Patents Examined by Jean Caraballo-Leon
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Device for sorting bio-particles using image-manipulated electric force and operating method thereof
Patent number: 11453008Abstract: A device for sorting bio-particles by image-manipulated electric force includes a first substrate, a second substrate, a fluidic channel, one or more photosensitive layers and an inlet hole. The first substrate has a first conductive electrode, and the second substrate has a second conductive electrode. The second conductive electrode is disposed opposite the first conductive electrode. The fluidic channel is disposed between the first conductive electrode and the second conductive electrode. The photosensitive layer is conformally disposed on at least one of the surfaces of the first conductive electrode and the second conductive electrode. The inlet hole is disposed in the first conductive electrode and the first substrate, where the inlet hole includes a first opening close to the fluidic channel and a second opening away from the fluidic channel, and the surface area of the first opening is greater than the surface area of the second opening.Type: GrantFiled: March 18, 2020Date of Patent: September 27, 2022Assignee: Ace Medical Technology Co., Ltd.Inventors: Tzu-Keng Chiu, Yu-Xian Zhu, Huan-Yi Tseng -
Patent number: 11446662Abstract: A system for capturing a biomolecule in a single cell includes: a two-dimensional array having single cell capture holes on one surface of a substrate, and biomolecule capture areas inside the substrate each comprising a biomolecule capture member for capturing a biomolecule extracted from individual cells respectively captured by the single cell capture holes; a flow channel for flowing a sample containing cells to be assayed, from a 1st direction parallel to the surface of the substrate; a structure on the surface of the substrate and opposed to the 1st direction on the downstream side of each of the single cell capture holes; a 1st application means applying a 1st flow, and a 1st control means; and a 2nd application means applying a 2nd flow orthogonal to the one surface of the substrate toward each biomolecule capture area from each corresponding single cell capture hole, and a 2nd control means.Type: GrantFiled: March 28, 2016Date of Patent: September 20, 2022Assignee: HITACHI, LTD.Inventors: Tomoyuki Sakai, Masataka Shirai
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Patent number: 11440009Abstract: A method may include etching a number of holes into a carrier wafer layer to form a plurality of filters in the carrier wafer layer, patterning a chamber layer over a first side of the carrier wafer layer to form chambers above each filter formed in the carrier wafer layer, forming a layer over the chamber layer, grinding a second side of the carrier wafer layer to expose the number of holes etched into the carrier wafer layer, and bonding a molded substrate to the carrier wafer layer opposite the chamber layer.Type: GrantFiled: July 15, 2016Date of Patent: September 13, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Chien-Hua Chen, Michael W. Cumbie, Devin Alexander Mourey
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Patent number: 11396014Abstract: A microfluidic movement control method utilizing light, a device, and a microtubule actuator (2). The microtubule actuator (2) is prepared by utilizing a light-induced deformed smart polymer material. The smart polymer material forms, by an exciting beam, asymmetrical deformation, and is induced to produce a capillary action to drive a microfluid movement. The embodiment can drive microfluids having various polarities and compositions, and can drive creep of the microfluid, and can even drive the microfluid to generate a 3D movement trail. The embodiment has found a wide range of potential applications in controllable microfluidic transport, micro-reaction systems, micro-mechanic systems, IC laboratories, and others.Type: GrantFiled: February 1, 2019Date of Patent: July 26, 2022Inventors: Yanlei Yu, Jiuan Lv, Jia Wei, Yuyun Liu
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Patent number: 11378571Abstract: Embodiments of the present disclosure include methods and systems for detecting the presence of endotoxins in filters. For example, embodiments of the present disclosure are directed to methods and systems for improving in-process controls by detecting undesirable quantities of endotoxins in filters containing naturally-sourced materials prior to using those filters in the production of formulated drug substances.Type: GrantFiled: April 26, 2019Date of Patent: July 5, 2022Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Nathan Mao, Annamarie Cruz, Bernhard Schilling, Scott Carver
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Patent number: 11371982Abstract: The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited.Type: GrantFiled: January 19, 2017Date of Patent: June 28, 2022Assignees: TOSOH CORPORATION, TOKYO METROPOLITAN GOVERNMENTInventors: Yasuyuki Akiyama, Atsushi Morimoto, Toru Futami, Fumiaki Koizumi, Takeshi Sawada
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Patent number: 11340244Abstract: A method and apparatus for removing magnetic beads together with molecular targets of interest from a fluid is described. A consumable bead collection probe is placed in a vessel containing magnetic beads suspended in the fluid. A magnet outside the vessel concentrates magnetic beads on a surface of the collection probe so they may be manipulated in and out of vessels during washing or processing steps without transferring the fluid into or out of a vessel. In a further embodiment, a vibrational source is attached to the collection probe such that, in combination with the magnet in a position external to the vessel, beads may be washed without releasing them from the collection probe.Type: GrantFiled: January 28, 2020Date of Patent: May 24, 2022Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Hannah Pezzi
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Patent number: 11340214Abstract: Among others, the present invention provides apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material.Type: GrantFiled: November 14, 2018Date of Patent: May 24, 2022Assignee: AnPac Bio-Medical Science Co., Ltd.Inventors: Chris C. Yu, He Yu, Xuedong Du
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Patent number: 11331665Abstract: A microfluidic centrifuge is provided that includes a microfluidic disc having a pair of through holes that include a first through hole and a second through hole, where the pair of through holes are disposed symmetric and proximal to a central axis of the microfluidics disc, where the microfluidics disc includes a sealable input port and a sealable output port, where the sealable input port and the sealable output port are connected by a microfluidics channel, and a pair of tethers disposed through the pair of through holes that are disposed to twist about each other for unwinding where the tether unwinding is disposed to interact with the through holes, where the microfluidics disc rotates about the central axis.Type: GrantFiled: January 9, 2017Date of Patent: May 17, 2022Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Manu Prakash, Mohammed Saad Bhamla, James Stanley Cybulski, Chew Chai, Aanchal Johri, Brandon Benson
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Patent number: 11331668Abstract: The invention relates to a method of performing an acoustophoretic operation, comprising the steps of: a. providing an acoustophoretic chip comprising a polymer substrate in which a microfluidic flow channel is positioned, b. providing at least one ultrasound transducer in acoustic contact with one surface of the substrate, c. actuating the at least one ultrasound transducer at a frequency f that corresponds to an acoustic resonance peak of the substrate including the microfluidic flow channel filled with a liquid suspension, and d. providing the liquid suspension in the flow channel to perform the acoustophoretic operation on the liquid suspension. The invention further relates to an acoustophoretic device, a method of producing an acoustophoretic device, and a microfluidic system comprising the acoustophoretic device.Type: GrantFiled: August 31, 2018Date of Patent: May 17, 2022Assignee: ACOUSORT ABInventors: Henrik Bruus, Rayisa Moiseyenko, Torsten Freltoft, Pelle Ohlsson, Ola Jakobsson
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Patent number: 11280766Abstract: This invention relates to encapsulated workflow reagents comprising an encapsulating material and a workflow reagent encapsulated within the encapsulating material for sample and workflow preparation prior to chromatographic, spectroscopic or other analytical systems, use thereof, and devices comprising the same.Type: GrantFiled: July 28, 2017Date of Patent: March 22, 2022Assignee: Waters Technologies CorporationInventors: Kevin Daniel Wyndham, Darryl W. Brousmiche
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Patent number: 11241688Abstract: A microfluidic system includes a microfluidic chip having a plurality of fluid channels, each fluid channel having an opening providing access to an interior of the fluid channel, and a gasket disposable on the microfluidic chip in an aligned configuration, the gasket including a first side configured to face the microfluidic chip in the aligned configuration, a second side opposite the first side, and an aperture extending through the gasket from the first side to the second side, the aperture being sized and positioned to allow a communication of pressure from the second side of the gasket to the openings of at least two fluid channels when the gasket is in the aligned configuration.Type: GrantFiled: December 5, 2019Date of Patent: February 8, 2022Assignee: 10x Genomics, Inc.Inventors: Tobias Daniel Wheeler, Rajiv Bharadwaj
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Patent number: 11169141Abstract: The invention relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second one or more sequence of measurement results, (e) comparing the change of the firType: GrantFiled: December 19, 2016Date of Patent: November 9, 2021Assignee: Radiometer Medical ApSInventors: Michael Taagaard, Peter Aage Frischauf, Flemming Aas
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Patent number: 11131608Abstract: A target analyte is extracted out of a sample fluid in a sample fluid passage by diffusing the target analyte through a supported liquid membrane to a product fluid passage. Extraction of the target analyte is accelerated by applying an electric field across and perpendicular to the supported liquid membrane with electrodes. Passage of selected ions across an exchange membrane extending between one of the electrodes and the supported liquid membrane is inhibited.Type: GrantFiled: October 23, 2015Date of Patent: September 28, 2021Assignee: Hewlett-Packard Development Company, L.P.Inventors: Viktor Shkolnikov, Anita Rogacs
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Patent number: 11073522Abstract: The structures of very long chain dicarboxylic acids from blood samples may be validated through chemical derivatization of the dicarboxylic functionality with 2-picolylamine before positive ESI mass spectroscopy analysis. Laboratory standards may be used to quantify the concentration of the selected very long chain dicarboxylic acid in a blood sample.Type: GrantFiled: May 3, 2018Date of Patent: July 27, 2021Assignee: Lincoln Memorial UniversityInventor: Paul L. Wood
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Patent number: 11067576Abstract: A method for monitoring health maintenance by collecting an initial blood sample from an individual and dividing the collected blood sample into at least two parts. The first of the two parts is immediately analyzed for multiple blood components levels, and the second part is frozen immediately after the collection to be used at a later time as a comparative standard. After a period of time, a second blood sample is collected from the same individual and analyzed for the same multiple blood components levels in a parallel test with the frozen part. The results obtained from the second blood sample are then compared to the results from the frozen comparative standard to detect real changes in the multiple blood components levels over time.Type: GrantFiled: March 9, 2018Date of Patent: July 20, 2021Inventor: Martin King
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Patent number: 11054410Abstract: An accessory (800) is provided for a mobile device (102) to measure characteristics of a test strip (808). The accessory (800) includes a test strip adapter (806), a phone adapter (802), and a coupler (804). The test strip adapter (806) includes a test strip attachment for a test strip type and a first interlock shared with other test strip adapters for other test strip types. The phone adapter (802) includes a phone attachment for a mobile device model and a second interlock shared with other phone adapters for other mobile device models. The coupler (804) includes a third interlock that forms a first mating pair with the first interlock of the test strip adapter (806), and a fourth interlock that forms a second mating pair with the second interlock of the phone adapter (802).Type: GrantFiled: September 14, 2016Date of Patent: July 6, 2021Inventors: Yenyu Chen, Tungmeng Tsai, Chieh Hsiao Chen, Yaoching Tsai, Tangan Liu
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Patent number: 11047838Abstract: The invention relates to a method for elemental analysis, in particular for determining carbon and nitrogen in a sample, an apparatus suitable for said method, and the use of a catalyst suitable for said method, the catalyst being a metal oxide catalyst comprising oxides of Ce, Cu and Mn.Type: GrantFiled: January 18, 2017Date of Patent: June 29, 2021Inventors: Werner Küppers, Jan Macke
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Patent number: 11041805Abstract: A method (100) and a system for determining pH values of fermented/acidified animal/vegetable milk products from inline optical measurements, the method comprising: emitting light into a fermented/acidified animal/vegetable milk product (101); optically detecting scattering light coming from said fermented/acidified animal/vegetable milk product, generated from said emitted light once received therein, to collect scattered light data (102); calculating by a computing device including one or more processors running an algorithm at least one value of a variable from the collected scattered light data (103); and obtaining, by said computing device a pH value of the fermented/acidified animal/vegetable milk product by using said at least one calculated value of a variable (104), wherein a single wavelength is used for collecting the scattered light data.Type: GrantFiled: November 24, 2016Date of Patent: June 22, 2021Assignee: UNIVERSITAT AUTONOMA DE BARCELONAInventors: Manuel Castillo Zambudio, Oscar Arango Bedoya, Antonio José Trujillo Mesa
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Patent number: 11033902Abstract: A microfluidic device (1) comprising, a pallet, having a first surface (4a) and second, opposite, surface (4b); the first surface (4a) having defined therein, a main channel (5), and one or more inlet subsidiary channels (6a,6b) each of which is in fluid communication with the main channel (5) at a first junction (7) which is located at one end of the main channel (5), and corresponding one or more outlet subsidiary channels (8a,8b) each of which is in fluid communication with the main channel (5) at a second junction (9) which is located an second, opposite, end of the main channel (5); wherein the depth (‘d’) of the one or more inlet subsidiary channels (6a,6b) and the depth (‘?’) of the one or more outlet subsidiary channels (8a,8b) is less than the depth (‘f) of the main channel (5) so that there is step (106a,106b, 108a, 108b) defined at the first junction (7) and at the second junction (9); the second, opposite, surface (4b) having defined therein a groove (15) which can receive a means for generating aType: GrantFiled: November 30, 2015Date of Patent: June 15, 2021Assignee: RQMICRO AGInventors: Daniel Schaffhauser, Hans-Anton Keserue, Georgios Akepsimaidis