surfaces exposed to algae. Provided are compounds having algicidal activities and methods of use of these compounds as well as formulations and compositions comprising the compound having algicidal activities.
Type:
Grant
Filed:
August 22, 2011
Date of Patent:
September 15, 2015
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors:
Roberto Kolter, Rebecca Case, Jon Clardy, Mohammad Seyedsayamdost
Abstract: Coating composition for an oilseed plant seed from which roots and shoots are capable of growing, wherein the coating composition comprises an organic carrier material and one or more biological agents that possess an activity against at least one or more pathogens of the oilseed plant.
Abstract: A topical composition and methods of using same for treating various skin disorders or conditions. In a particular aspect, these compositions comprise a storage-stable benzoyl peroxide-containing composition in suspension and an antibiotic or pharmaceutically acceptable salt or ester thereof in solution and a retinoid or a pharmaceutically acceptable salt thereof in suspension, wherein the topical composition has a final pH of about 3 to about 8. In an alternative embodiment, these compositions comprise a storage-stable mixture of a retinoid or a pharmaceutically acceptable salt thereof and either a benzoyl peroxide-containing composition or clindamycin or a pharmaceutically acceptable salt thereof.
Abstract: A dosage form for administration of two or more active pharmaceutical ingredients to a subject, comprising a first pharmaceutical composition comprising a first active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a first physical form selected from the group consisting of powder, granule, pellet, bead or mini-tablet form, and at least a second pharmaceutical composition comprising a second active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a second physical form selected from the group consisting of granule, pellet, bead, mini-tablet or tablet form, wherein the composition is characterized in that said first and second physical forms are selected to be different to minimize interactions between said first and second pharmaceutical compositions and to allow separation of said first and second pharmaceutical compositions for analysis on the basis of size difference.
Abstract: The present invention relates to microspheres comprising a core material, wherein the microsphere is perfectly spherical and has a moisture content less than 1%, and the method of manufacturing the same. The present invention is useful in the manufacture of sustained and modified release active pharmaceutical ingredient (API) microspheres, as a free flowing excipient for mini-tablets and in the manufacture of API dispersions.
Type:
Grant
Filed:
April 25, 2013
Date of Patent:
July 28, 2015
Assignee:
SPI Pharma, Inc.
Inventors:
Cecil W. Propst, Marc W. Meadows, Michael S. Todd
Abstract: Ethoxylated fatty acid mono-ester(s) of sorbitan with a fatty acid chain length from 8 to 14 and an overall degree of ethoxylation from 7 to 16 are new (though related to the polysorbates). These compounds are useful as adjuvants in agrochemical formulations, particularly combination formulations of herbicides having differing weed control effects, notably of non-selective herbicide and selective herbicide; particularly selective herbicide, particularly selective broadleaf herbicide, and graminicide; and selective graminicide and non-selective herbicide, especially a combination of a glyphosate type non-selective water soluble herbicide with a clethodim type selective (graminicide) herbicide, particularly to reduce or eliminate antagonism between differing types of herbicide. Formulations including such herbicide combinations and the adjuvant compounds are particularly useful in controlling weed including volunteer glyphosate resistant maize in subsequently sown glyphosate resistant soya.
Abstract: The invention relates to polymer particles in the form of filaments formed by block copolymers, as well as to the use thereof as rheology modifiers for aqueous or organic solutions. A first aspect of the invention relates to filamentous polymer particles having a length/diameter ratio greater than 100, said particles being formed by block copolymers synthesized by controlled radical emulsion polymerization in emulsion, performed using at least one hydrophobic monomer in the presence of a water-soluble marcoinitiator. The invention is characterized in that the filamentous particles are obtained in an aqueous medium for the synthesis of said block copolymers, performed by heating the reaction medium to a temperature of 60 to 120° C., the final block copolymer containing between 10 and 50 mol. % of the water-soluble macroinitiator and the hydrophobic monomer conversion rate being at least 50%.
Type:
Grant
Filed:
December 22, 2011
Date of Patent:
July 14, 2015
Assignees:
Arkema France, Universite Pierre et Marie Curie, Centre National De La Recherche Scientifique, Universite Claude Bernard Lyon, Ecole Superieure de Chimie Physique Electronique de Lyon
Abstract: The invention relates to the field of organic chemistry, pharmacology and medicine and concerns a method for producing a copolymer of sodium carboxymethyl cellulose and gossypol having the formula (I), as well as the use thereof in a combined treatment for patients with autistic spectrum disorders and cognitive impairment.
Type:
Grant
Filed:
October 6, 2011
Date of Patent:
July 14, 2015
Assignee:
Limited Liability Company “Nearmedic Plus”
Inventors:
Felix Ivanovich Ershov, Vladimir Georgievich Nesterenko, Abdushukur Abdukhalilovich Sarymsakov, Natalya Uryevna Alekseeva
Abstract: The present invention relates to novel herbicidally active 6-(2-aminophenyl)picoline derivatives and to processes for preparation thereof. The present invention further provides for the use thereof as a herbicide, especially as a herbicide for selective control of weed plants in useful plant crops, and as a plant growth regulator alone or in combination with safeners and/or in a mixture with other herbicides.
Type:
Grant
Filed:
December 12, 2011
Date of Patent:
July 14, 2015
Assignee:
BAYER INTELLECTUAL PROPERTY GMBH
Inventors:
Marco Brünjes, Uwe Döller, Hansjörg Dietrich, Michael Gerhard Hoffmann, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Elmar Gatzweiler, Ines Heinemann