Abstract: A method and system of treating connective tissue to alter the biomechanical and fundamental properties of the connective tissue by forming perforations in the connective tissue to at least 90% of the depth or thickness of the connective tissue and maintaining the perforations in the connective tissue. The method alters the tissue to enhance the fundamental mechanisms involved in the immunology, biochemistry, and molecular genetics of the metabolism of the connective tissue. The connective tissue may be any desired connective tissue. The connective tissue of the eye may be removed to form a first desired pattern of perforations in the connective tissue of the eye at a first distance from the corneal center of the eye. Connective tissue is removed from the eye to form a second desired pattern of perforations in the tissue of the eye at a second distance from the corneal center of the eye.

Abstract: A laser system has a laser source generating a laser beam, wherein the laser source is adapted for medical removal of body tissue by the laser beam within a predetermined treatment contour. A guide frame in the shape of the treatment contour is provided. A scanner is provided for completely scanning a base surface of the guide frame with the laser beam, wherein the scanner is arranged between the laser source and the guide frame in a path of the laser beam.

Abstract: A surgical system that ablates soft tissue. The system may include a fiber laser oscillator as the gain medium that emits electromagnetic radiation. The system may process the electromagnetic radiation, and direct the electromagnetic radiation on to the soft tissue to be ablated. Due at least in part to the nature of the electromagnetic radiation emitted by the fiber laser oscillator, the system may provide various enhancements, such as a higher power conversion efficiency, a longer lifetime, less heat dissipation, a more compact design, and/or other enhancements, for example. The system may also generate electromagnetic radiation with a relatively high beam quality. This may reduce beam divergence and beam spot size on targeted soft tissue, thereby enhancing power density in the electromagnetic radiation guided to the soft tissue. This enhanced power density may facilitate effective ablation.

Abstract: The invention provides surgical or diagnostic tools and associated methods that offer improved user control for operating remotely within regions of the body, and improved methods of assembling the tools. In some embodiments these tools include a proximally-located actuator for the operation of a distal end effector, as well as proximally-located actuators for articulational and rotational movements of the end effector. Control mechanisms and methods refine operator control of end effector actuation and of these articulational and rotational movements. The articulation mechanisms comprise pairs of links, one link distal and the other proximal, configured such that movement of a proximal link is transferred to the distal link by way of tension bearing members. Embodiments of the invention include a guide for such tension bearing members that facilitates assembly of the tool. Embodiments also include improved methods for attaching tension bearing members to the links.

Abstract: The present disclosure relates to dressings, such as patches and bandages, and other devices and systems that deliver nitric oxide.

Abstract: A mitral hook instrument for use particularly in heart valve operations. The mitral hook is used in particular for grasping or hooking secondary chords for lysis procedures. The interior surface of the hook has a groove or channel to facilitate use of a scalpel to cut a chord or other member which has been grasped and exposed by the hook. Also, markings are preferably provided on the distal end of the mitral hook instrument in order to assist the surgeon.

Abstract: An endoscope of the invention is the endoscope for applying a propulsion force in a direction of insertion axis of an insertion portion main body in accordance with rotation of the insertion portion main body based on driving force of a driving member, and the endoscope includes a flexible elongated inner layer tube configured as a shaft of the insertion portion; and a spiral-shaped portion rotatable around the inner layer tube as an axial center based on the driving force of a motor, the spiral-shaped portion forming an outer surface of the insertion portion main body, in which the spiral-shaped portion is formed by a nondensely wound coil and a resin thin film provided so as to cover gaps of a wire forming the metal coil.

Abstract: Devices and methods having a cooling material and reduced pressures to treat biological external tissue using at least one energy source are disclosed. The cooling material may be water, ethyl alcohol, and/or any other material having a vapor pressure below atmospheric pressure. The energy source may be incoherent light, coherent light, a radio frequency, ultrasound, a laser, and/or any other type of energy that can be applied through the device. The features of various embodiments of the device include the generation of positive pressure and/or negative pressure through one or more pressure conduits, the application of an object within a recess of the device, and measurements through various sensors on the device. These sensors may be monitored and/or controlled through a display element having rows and columns of pixels on the device.

Abstract: In one embodiment of the invention, an apparatus is provided including a linkage and a balancing mechanism coupled to the linkage around a pivotal joint. The linkage couples to a support structure at a first end and support a weight applied to a second end. The balancing mechanism counter balances the weight applied to the second end of the linkage. As the linkage is deformed to vertically adjust the height of the weight with a different moment arm length, the balancing mechanism varies a cable path length to modify the compression of a spring and a tension in a cable to adjust the amount of counter balance force applied to the linkage.

Abstract: A cochlear implant placed in a cochlea of a living subject for stimulating the auditory system of the living subject, where the auditory system comprises auditory neurons. In one embodiment, the cochlear implant includes a plurality of light sources, {Li}, placeable distal to the cochlea, each light source, L1, being operable independently and adapted for generating an optical energy, Ei, wherein i=1, . . . , N, and N is the number of the light sources, and delivering means placeable in the cochlea and optically coupled to the plurality of light sources, {Li}, such that in operation, the optical energies {Ei} generated by the plurality of light sources {Li} are delivered to target sites, {Gi}, of auditory neurons, respectively, wherein the target sites G1 and GN of auditory neurons are substantially proximate to the apical end and the basal end of the cochlea, respectively.

Abstract: A robotic control system is placed in clutch mode so that a slave manipulator holding a surgical instrument is temporarily disengaged from control by a master manipulator in order to allow manual positioning of the surgical instrument at a surgical site within a patient. Control systems implemented in a processor compensate for internally generated frictional and inertial resistance experienced during the positioning, thereby making movement more comfortable to the mover, and stabler from a control standpoint. Each control system drives a joint motor in the slave manipulator with a saturated torque command signal which has been generated to compensate for non-linear viscous forces, coulomb friction, cogging effects, and inertia forces subjected to the joint, using estimated joint angular velocities, accelerations and externally applied torques generated by an observer in the control system from sampled displacement measurements received from a sensor associated with the joint.

Abstract: A laser system that includes a diode pump source. A frequency doubled solid state visible laser is pumped by the diode pump source and produces a pulsed laser output with a train of pulses. Resources provide instructions for the creation of the pulsed output, with on and off times that provide for substantial confinement of thermal effects at a target site. This laser system results in tissue specific photoactivation (or TSP) without photocoagulation damage to any of the adjacent tissues and without causing full thickness retinal damage and the associated vision loss.

Abstract: A method for combining the effective modalities of electrotherapy and phototherapy is provided. A medical electrode assembly is substantially transparent or translucent to visible, infrared and/or ultraviolet light so that light rays emitted by a phototherapy device can shine through and pass transversely across every layer of the medical electrode assembly to impinge upon the skin of the patient to which the assembly is attached. This includes an area of skin located directly underneath the medical electrode assembly and thereby enables the combination therapy to be achieved.

Abstract: A corneal surgery apparatus capable of accurately measuring a three-dimensional corneal shape in a state of being subjected to corneal ablation. The apparatus has a unit including a laser source emitting a laser beam to bring about corneal ablation and a first optical system irradiating a cornea with the beam, a unit including a light source emitting measurement light with a wide wavelength band, a beam splitter dividing the light, a second optical system irradiating the cornea with one divided light, a movable reference mirror on an optical path of the other divided light and a photo-detector at a position photo-receiving interference light of the measurement light reflected by the cornea and the mirror, which obtains a three-dimensional corneal shape based on an interference light image, a unit obtaining corneal ablation data based on obtained corneal shape data, and a unit controlling the ablation unit based on the ablation data.

Abstract: An apparatus for treating skin includes a chamber defined by a surface and a rim extending from the surface. A source of vacuum is capable of removing air from inside the chamber so that air outside the chamber flows into the chamber. Impedance of the air flowing between the rim of the chamber positioned adjacent the skin surface causes the pressure inside the chamber to decrease relative to ambient. A pressure sensor can determine when the pressure inside the chamber decreases to a threshold value. A controller can receive a signal from the pressure sensor when the threshold value is reached, which causes the rate of removal of the air from inside the chamber by the source of vacuum to be increased. The rim of the chamber forms a substantially fluid tight seal with the skin. The skin is drawn toward an inner surface of the chamber.

Abstract: A method of reducing hair growth includes topical application of a TRPM8 and/or a TRPA1 agonist, alone or in conjunction with heat.

Abstract: The manipulator has two-degree-of-freedom of rotation and gripping, and is capable of ensuring force feedback or force sensation with excellent operationability. A link mechanism 3 is provided between an operation part 1 and a working part 2. The link mechanism 3 has four driving rods 3a to 3d and first and second coupling members of the sane structure, 41, 42 provided at opposite ends of the driving rods. First and second working members 2a, 2b move correspondingly to the operation of first and second operating members 1a, 1b with the aid of the link mechanism 3. The first and second working member can open and close, change the yaw angles and the pitch angles in response to the same action of the first and second operating member through the link mechanism.

Abstract: A system and method for performing laser induced optical breakdown (LIOB) in corneal tissue of an eye requires calculating a pattern of focal spots. LIOB is then induced at a first focal spot, and is continued at a plurality of interim focal spots within a time period ?. Each focal spot has a diameter “d1” and generates a temporal cavitation bubble of diameter “d2”. It then collapses within time “?” to a substantially stationary diameter “d3”, with (d1?d3?d2). Importantly, each focal spot is located more than “d2” from every other interim focal spot within the time period of “?”. At the time “?”, a second focal spot in the pattern can be generated at a distance “d3” from the first focal spot. This process is then continued with another plurality of interim focal spots being generated within another time period “?”.

Abstract: A method for performing intrastromal ophthalmic laser surgery requires Laser Induced Optical Breakdown (LIOB) of stromal tissue without compromising Bowman's capsule (membrane). In detail, the method creates cuts in the stroma over all, or portions of, a plurality of concentric cylindrical surfaces (circular or oval). Importantly, these cuts are all centered on the visual axis of the patient's eye. In accordance with the present invention, cuts can be made either alone or in conjunction with the removal of predetermined volumes of stromal tissue. The actual location of cuts in the surgery will depend on whether the treatment is for presbyopia, myopia, hyperopia or astigmatism.

Abstract: The present invention provides a robotic surgical tool for use in a robotic surgical system to perform a surgical operation. The robotic surgical tool includes a wrist mechanism disposed near the distal end of a shaft which connects with an end effector. The wrist mechanism includes a distal member configured to support the end effector, and a plurality of rods extending generally along an axial direction within the shaft and movable generally along this axial direction to adjust the orientation of the distal member with respect to the shaft. Advancement or retraction of a first rod generally along the axial direction tips the base through a first angle. The addition of a second angle allows the distal member to direct the end effector in essentially a compound angle. The robotic surgical tool may also include provisions for roll movement.