Abstract: A system for performing an endoscopic surgical procedure in a surgical cavity of a patient that includes a multi-lumen tube set including a dual lumen portion having a pressurized gas line and a return gas line for facilitating gas recirculation relative to the surgical cavity of the patient, and a single lumen portion having a gas supply and sensing line for delivering insufflation gas to the surgical cavity of the patient and for periodically sensing pressure within the surgical cavity of the patient, a first gas sealed single lumen access port communicating with the dual lumen portion of the tube set and a second valve sealed single lumen access port communicating with the single lumen portion of the tube set.

Abstract: A method and apparatus for delivery of cell therapies, introduced via percutaneous access to the circulation, and delivered to the site of vascular injury intervention.

Abstract: A catheter that includes a mechanism for deflecting a distal portion of a catheter may include a deflection knob including a first thread, a rod including a second thread that is coupled to the first thread, and a puller wire that is connected to the rod. The rod may additionally include a pocket to which the puller wire may be connected via a joining feature that may be secured in the pocket and attached to a proximal end of the puller wire. The joining feature may include a first ferrule joined, e.g., crimped, to the proximal end of the puller wire and a second ferrule secured, e.g., bonded, in the pocket and joined, e.g., crimped, to the first ferrule.

Abstract: A syringe assembly includes a syringe and a tamper evident cap disposed over a Luer connection of the syringe, the tamper evident cap having a main body that defines a proximal end defining an opening, a distal end opposite the proximal end along the axial direction, an outer surface, and an inner surface opposite the outer surface that defines a passage to receive a tip cap and the Luer connection, where the tamper evident cap is spaced from the tip cap. The main body further defines a frangible connection between the proximal and distal ends of the main body. The frangible connection can break under a force applied to the distal end of the tamper evident cap such that the proximal end of the tamper evident cap remains engaged with the syringe when the frangible connection breaks.

Abstract: A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of selecting through a graphical user interface a particular soft tissue sarcoma cell line associated with target tissue, retrieving, with said computing device, settings data associated with said selected soft tissue sarcoma cell line from a database of cell line data and associated settings data in a storage, and applying, with said computing device, said retrieved settings data to a cold atmospheric plasma system.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: A treatment apparatus which uses thermal or non-thermal plasma to treat urinary tract infections (UTIs) by destroying bacteria. The apparatus comprises an elongate probe that includes a coaxial cable for conveying radiofrequency (RF) electromagnetic (EM) energy and/or microwave EM energy, a probe tip connected at the distal end of the coaxial cable for receiving the RF and/or microwave EM energy, and a gas conduit for conveying gas to the probe tip. The probe tip comprises a first electrode connected to the inner conductor of the coaxial cable, and a second electrode connected to the outer conductor of the coaxial cable, and wherein the first electrode and second electrode are arranged to produce an electric field from the received RF and/or microwave EM energy across a flow path of gas received from the gas conduit to produce a thermal or a non-thermal plasma.

Abstract: Steerable catheter control handles and catheter assemblies that include pull wires and direction and magnitude controls on the handle operable such that adjustment of the direction and magnitude controls adjusts a direction and degree of catheter flex, thereby to steer the catheter as an operator directs.

Abstract: A cannula includes a tube having a proximal end, a distal end, and a tubular sidewall extending between the proximal end and the distal end. The cannula further includes an extendable member provided on a portion of the sidewall. The extendable member is configured to extend radially outward from the sidewall. The sidewall defines an aperture located between the proximal end and the distal end of the main tube.

Abstract: A delivery device for delivering an instrument into a catheter assembly may include a syringe, which may include a barrel and a plunger movable within the barrel. The plunger may include a handle and a stopper coupled to a distal end of the handle. The stopper may include a channel. The delivery device may include a guidewire disposed within the barrel and extending through the channel. In response to depression of the plunger, the guidewire may move through the channel and a first end of the guidewire may be advanced in the distal direction. A second end of the guidewire may be fixed.

Abstract: A guide wire includes a core shaft, a coil body curved from the proximal end side to the distal end side of the guide wire, and a fixing portion fixing the core shaft to the coil body. The core shaft includes a first contact part in contact with an inner surface of the coil body on an opposite side to the curving direction, and a second contact part in contact with the inner surface of the coil body in the curving direction, at a position closer to the distal end than the first contact part. The fixing portion includes a first fixing portion fixing the core shaft to the coil body at a position closer to the proximal end than the first contact part, and a second fixing portion fixing the core shaft to the coil body at a position closer to the distal end than the second contact part.

Abstract: Certain aspects relate to percutaneous sheaths for medical procedures as well as to related systems and methods. For example, a system for performing a percutaneous assisted medical procedure can include a percutaneous sheath. The percutaneous sheath can include a first conduit for providing aspiration into the kidney and a second conduit for passing a catheter into the kidney. The system can also include an aspiration catheter configured to be inserted into the kidney through the second conduit of the percutaneous sheath. A fluidics system can include an irrigation source comprising a pump and an aspiration source comprising a vacuum. The irrigation source can be connected to a fluid inlet of the percutaneous sheath that is connected to the first conduit. The aspiration source can be connected to the aspiration catheter.

Abstract: A medical device comprising an enclosure defining a cavity for containing agent, a lumen for receiving a pressurized gas, and a barrier positioned between the cavity and the lumen, the barrier including at least one opening for storing agent, wherein rotation of the barrier relative to the lumen establishes fluid communication between the at least one opening and the lumen for delivering agent from the at least one opening to the lumen.

Abstract: A grip accessory for a manual injection device comprises a housing having a generally hollow body for supporting a manual injection device therein. The housing comprises a distal portion comprising a first opening into which a manual injection device can be inserted, a proximal portion comprising a second opening through which a needle of the manual injection device is extendable, the proximal portion comprising a skin contacting surface at a proximal end of the device. An intermediate portion extends between the proximal and distal portions and guide means is provided on an interior surface of the distal portion for guiding a plunger rod of an injection device during delivery of an injection.

Abstract: Disclosed herein are apparatuses and methods that account for meal announcements in closed loop insulin delivery systems. Rather than simply increasing an insulin delivery rate in response to the meal announcement, the closed loop algorithm can be modified to increase the insulin on board tolerance during eating periods. This approach utilizes the stability of the cascaded loop in the closed loop algorithm to prevent the oscillations in glucose levels that can occur by simply increasing the basal rate.

Abstract: A system and method can provide for a remote electronic device to be used to remotely initiate delivery of a medicament bolus with a medical device, such as an insulin pump, with the medical device providing audible or tactile confirmation of the programmed bolus. The bolus amount can be calculated by or programmed or otherwise entered into the smartphone, etc., and then transmitted to the medical device. When the pump receives the transmitted bolus amount, it issues one or more indications such as audible sounds and/or vibrations in any number of desired combinations. For instance, each individual sound or vibration may correspond to an increment of the medicament. The user can therefore determine the size of the medicament bolus by the number of sounds or vibrations and can confirm or cancel delivery of the bolus.

Abstract: An injection device for injecting a composition contained in a medical container comprising: a body configured to receive the medical container in a fixed position relative to the body, spring-loaded piston rod translationally movable inside the body along a spring axis, between a proximal rest position and a distal operative position wherein the spring-loaded piston rod engages a stopper of the medical container, and a selective blocking mechanism comprising a braking member selectively tiltable relative to the piston rod between a blocking position wherein the braking member impinges on the piston rod so as to prevent any translational movement of the spring-loaded piston rod in a distal direction by a bracing effect and a releasing position wherein the braking member disengages from the piston rod so as to allow the piston rod to move towards the distal operative position under the spring force.

Abstract: The disclosure describes a reinforced catheter system, such as a wire, that includes an inner layer having an inner lumen configured to allow an object to slideably move within the inner lumen. The catheter system may include a reinforcement structure, having an outer coating, such as a polymer. The reinforcement structure may be coupled over the inner layer to thereby at least partially encapsulate the inner layer. The catheter system may include an outer surface coupled over the reinforcement structure and the inner layer to thereby encapsulate both the inner layer and the reinforcement structure. The outer coating of the reinforcement structure may be re-flowed to thereby bond the inner layer to the outer surface to thereby create a reinforced homogeneous structure.

Abstract: A method for controlling fluid delivery to a medical instrument comprises releasing, from a reservoir of a known size and having fluid at a volume and a first fluid pressure, a released fluid volume of the fluid to the medical instrument. The method also comprises measuring a vented fluid volume and determining a discharged fluid volume through the medical instrument based on the released fluid volume and the vented fluid volume.

Abstract: Systems, methods, and devices for administering, improving administration, or enabling the selective delivery of an agent to a target portion of a tissue are disclosed. An MRI device, at least high strength (e.g., at least 3 T), more preferably ultra high strength (e.g., at least 10 T) is directed at and applied to a target portion of a tissue, preferably brain tissue. A magnetic field is applied to the target portion of the tissue, selectively increasing local temperature and not impacting core temperature. The agent, preferably exosome carrying a therapeutic, is administered to the patient, and the agent is selectively delivered to the target portion of the tissue. Magnetic fields are optionally applied to the target portion before, during, or after administering the agent, or combinations thereof.