Abstract: Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

Abstract: The present invention provides preservative compositions suitable for replacing, partially or in totality, conventional preservatives in skin care and hygiene cosmetic or pharmaceutical products. The preservative formulations include an organic carboxylic acid present in a concentration from about 0.01 to about 30 wt./wt. % of the formulation, an alcohol present in a concentration from about 0.01 to about 60 wt./wt. % of the formulation. The formulations include an inorganic salt present in a concentration from about 0.01 to about 80 wt./wt. % of the formulation, and a chelating agent present in a concentration from about 0.01 to about 20 wt./wt. % of the formulation.

Abstract: The invention provides a liquid composition containing (a) an acidic oxidant, (b) nitric acid or a salt thereof, and (c) at least one carboxylic acid selected from the group consisting of monocarboxylic acids, dicarboxylic acids, and tricarboxylic acids, or a salt thereof. The liquid composition can be used to disinfect or sterilize a subject that includes a portion made of an aluminum-based metal.

Abstract: Certain exemplary embodiments can provide a composition of matter comprising chlorine dioxide dissolved in acetic acid. When stored, a concentration of the chlorine dioxide in the composition of matter can be retained, with respect to an initial concentration of chlorine dioxide in said composition of matter, at, for example, greater than 30% for at least 28 days. Certain exemplary embodiments can provide a method comprising releasing chlorine dioxide from a composition comprising chlorine dioxide dissolved in acetic acid.

Abstract: An anti-stick agent that may be incorporated into an aqueous medium to assist in the prevention of soils and bodily exudates adhering to the skin. A substrate may be utilized to assist in delivering the anti-stick agent to the skin.

Abstract: Coatings for medical devices, methods of making the coatings, and methods of using them are described.

Abstract: A microbicidal disinfecting composition and a method of preparing the same include the use of an acidifying agent that comprises at least one of an alkali metal bisulfate, ammonium bisulfate, or a combination thereof. The composition has broad-spectrum microbicidal properties and does not demonstrate cloudiness or precipitation when prepared, diluted, or otherwise exposed to hard water.

Abstract: Salicylic acid esters of resveratrol and topical compositions containing same.

Abstract: A balanced redox-signaling compound with reactive molecules that mimic those naturally occurring inside cells that have been precisely stabilized and formulated as a supplement for oral consumption acting to enhance proper immune system function, enhance the efficiency and production of the body's native antioxidants as well as enhance the performance of intercellular communications involved in healthy tissue maintenance and athletic performance.

Abstract: The invention relates to a cosmetic sun protection product based on W/Si emulsions, which product has improved effectiveness and, despite high content of organic sun protection filters, a very good sensory profile and, in particular, a long-lasting soft touch. The sun protection product includes 22-32 wt. % of a volatile, cyclic silicone oil, 2.0-4.0 wt. % of a non-volatile silicone elastomer, 0.9-2.8 wt. % of an emulsifier, 0.1-0.5 wt. % of an amino acid/fatty acid copolymer, 19-24 wt. % of a mixture of organic UVA and UVB filters at a ratio of from 1:1.5 to 1:1; and cosmetic adjuvants, excipients, active substances and mixtures thereof to make 100 wt. %, the Brookfield viscosity of the sun protection product ranging from 3,000 to 20,000 mPas.

Abstract: A powder cosmetic composition having satisfactory usability, cosmetic durability, adhesion properties to the skin, slip properties and smoothness comprising, as powder components (a) and (b): (a) a branched alkyl silicone-treated powder and (b) a composite silicone elastomer powder coated on all or part of the powder surface with at least one coating selected from the group consisting of clay minerals, resins, metal oxides and salts, in particular including 3 to 80 mass % of the component (a) and 1 to 30 mass % of the component (b).

Abstract: An improved method and apparatus for producing a stable, non-toxic, antimicrobial electrolyzed saline solution with a broad range of anti-infective and therapeutic applications. The resulting electrolyzed saline solution exhibits a marked lack of toxicity upon intravenous, aspired, oral or topical application in mammals for therapeutic applications providing a broad platform, including topical disinfection, antimicrobial application, wound treatment, oxidative stress reduction and enhancement of immune function to better detect malfunctioning cells.

Abstract: Disclosed herein are tablets comprising ezatiostat hydrochloride wherein the ezatiostat hydrochloride comprises from about 75 to about 82 percent by weight of the tablet.

Abstract: Ascorbic acid esters of resveratrol and topical compositions containing same.

Abstract: The present invention provides preservative compositions suitable for replacing, partially or in totality, conventional preservatives in skin care emulsions and heavy duty hand cleansers comprised of alternative molecular compounds than found in conventional preservative formulations. The preservative formulation for skin care formulations includes a fatty acid and/or ester of fatty acid present in a concentration from about 0.01 wt./wt. % to about 90 wt./wt. % of the formulation, one or more alcohols in a concentration from about 0.01 to about 60 wt./wt. % of the formulation, and a chelating agent present in a concentration from about 0.01 to about 20 wt./wt. % of the blend.

Abstract: An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 ?m, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.

Abstract: The present invention generally relates to methods and compositions for treating pathogenic vaginal biofilms. More specifically, the invention relates to pharmaceutical compositions comprising a combination of boric acid and diethylaminetetracetic acid (EDTA) and to methods of using such compositions to treat or prevent biofilm formation associated with vaginal infections, such as bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), trichomoniasis or mixed infections.

Abstract: A hydrophilic vehicle-based dual controlled-release matrix system, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a solution or a suspension, which allows for easier formulation of low dose compounds. The matrix includes two rate controlling barriers for the controlled release of one or more pharmaceutically active agents. The primary rate controlling barrier includes a hydrophilic vehicle. The primary rate controlling barrier can further comprise one or more solvents which are miscible with the hydrophilic vehicle. The secondary rate controlling barrier includes a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle. The presence of the hydrogel-forming polymeric material makes extraction of the drug from the dosage form more difficult. This feature could be beneficial in preventing or minimizing the misuse of dosage forms which contain drugs which are prone to abuse.

Abstract: In a method of manufacturing a skin care cream containing baked shell powder, highly calcium-containing shells such as dead shells or pearls is baked and crushed to fine powder to obtain baked shell powder. Then, the obtained baked shell powder is added to mix with a raw material for manufacturing cosmetic cream.

Abstract: An odor absorbing composition is provided comprising zinc salt of ricinoleic acid, a solubility promoter including sodium iminodisuccinate, water and optionally, other ingredients such as perfumes and antifungal agents or bactericides. The zinc ricinoleate can be completely solubilized in water, yet the solution will exhibit low foaming and friability. In addition, the end product may be in the form of a sprayable liquid, a thick liquid capable of clinging to a vertical surface, a gel or solid tablet, a powder, or any other form. The present invention further relates to a method for forming an odor absorbing composition comprising zinc salt of ricinoleate acid, sodium iminodisuccinate and water.