Patents Examined by Jerome D. Goldberg
  • Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
    Patent number: 6569853
    Abstract: The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: May 27, 2003
    Assignee: CombinatoRx, Incorporated
    Inventors: Alexis Borisy, Curtis Keith, Michael A. Foley, Brent R. Stockwell
  • Therapeutic and prophylactic agents for neoplasms
    Patent number: 6569877
    Abstract: This invention relates to therapeutic and prophylactic agents for neoplasms which comprise a fused heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient; to the use of such a compound in the preparation of a medicament for the treatment and prevention of neoplasms; and to a method for treatment and prevention of neoplasms which comprises administering a pharmaceutically effective amount of such a compound to a warm-blooded animal (preferably a human).
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: May 27, 2003
    Assignee: Sankyo Company, Limited
    Inventors: Shinichi Kurakata, Kosaku Fujiwara, Takashi Fujita
  • Malignant tumor metastasis inhibitors
    Patent number: 6566351
    Abstract: Pharmaceutical agents containing a compound of the general formula (I): wherein R1 represents —O—R2, —S—R2, —CH2—R2 or —CH═R2 where R2 represents a C1-C10 chain hydrocarbon group which may be substituted by one or more hydroxyl groups, and R3 represents a hydrogen atom or a hydroxyl group are useful as malignant tumor metastasis inhibitors without any especially strong side effects.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: May 20, 2003
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Etsuro Ogata, Kyoji Ikeda, Koichi Endo
  • Treatment of hepatic cirrhosis
    Patent number: 6562829
    Abstract: A composition for treating hepatic fibrosis and a method of using and manufacturing the composition are provided. The composition includes a quinazolinone derivative, preferably Halofuginone.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: May 13, 2003
    Assignees: Hadasit Medical Research Services & Development Co., Ltd., Agricultural Research Organaization-Ministry of Agriculture
    Inventors: Mark Pines, Arnon Nagler
  • Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives
    Patent number: 6562830
    Abstract: Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: May 13, 2003
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Pharmaceutical composition for and method of treating leukemia
    Patent number: 6552059
    Abstract: Method of treating leukemia, inhibiting the growth or proliferation of leukemic cells or extending the life span of a animal having leukemia are disclosed. The methods comprise the step of treating the leukemia with an effective amount of a compound of the Formula I or a pharmaceutically acceptable salt or prodrug form thereof, wherein: X is hydrogen, halogen or alkyl of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; R is hydrogen or an alkyl group of from 1 to 8 carbon atoms, alkylcarbamyl; R2 is 4-thiazolyl or NHCOOR1; and R1 is an aliphatic hydrocarbon of less than 7 carbon atoms. A chemotherapeutic agent and/or potentiator can be used in conjunction with the compound of the Formula I.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: April 22, 2003
    Assignee: University of Arizona Foundation
    Inventor: James Berger Camden
  • Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
    Patent number: 6548488
    Abstract: The present invention relates to therapeutic associations for the treatment of cancer, comprising an effective amount of a camptothecin, or a camptothecin derivative, with an effective amount of an alkylating agent, such as melphalan, dacarbazine, or cyclophosphamide, and methods of using such therapeutic associations.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: April 15, 2003
    Assignee: Aventis Pharma S.A.
    Inventor: Marie-Christine Bissery
  • Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
    Patent number: 6545010
    Abstract: The present invention relates to therapeutic associations for the treatment of cancer, comprising an effective amount of a camptothecin, or a camptothecin derivative, with an effective amount of an alkylating agent such as a platin derivative, and methods of using such therapeutic associations.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: April 8, 2003
    Assignee: Aventis Pharma S.A.
    Inventor: Marie-Christine Bissery
  • Use of etodolac for the treatment of chronic lymphocytic leukemia
    Patent number: 6545034
    Abstract: A method of treating cancer is provided comprising administering an amount of etodolac to a subject afflicted with cancer that is effective to reduce the viability and/or to sensitize the cancer to an anti-cancer agent.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: April 8, 2003
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Soichi Adachi, Lorenzo M. Leoni
  • Carboxylic acid derivatives as inhibitors of hyperproliferation diseases
    Patent number: 6541495
    Abstract: A method of treating hyperproliferation diseases in mammals in need of such treatment, which method includes administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein R1, R2, R3, R4, W, X, Y, Z and t are as defined herein.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: April 1, 2003
    Assignee: Pfizer INC
    Inventors: Steven W. Goldstein, Kelly P. Longo, Bernard Hulin
  • Uses of diterpenoid triepoxides as an anti-proliferative agent
    Patent number: 6537984
    Abstract: Combinations of diterpenoid triepoxides and anti-proliferative agents are used in a combination therapy to treat hyperproliferative disorders. Anti-proliferative agents of interest include agents active in killing tumor cells, as well as immunosuppressants, and a variety of other agents that reduce cellular proliferation in targeted tissues. Synergistic combinations provide for comparable or improved therapeutic effects, while lowering adverse side effects.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: March 25, 2003
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Pharmagenesis
    Inventors: Glenn D. Rosen, Edwin S. Lennox, John H. Musser
  • Method and compositions for maintaining glomerular filtration rate while inhibiting extracellular matrix accumulation
    Patent number: 6531482
    Abstract: This invention provides a method of and compositions for increasing or maintaining glomerular filtration rate while preserving renal structure in a patient comprising administering an angiotensin II type 1 vascular receptor antagonist to the patient, independent of its effects on systemic blood pressure. The invention provides that, by administering the AII type 1 receptor antagonist, blood flow to the kidney can be improved without sacrificing intraglomerular pressure and therefore glomerular filtration and that even with this enhanced glomerular pressure and filtration, renal structure is preserved.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: March 11, 2003
    Assignee: Vanderbilt University
    Inventors: Valentina Kon, Agnes Fogo, Iekuni Ichikawa
  • Pharmaceutical compositions containing cinchonine dichlorhydrate
    Patent number: 6528524
    Abstract: The invention relates to pharmaceutical compositions containing cinchonine dihydrochloride as active ingredient with a purity of at least 95%. The invention also relates to a process for preparing cinchonine dihydrochloride from cinchonine and the use of pharmaceutical compositions containing cinchonine dihydrochloride for treating multiple drug resistance.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: March 4, 2003
    Assignee: Debiopharm SA
    Inventors: Philippe Genne, Houssam Ibrahim
  • Synergistic compositions for the selective control of tumor tissue
    Patent number: 6525038
    Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: February 25, 2003
    Inventor: Werner Kreutz
  • Apoptosis inducer
    Patent number: 6525082
    Abstract: A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: February 25, 2003
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Tatsuji Enoki, Nobuto Koyama, Katsushige Ikai, Ikunoshin Kato
  • Carcinostatic substance for compatible administration, process of administrating same and process of rapidly inspecting same
    Patent number: 6518278
    Abstract: Disclosed herein are a process of compatibly administrating a carcinostatic substance with cis-oxalato (1R,2R-diaminocyclohexane) Pt (II), or a certain platinum complex, and a carcinostatic substance which may be employed in the above process. The combination of the carcinostatic substance, for example, 5-fluorouracil and the above platinum complex in accordance with present invention promotes the anticancer property of the carcinostatic substance.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: February 11, 2003
    Assignee: Debio Pharm S.A.
    Inventors: Masao Oguro, Junji Ohnishi
  • Cancer treatments and pharmaceutical compositions therefor
    Patent number: 6506783
    Abstract: A pharmaceutical composition that inhibits the growth of tumors and cancers in mammals and can be used to treat viral infections that comprises a fungicide is disclosed. The particular fungicide used is a benzimidazole derivative having the formula: wherein R is selected from the group consisting of H, carboxyl (—CO2H), hydroxyl, amino or esters (—CO2R′) wherein R′ is selected from the group consisting of alkoxy, haloalkyl, alkenyl, and cycloalkyl wherein the alkyl groups have from 1-8 carbons or CH3CH2(OCH2CH2)n—or CH3CH2CH2(OCH2CH2CH2)n—or (CH3)2CH—(OCH(CH3)CH2)n—wherein n is from 1-3, the pharmaceutically acceptable salts thereof, or mixtures thereof.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: January 14, 2003
    Assignee: The Procter & Gamble Company
    Inventor: James Berger Camden
  • Composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
    Patent number: 6503889
    Abstract: Therapeutic pharmaceutical compositions comprising a pyrimidine derivative in combination with camptothecin or a camptothecin derivative for the treatment of cancer are described. In one embodiment, the pyrimidine derivative is capecitabine and the camptothecin derivative is CPT-11.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: January 7, 2003
    Assignee: Aventis Pharma S.A.
    Inventor: Marie-Christine Bissery
  • Synergistic tumorcidal response induced by histamine
    Patent number: 6498181
    Abstract: The present invention relates to methods of treating cancer in which histamine is administered in conjunction with other cancer therapies. The cancer therapy includes surgery, radiation, immunotherapy, the administration of an agent which enhances the humoral immune response of the patient or any combination thereof.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: December 24, 2002
    Assignee: Maxim Pharmaceuticals
    Inventors: Kurt R. Gehlsen, Kristoffer Hellstrand, Svante Hermodsson
  • Methods of treatment for cancer or viral infections
    Patent number: 6498188
    Abstract: Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: December 24, 2002
    Assignee: The Procter & Gamble Company
    Inventor: James Berger Camden