Abstract: An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the energy can be applied with a vapor media. The energy delivery probe can include a vapor delivery member configured to extend into a transition zone prostate tissue. A condensable vapor media can be delivered from the vapor delivery member into the transition zone tissue, wherein the condensable vapor media can propagate interstitially in the transition zone tissue and be confined in the transition zone tissue by boundary tissue adjacent to the transition zone tissue. Methods associated with use of the energy delivery probe are also covered.

Abstract: A system, apparatus, and method of using the same are disclosed for carrying out a transvascular procedure such as a Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure using energy to create a tract between the hepatic vein and the portal vein. The present invention provides a flexible puncturing solution to effectively perform a transvascular procedure such as a TIPS procedure while minimizing damage to the liver and surrounding soft tissues or organs.

Abstract: An end effector includes a distal clevis, an axle mounted to the distal clevis, a first jaw holder and corresponding first jaw member rotatably mounted to the axle, and a second jaw holder and corresponding second jaw member rotatably mounted to the axle. A sleeve axle has a first end, a second end, and a central passageway that extends between the first and second ends. The axle is received within the central passageway and the sleeve axle is rotatable relative to the axle.

Abstract: A portable electrocauter used especially for electrofulguration, electrodesiccation and electrocoagulation contains a source of energy and an applicator. The electrocauter is provided with the source of DC with the maximal current of 1 mA and voltage between 0.8 to 12 kV. The applicator is provided with precisely aiming finish and the patient is conductively connected with the equipment by disposable grounding electrode while the output of the discharge between the working electrode and the surface of the skin is in the range of 0.3 to 4.0 W.

Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.

Abstract: The present disclosure relates to a surgical tool for cutting and hemostasis of biological tissues. The surgical tool includes a hollow blade comprising a cutting implement residing within a hollow cavity configured to provide high-pressure steam through an apical surface. The cutting implement can operate independently or in cooperation with the provided high-pressure steam. The surgical tool of the present disclosure applies a directionally-controlled, high-pressure steam flow to a tissue region of interest. A control unit provides temperature-controlled steam at a flow-rate determined in accordance with tissue type and intended procedure.

Abstract: Various aspects of the invention relate to methods and devices for treating diseases and conditions including atherosclerosis and endocarditis using low-temperature, non-equilibrium plasmas. A device may be, for example, a catheter that carries electrodes and a dielectric material for generating a localized, non-equilibrium plasma in a bodily fluid such as blood.

Abstract: An electroporation therapy apparatus method, and system is provided. The apparatus, system, and method comprise an electroporation generator (26). The electroporation generator (26) is configured to output an asymmetric balanced waveform to a medical device, and the asymmetric balanced waveform comprises a first positive phase and a first negative phase. The first positive phase comprises a first current and a first time and the first negative phase comprises a second current and a second time. The first current is greater than the second current and the second time is greater than the first time. The asymmetric balanced waveform is configured to irreversibly electroporate a target tissue.

Abstract: Electrosurgery blades including electrosurgery blade assemblies having argon beam capability. The electrosurgery blade includes a non-conductive planar member having opposite planar sides and a sharp cutting tip and a conductive layer located on one or both of the opposing planar sides of the non-conductive layer. In embodiments of the electrosurgery blade assemblies having argon beam capability, the electrosurgery blade assembly includes a non-conductive tube member having a hollow tubular shaped opening and a slot where at least a portion of the conductive layer of the electrosurgery blade is positioned within the slot of the non-conductive tube member.

Abstract: A method, including performing an initial ablation of a tissue using an electrode in a probe distal end to apply a first power to the tissue, and measuring a change of temperature of the distal end while applying the first power. The method also includes estimating a thickness of the tissue in response to the measured change of temperature, and in response to the estimated thickness, computing at least one of a second power required and a time period for ablation, to complete ablation of the tissue. The method further includes performing a subsequent ablation of the tissue using the computed at least one of the second power and the time period for ablation.

Abstract: Apparatus and methods for deactivating pulmonary nerves extending along the main bronchi of a mammalian subject to reduce ARDS effects by advancing an ultrasound transducer into the right and subsequently left main bronchus. The ultrasound transducer emits circumferential ultrasound so as to heat a circumferential tissue volume encompassing the right and left main bronchus. The energy of <10 W acoustic for <5 sec will not be sufficient to cause tissue necrosis but sufficient to inactivate nerve conduction. This treatment can be performed without locating or focusing on individual pulmonary nerves.

Abstract: Electrosurgical apparatuses having bent tip applicators are provided. In one implementation, an electrosurgical apparatus includes an insulating outer tube having a longitudinal axis, a proximal end, and a distal end. An outer tube distal housing has its proximal end coupled to the distal end of the insulating outer tube. A distal end of the outer tube distal housing extends from the insulating outer tube at an acute angle relative to the longitudinal axis. The exemplary electrosurgical apparatus further includes an electrically conducting tube disposed within the insulating outer tube and moveable along the longitudinal axis of the insulating outer tube. An electrode is coupled to a distal end of the electrically conducting tube. The exemplary electrosurgical apparatus may include a knob coupled to the insulating outer tube to effect rotation of the outer tube distal housing in 360 degrees of rotation.

Abstract: Provided is a catheter including a shaft having a distal end and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue.

Abstract: The present invention relates to methods of removing a lesion from a patient. A method of removing a lesion from a patient includes positioning wire loops of a probe device relative to the lesion. The wire loops are simultaneously rotated and expanded to cut material from the lesion. Irrigation fluid is supplied, via the probe device, to irrigate the material cut from the lesion. The supplied irrigation fluid is aspirated, via the probe device, to facilitate removal of the material cut from the lesion.

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

Abstract: A joint surgical system includes, a treatment tool, a high-frequency output section which outputs high-frequency energy to the treatment tool, an ultrasonic output section which outputs ultrasonic energy to the treatment tool, a measurement section which measures a temperature of the liquid, and a control section which controls the high-frequency output section to stop output of the high-frequency energy and controls the ultrasonic output section to continue output of the ultrasonic energy when a measurement temperature measured by the measurement section is equal to or higher than a predetermined temperature.

Abstract: A plurality of catheter-based ablation apparatus embodiments are provided that address several areas of atrial target tissue and which feature firm and consistent ablation element to tissue contact enabling the creation of effective continuous lesions.

Abstract: Medical devices for renal nerve ablation are disclosed. An example medical device for renal nerve ablation may include a catheter shaft having a distal region. The device may include an expandable member coupled to the distal region, a flexible circuit assembly coupled to the expandable member, and a pressure sensor disposed along the expandable member and positioned adjacent to the flexible circuit assembly. The flexible circuit assembly may include one or more pairs of bipolar electrodes and a temperature sensor.

Abstract: A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue.

Abstract: An electrosurgical wand is disclosed. The electrosurgical wand includes a handle that defines a proximal end of the electrosurgical wand. The electrosurgical wand includes an elongate shaft coupled to the handle; the elongate shaft defines a suction lumen therein. The electrosurgical wand also includes an electrically insulative spacer (404) coupled to the distal end of the elongate shaft, whereby the spacer defines a suction channel (412) fluidly coupled to the suction lumen. The electrosurgical wand includes a first means for blocking defined by the spacer, an active electrode (402) coupled on the distal end of the spacer and a second means for blocking associated with the active electrode and in operational relationship to the first means for blocking. In the electrosurgical wand, the first means for blocking includes an annular trough (416) that fully encircles the suction channel of the spacer and the second means for blocking includes an annular wall (414).