Patents Examined by Jeanette Lieb
  • Use of nutritional supplement for increasing the bacterial mass in the rumen of a ruminant
    Patent number: 9676838
    Abstract: Use of a nutritional supplement for increasing the bacterial mass in the rumen of a ruminant. The nutritional supplement includes proteins with a degree of hydrolysis above 28% and has more than 23 mg ?-amino nitrogen per gram of protein. The hydrolyzed proteins are preferably hemoglobin.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 13, 2017
    Assignee: APC EUROPE S.A.
    Inventors: Francisco Javier Polo Pozo, Carmen Rodriguez Canel, Alejandro Bach Ariza, Anna Aris Giralt
  • Methods for synthesizing amatoxin building block and amatoxins
    Patent number: 9676702
    Abstract: The invention relates to novel methods for synthesizing a synthon for ?,?-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: June 13, 2017
    Assignee: Heidelberg Pharma GmbH
    Inventors: Christian Lutz, Christoph Mueller, Werner Simon
  • Fibrin microthreads
    Patent number: 9662415
    Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: May 30, 2017
    Assignee: WORCESTER POLYTECHNIC INSTITUTE
    Inventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
  • Metabolic imprinting effects of specifically designed lipid component
    Patent number: 9649286
    Abstract: The invention relates to the use of specifically designed lipid component with optimal fatty acid profile, an enhanced portion of the palmitic acid residues in the sn-2 position and present as lipid globules with a phospholipid coating for an early in life diet for improving the development of a healthy body composition, in particular prevention of obesity, later in life.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: May 16, 2017
    Assignee: N.V. Nutricia
    Inventors: Eline Marleen Van Der Beek, Marieke Abrahamse-Berkeveld, Annemarie Oosting, Martine Sandra Alles
  • Cathelicidin as novel inflammatory bowel disease marker and therapy for colitis associated intestinal fibrosis
    Patent number: 9651562
    Abstract: Method of diagnosing and treating inflammatory bowel disease are disclosed herein. Inflammatory bowel disease can be treated and diagnosed using cathelicidin peptides and detection agents thereof. Specifically, method of treating and diagnosing Crohn's disease and ulcerative colitis are disclosed herein.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: May 16, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Hon Wai Koon, Charalabos Pothoulakis
  • Nutritional composition for improving muscle function and daily activity
    Patent number: 9642390
    Abstract: The invention relates to a nutritional composition comprising (a) at least 18 en % of proteinaceous matter, said proteinaceous matter comprising whey; (b) at least 12 wt % of leucine, based on total proteinaceous matter; and (c) a lipid fraction comprising at least a ?-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid for improving the muscle function in a mammal, for improving daily activity, for improving physical performance, for providing a better prognosis in terms of extended life-expectancy, for improving compliance to an anti-cancer therapy or for improving a quality of life.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: May 9, 2017
    Assignee: N.V. Nutricia
    Inventors: Klaske van Norren, Adrianus Lambertus Bertholdus van Helvoort, Joyce Faber, Robert Johan Joseph Hageman, Arjan Paul Vos
  • Processes for producing protein microparticles
    Patent number: 9643996
    Abstract: Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed. The resulting protein microparticles retain high specific activity without the need for large amounts of stabilizing excipients.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: May 9, 2017
    Assignee: Battelle Memorial Institute
    Inventors: Trevor Petrel, Craig Bartling, Lena Furci, Carrie Howland
  • Peptides for enhancing transdermal delivery
    Patent number: 9642895
    Abstract: Skin penetration enhancers comprising peptides are disclosed. Compositions comprising the skin penetration enhancers are also provided. The compositions further comprise an active agent, such as a pharmaceutically active agent, a vaccine, a cosmetic agent, and a. nutritional supplement. Methods of transdermal ly delivering a pharmaceutically active agent, a vaccine, a cosmetic agent, or a nutritional supplement are also provided.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: May 9, 2017
    Assignee: 3M Innovative Properties Company
    Inventors: Minghua Dai, Dmitri V. Smirnov, Paul D. Wightman
  • Peptide and peptidomimetic inhibitors
    Patent number: 9644004
    Abstract: The present invention provides inhibitors and/or antagonists of plasma kallikrein. Also provided are methods of utilizing the inhibitors as therapeutics.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 9, 2017
    Assignee: Ra Pharmaceuticals, Inc.
    Inventors: Zhaolin Wang, Ping Ye, Alonso Ricardo, Kristopher Josephson, Paul Anderson, Michelle Denise Arata, Zhong Ma, Nathan Ezekiel Nims, Eberhard Schneider, Gregor Schurmann, Peter Wagner, Douglas A. Treco, Hong Zheng, Daniel Elbaum, Nicolas Cedric Boyer
  • Insulin derivatives having an extremely delayed time-action profile
    Patent number: 9644017
    Abstract: The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 9, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Paul Habermann, Gerhard Seipke, Roland Kurrle, Gunter Muller, Mark Sommerfeld, Norbert Tennagels, Georg Tschank, Ulrich Werner
  • Stable compositions of peptide epoxy ketones
    Patent number: 9636376
    Abstract: The invention relates to pharmaceutical compositions that provide improved solubility and stability for peptide epoxy ketones. More specifically, the invention relates to pharmaceutical compositions comprising the peptide epoxy ketone proteasome inhibitor carfilzomib.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: May 2, 2017
    Assignee: InnoPharma, Inc.
    Inventors: Ketan Hippalgaonkar, Kumaresh Soppimath, Satish Pejaver, Navneet Puri
  • Products and methods for aortic abdominal aneurysm
    Patent number: 9629891
    Abstract: This invention relates to the treatment of aortic abdominal aneurysm. In particular, the invention relates to products and methods that inhibit Notch signaling to treat a patient developing or suffering from an aortic abdominal aneurysm.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: April 25, 2017
    Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Chetan Hans, Vidu Garg
  • Methods for synthesizing amatoxin building block and amatoxins
    Patent number: 9630907
    Abstract: The invention relates to novel methods for synthesizing a synthon for ?,?-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: April 25, 2017
    Assignee: Heidelberg Pharma GmbH
    Inventors: Christian Lutz, Christoph Mueller, Werner Simon
  • Antifouling materials
    Patent number: 9631100
    Abstract: The invention provided herein presents a novel family of antifouling agents based on hydroxylated and fluorinated compounds.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: April 25, 2017
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventor: Meital Reches
  • Cytotoxic T lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer
    Patent number: 9624284
    Abstract: The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as pancreatic carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against pancreatic and other cancers.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: April 18, 2017
    Assignee: Immunotope, Inc.
    Inventor: Ramila Philip
  • Short peptides and a method of use as an antioxidant
    Patent number: 9624265
    Abstract: A method for attenuating effects of free radicals on a keratinous material of a subject in need thereof, comprising applying a composition to the keratinous material is provided. The composition comprises a physiologically or pharmaceutically acceptable medium and a short chain polypeptide having four amino acid units of a specific formula. The composition may be a sunscreen, a skin cream, a shampoo or a hair conditioner.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 18, 2017
    Assignee: L'OREAL
    Inventor: Anne Young
  • Targeted pharmacological chaperones
    Patent number: 9610358
    Abstract: The present invention relates to the preparation and use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as specific cellular organelles. In particular, the therapeutic compounds of the invention are specific for modifying enzyme activity within targeted organelles or structures of cells and tissues. Subcellular organelles and structures that may be specifically targeted by compounds of the present invention include lysosomes, autophagasomes, the endoplasmic reticulum, the Golgi complex, peroxisomes, the nucleus, membranes and the mitochondria.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: April 4, 2017
    Assignee: Marker Gene Technologies, Inc
    Inventors: John Joseph Naleway, Fiona Karen Harlan, Jason Scott Lusk
  • Methods for preventing or treating disorders by increasing bioavailability of iron and related pharmaceutical formulation
    Patent number: 9610356
    Abstract: The present disclosure relates to methods of treating, ameliorating or preventing a disorder comprising administering a therapeutically effective amount of a composition to a subject in need thereof, which composition contains a lipocalin mutein or a fragment or a variant thereof capable of increasing the bioavailability of iron in the subject.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: April 4, 2017
    Assignee: Pieris Pharmaceutical GmbH
    Inventors: Andreas Hohlbaum, Hendrik Gille, Stefan Trentmann, Laurent Audoly, Andrea Allensdorfer
  • Nutritive proteins and methods
    Patent number: 9605040
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 28, 2017
    Assignee: Axcella Health Inc.
    Inventors: Geoffrey von Maltzahn, Michael J. Hamill, Rajeev Chillakuru, John F. Kramarczyk, David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver
  • Glycopeptide constructs and uses thereof
    Patent number: 9598466
    Abstract: Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic peptide scaffolds that display carbohydrate antigens in a clustered fashion. The immunogenicity of select glycopeptide conjugates is demonstrated.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: March 21, 2017
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Jianglong Zhu, Dongjoo Lee, Philip Livingston, Govind Ragupathi