Abstract: The invention provides a cell control product for use with a cytoenzymology assay to confirm enzymatic activity in devices employing electronic and/or optical means. The cell control product comprises a lyophilized mammalian cell which is capable of being rehydrated in water to exhibit cellular structure and cellular enzymatic activity so that said lyophilized cells can function effectively as a cytoenzymology cell control in an enzymatic analysis. The cellular structure of the cell control is capable of being authenticated by light scatter or microscopy analysis and the cellular enzymatic activity is capable of being authenticated by fluorescence analysis. The cell control exhibits a real time stability when stored at between 2 and 8.degree. C. for at least a two month period of time. Preferably the mammalian cell is an abnormal cell selected from Molt 4, CCRF-CEM and HL-60 cell lines.
Type:
Grant
Filed:
October 29, 1996
Date of Patent:
October 19, 1999
Assignee:
Coulter International Corp.
Inventors:
Ravindra S. Shukla, Harold R. Crews, Adry Galiounghi, Eileen Landrum, Frank J. Lucas
Abstract: The present invention is directed to a method and pharmaceutical formulations for the treatment of systemic sclerosis in mammals, by oral administration of collagen, including type I collagen, or biologically active peptide fragments thereof.
Type:
Grant
Filed:
July 16, 1996
Date of Patent:
October 5, 1999
Assignee:
The University of Tennessee Research Corporation
Inventors:
Laura Carbone, Andrew H. Kang, Kevin McKown, Arnold E. Postlethwaite, Jerome M. Seyer
Abstract: This invention relates to an herb composition which comprises an amount of 30 to 45% by weight of one or more herbs for invigorating of blood circulation, an amount of 55 to 70% by weight of one or more herbs for excreting toxin from human body, and an amount of 0.
Abstract: The invention relates to a method of stimulating the proliferation of natural killer cells with in vitro IL-16. A mixed lymphocyte cell population which contains natural killer cells can be nylon wool-purified, and cultured in the presence of an effective amount of IL-16 to stimulate the proliferation of natural killer cells. Effective concentrations of IL-16 which enhance the proliferation of natural killer cells range from 1 ng/ml to 1000 ng/ml. Both the full length IL-16 protein or the naturally occurring carboxy terminal-truncated form of IL-16 are suitable for stimulating the proliferation of the natural killer cells. The IL-16 induced proliferation results in at least a five-fold enrichment of natural killer cells, and the natural killer cells can be subsequently isolated from the mixed lymphocyte culture.
Abstract: This invention is a method for treating human erectile dysfunction using therapeutic amounts of human growth hormone (GH) administered systemically. Severing the parasympathetic nerves that regulate the erectile function during the course of surgery produces erectile dysfunction. Damage to these nerves by diseases such as diabetes mellitus and alcoholism and during aging may also produce erectile dysfunction. GH stimulates the regeneration of severed parasympathetic nerves that regulate the erectile function restoring potency. GH may act directly or by stimulating the production of insulin-like growth factor-I (IGF-I). The combination of GH plus an IGF (with or without one of the IGF binding proteins) may provide a better response than GH alone.
Abstract: A method of controlling weight in mammals by orally administering to the mammal an amount of a pharmaceutical composition containing Hypericum perforatum or active components thereof effective to control the weight of the mammal is described. The pharmaceutical composition also preferably further contains at least one thermogenic agent and at least one agent inhibiting lipogenesis. The at least one thermogenic agent includes one or more of N-acetyl-L-carnitine, cayenne extract, inositol hexanicotinate, niacin or salicin. The at least one agent inhibiting lipogenesis may be hydroxy citric acid. When the pharmaceutical composition includes Hypericum perforatum, at least one thermogenic agent and at least one agent inhibiting lipogenesis, the composition acts to control the weight of the mammal by simultaneously suppressing appetite, inducing thermogenesis and inhibiting lipogenesis.
Abstract: Provided is an herbal extract-based composition comprising an extract of Gynostemma pentaphyllum, an extract of Crataegus pinnatifida (hawthorn leaves or berries), and an extract of Camellia sinensis (green tea). Also provided is a process for preparing a herbal extract-based composition which comprises separately extracting each of hawthorn berries, green tea leaves, and Gynostemma pentaphyllum leaves; drying extraction eluates obtained from the extracting of each of hawthorn berries, green tea leaves, and Gynostemma pentaphyllum leaves to obtain organic residues in forming a hawthorn berry extract powder, green tea extract powder, and a Gynostemma pentaphyllum extract powder; and combining the green tea extract powder, the Gynostemma pentaphyllum extract powder, and the hawthorn berry extract powder in desired proportions to form the herbal extract-based composition which has health promoting effects including potent inhibition of free radicals.
Abstract: A purified xylanase produced by Acidothermus cellulolyticus is disclosed having a pH optimum of between about 3.6-4.2 and a molecular weight of between about 50-55 kD as determined by gel filtration. The disclosed xylanase is useful in the bleaching of pulp for the production of paper and in treating feed compositions.
Type:
Grant
Filed:
December 4, 1995
Date of Patent:
May 11, 1999
Assignee:
Genencor International, Inc.
Inventors:
Kathleen A. Clarkson, Andrew J. Morgan, Zhi C. Wang
Abstract: The invention relates to a method for promoting the healing of dermal wounds by applying a composition containing chitosan and the polysaccharide, heparin or heparan sulfate. Heparin or heparan sulfate can be immobilized to chitosan by ionic or covalent bonds, and the degree of N-acetylation of chitosan can range from 25% to 90%. The composition can include a cellulose derivative as an additional polysaccharide to increase the viscosity of the composition. The combination of chitosan and polysaccharide, when applied to a wound site, effectively stimulates and accelerates wound healing.
Abstract: This invention is directed to a method for stimulating, the proliferation of V.gamma.2V.delta.2 T cells comprising contacting V.gamma.2V.delta.2 T cells with a V.gamma.2V.delta.2 T cell proliferation stimulating amount of a compound selected from the group-consisting of a monoalkyl phosphate, a hydroxy monoalkyl phosphate, a carboxy monoalkyl phosphate, a monoalkyl pyrophosphate, an alkenyl pyrophosphate, a .gamma.-monoalkyl nucleoside triphosphate, a .gamma.-monoalkyl deoxnucleoside triphosphate, a .gamma.-alkenyl nucleoside triphosphate, and a .gamma.-alkenyl deoxynucleoside triphosphate.
Type:
Grant
Filed:
June 16, 1997
Date of Patent:
May 11, 1999
Assignee:
Albert Einstein College of Medicine of Yeshiva University
Inventors:
Barry R. Bloom, Yoshimasa Tanaka, Shigetoshi Sano
Abstract: Camomile oil having a high cis- and trans-spiroether content is produced in a process which includes steam distillation or aqueous distillation of fresh camomile or an extraction residue of camomile.
Abstract: The present invention discloses a method for treating patients having basal cell carcinoma comprising subcutaneous, intralesional or topical administration of Product R, a peptide-nucleic acid preparation.
Abstract: Process for the preparation of (-)-pimara-9(11),15-diene-19-oic acid(acanthoic acid) and pharmaceutical compositions comprising acanthoic acid useful for the treatment of diseases caused by an excessive production of interleukin-1 or tumor necrosis factor-.alpha..
Type:
Grant
Filed:
December 6, 1996
Date of Patent:
May 4, 1999
Assignee:
Korea Institute of Science and Technology
Abstract: A method for treating sexual dysfunction in a patient taking antidepressant medication is described, comprising administering an effective amount of ginkgo biloba to the patient. A method for treating sexual dysfunction in a patient taking anti-hypertensive medication is described, comprising administering an effective amount of ginkgo biloba to the patient. A method for treating sexual dysfunction in menopausal or perimenopausal patients is described, comprising administering an effective amount of ginkgo biloba to the patient. A method for treating sexual dysfunction that is not caused by a medication is described. A method for enhancing sexual response and performance is described. The invention further encompasses an antidepressant composition for the treatment of a patient in need of antidepressant therapy which comprises an amount of antidepressant sufficient to alleviate the depression and an amount of Ginkgo Biloba sufficient to alleviate any sexual dysfunction associated with the antidepressant.
Abstract: The present invention relates to a hemostatic composition comprising at least 0.1 NIH U/ml of thrombin, about 0.01 mU/ml of casein kinase II, and from 10 ng/ml to 100 ng/ml of sphingosine or a sphingosine derivative. The composition is effective in treating patients suffering from hemophilia, ulcers, or microbial infections. In addition, the composition is effective in reducing clotting time during the surgical procedure of suturing blood vessels.
Type:
Grant
Filed:
September 30, 1996
Date of Patent:
April 27, 1999
Assignee:
Korea Institute of Science Technology
Inventors:
Seung-Ho Kim, Jin Young Lee, Moon Hi Han
Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions, well suited for the therapeutic treatment of neurogenic red skin blotches and rosacea afflicting the skin, scalp and/or mucosae of a human subject, comprise a therapeutically/cosmetically effective amount of at least one TNF-alpha antagonist.
Abstract: A phytoestrogen oral supplement and ointment, and methods of preparing the supplement and ointment, are described. The oral phytoestrogen supplement is prepared by extracting pomegranate seeds with an aqueous solvent, and admixing the pomegranate seed extract with an herbal extract containing shizandra berries, Chinese asparagus root, and optionally Chinese licorice root and Chinese angelica root. The phytoestrogen ointment is prepared by pressing pomegranate seeds to obtain a pomegranate seed oil, and mixing the pomegranate seed oil with coconut milk to form the ointment. The phytoestrogen ointment can also contain an ethanolic extract of Chinese asparagus root and schizandra berries.
Abstract: A method of treating an injured or diseased aquatic animal by adding an emulsion of cajeput oil to water containing the aquatic animal is disclosed. Effective amounts of cajeput oil which promote recovery from bacterial or fungal diseases, or from wounds, abrasions, or burns, range from 0.001 ml to 1 ml of cajeput oil per day per 10 gallons of water. The cajeput oil emulsion can also contain 0.01% to 20% of an emulsifier, and up to 5% of a defoamer.
Abstract: The invention is a method of treating cancer comprising administering an effective amount of either a composition of three herbal extracts consisting essentially of 30% to 70% by weight Goldenseal, 20% to 40% by weight of Myrtle, and 5% to 20% by weight of Centaurea, or a composition of seven herbal extracts consisting essentially of 3% to 5% by weight Centaurea, 1.5% to 4% by weight Capsicum, 1.5% to 4% by weight Lobelia, 20% to 40% by weight Myrrh, 30% to 50% by weight Echinacea, 15% to 25% by weight Goldenseal, and 3% to 5% by weight Myrtle. The compositions were prepared by separately extracting each herb by mixing the herb in water, ethyl alcohol, or a mixture of water and ethyl ether, boiling and cooling the mixture, allowing the mixture to stand for about two weeks, filtering the mixture to obtain the liquid phase, and combining each of said extracts to obtain said compositions.
Type:
Grant
Filed:
January 31, 1996
Date of Patent:
March 2, 1999
Assignee:
Howard David Kass
Inventors:
Howard David Kass, Arnold I. Freeman, Albert Leyva