Patents Examined by Jill A. Warden
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Patent number: 11977091Abstract: An analyzer having an inner chassis surrounded by a housing includes sample and dilution probes, a mixing housing including first and second mixing chambers, a flow cytometer including a flow cell, and sample and sheath pumps configured to perform first and second pluralities of tasks, respectively. The first plurality of tasks includes: aspirating sample into the sample probe, dispensing sample from the sample probe into the first and second mixing chambers, delivering first sample-dilution fluid mixture to the flow cell, and delivering second sample-dilution fluid mixture to the flow cell. The second plurality of tasks includes: dispensing sheath to the flow cell in cooperation with the delivery of the first sample-dilution fluid mixture to the flow cell, and dispensing sheath to the flow cell in cooperation with the delivery of the second sample-dilution fluid mixture to the flow cell.Type: GrantFiled: July 9, 2021Date of Patent: May 7, 2024Assignee: IDEXX LABORATORIES INC.Inventors: Jonathan W. Lawrence, Mark R. Dumont, Jason J. Aguiar, John H. McGibbon, Nicholas P. Prince
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Patent number: 11977057Abstract: A method for characterizing a target peptide through a detection approach such as mass spectrometry is provided, including: introducing at least one guard molecule to mix with the target peptide; and applying the detection approach for the characterization of the target peptide. Each guard molecule is configured to have similar characteristics as the target peptide, yet is still distinguishable therefrom by the detection approach, such as having a mass spectrometry-distinguishable different M/z value compared with the target peptide. The method can be used to characterize a neoantigen peptide through mass spectrometry, upstream of which the method can further include steps for tissue sample preparation, HLA molecules enrichment, elution, clean-up, and purification. Some or all of these steps can be configured to be executed in a substantially automatic manner with little or no manual intervention. A system for implementing the neoantigen analysis method is further provided.Type: GrantFiled: June 13, 2021Date of Patent: May 7, 2024Assignee: COMPLETE OMICS INTERNATIONAL INC.Inventor: Qing Wang
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Patent number: 11975322Abstract: An optical positioning code disk, device and method for a microfluidic chip are provided. A cross section of an outer contour of the code disk is circular. N light transmissive openings are arranged uniformly around the code disk. The device includes: the code disk, a positioning pin, a rotating shaft, a motor, an internal photoelectric switch and an external photoelectric switch. A positioning surface is provided on the rotating shaft. The motor is fixedly connected with an end of the rotating shaft, and the other end of the rotating shaft passes through a center of the cross section of the code disk. The internal and external photoelectric switches are configured to identify the light transmissive openings on the code disk.Type: GrantFiled: October 26, 2020Date of Patent: May 7, 2024Assignee: CAPITALBIO TECHNOLOGY (CHENGDU) CO., LTD.Inventors: Chicheng Song, Guanbin Zhang, Yong Huang, Yong Tao, Ruoran Li, Hongcheng Zhou
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Patent number: 11977088Abstract: A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.Type: GrantFiled: June 16, 2017Date of Patent: May 7, 2024Assignee: Beckman Coulter, Inc.Inventors: Wido Menhardt, Matthew Hanson, Anthony Camisa
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Patent number: 11971426Abstract: An automatic analysis device that avoids carryover and prevents deterioration of analysis performance without controlling reaction cell position is provided with: a reaction cell in which a sample and a reagent are mixed and allowed to react; a light source that radiates light onto the mixed liquid of the sample and the reagent; a detector that detects the light radiated from the light source; and a cleaning mechanism that cleans the reaction cell. The cleaning mechanism includes an intake nozzle that draws in liquid from the reaction cell and a discharge nozzle that discharges the liquid into the reaction cell; the intake nozzle and the discharge nozzle can move vertically; and the intake nozzle is cleaned by lowering the intake nozzle into the reaction cell, in which a cleaning liquid or cleaning water have been accumulated, without drawing in the cleaning liquid or the cleaning water.Type: GrantFiled: January 23, 2019Date of Patent: April 30, 2024Assignee: Hitachi High-Tech CorporationInventors: Rei Konishi, Nobuhiko Sasaki, Masahiko Iijima
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Patent number: 11971421Abstract: A sample analysis system is available that can include a remote sampling system, at least one analyzer, and a controller. The remote sampling system can include a plurality of sample sources for providing a corresponding sample therefrom; and a plurality of sample collection devices selectively coupled to any of the plurality of sample sources for receiving at least one of the samples therefrom. The at least one analyzer can be coupled to the plurality of the sample collection devices for receiving at least one of the samples therefrom. The controller can be coupled with the remote sampling system and the at least one analyzer, the controller configured to control which of the sample sources is actively coupled to a given sample collection device at a given time.Type: GrantFiled: May 23, 2023Date of Patent: April 30, 2024Assignee: Elemental Scientific, Inc.Inventors: Tyler Yost, Jonathan Hein, Jae Seok Lee, Dong Cherl Park
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Patent number: 11970727Abstract: The present disclosure discloses a pathogenic microorganism sample collection and preservation device with a protection function, including a sampler and a preservation container; the sampler and the preservation container are both packaged by independent aseptic packaging bags. The sampler includes a sample collection mechanism, a holding mechanism, and a protection mechanism arranged between the sample collection mechanism and the holding mechanism. Before sample collection, the preservation container is sealed by an assorted sealing cover. The sample collection and preservation device of the present disclosure is convenient for holding and flexible adjustment of a sample collection angle. The protection mechanism between the holding mechanism and the sample collection mechanism plays a role of shielding, thus avoiding the problem of cross contamination.Type: GrantFiled: December 30, 2022Date of Patent: April 30, 2024Inventors: Yanhua Xie, Yansen Xie, Mitchell Brown
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Patent number: 11971423Abstract: An automatic analyzer is capable of transporting a sample at an optimum timing and a method of transporting the sample. An automatic analyzer includes an analysis unit which measures a sample, a transport unit which transports the sample to the analysis unit, and a control unit which controls the analysis unit and the transport unit. A sample is transported to the analysis unit by a time of starting an aspirating operation on the sample by allowing the analysis unit to perform a pre-measurement operation for each measuring method which needs to be performed before aspirating the sample even when the sample is still in the transport unit.Type: GrantFiled: May 16, 2019Date of Patent: April 30, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Naoto Suzuki, Masashi Akutsu, Akihiro Yasui
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Patent number: 11965867Abstract: A sensing element for a chemiresistor sensor and a method of making such a sensing element is disclosed. The sensing element may include: one or more first type of 3D elements, each comprising a first type of chemiresistor particles; and one or more second type of 3D elements, each comprising a second type of chemiresistor particles. At least one of the one or more first type of 3D elements and at least one of the one or more second type of 3D elements may have one or more joint surface. The first type of chemiresistor particles may differ from the second type of chemiresistor particles by at least one of: a type of nanoparticle core and a type of organic ligands bonded to each nanoparticle core.Type: GrantFiled: May 28, 2019Date of Patent: April 23, 2024Assignee: NanoScent Ltd.Inventor: Yair Paska
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Patent number: 11965898Abstract: An automatic nucleic acid detection system and a method thereof are disclosed. The automatic nucleic acid detection method includes: performing, by an automatic control subsystem, on a nucleic acid extraction machine platform, a nucleic acid extraction on one or more specimens in a sample tray to generate one or more corresponding nucleic acids in the sample tray; distributing, by the automatic control subsystem, on a nucleic acid distribution machine platform, the nucleic acid in each hole of the sample tray and a first reagent into a plurality of holes of a detection tray, wherein the number of holes of the detection tray is greater than that of the sample tray; and performing, by the automatic control subsystem, on a nucleic acid detection machine platform, a nucleic acid detection on the detection tray.Type: GrantFiled: July 23, 2020Date of Patent: April 23, 2024Assignees: TCI GENE INC, TCI CO., LTDInventors: Yung-Hsiang Lin, Cheng-Hong Hsieh, Ciao-Ting Chen, Tsung-Cheng Chen
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Patent number: 11959844Abstract: There is provided a cool box for use in an automatic analyzer. The cool box has a box body and an air circulator. The box body has a receiving space capable of accommodating therein receptacles for analytes or reagents. The circulator has an intake portion, a fan, and an exhaust portion and operates to circulate air in the receiving space by rotation of the fan. The circulator further includes an inhibitor removing agent retaining portion on which a pouch is set. The pouch contains an analysis inhibitor removing agent for removing components (analysis inhibitor) which adversely affect or inhibit analysis of the analytes.Type: GrantFiled: July 30, 2021Date of Patent: April 16, 2024Assignee: JEOL Ltd.Inventors: Takashi Yaginuma, Kiyohiro Ishikawa, Yusuke Yamanaka
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Patent number: 11959929Abstract: A method of measuring and identifying LSD and its major metabolite O-H-LSD, by obtaining a sample from an individual, and measuring, identifying, and quantifying LSD and O-H-LSD in the sample by performing a LC-MS/MS analysis. A method of treating and monitoring individuals taking LSD, by administering a microdose of LSD, a prodrug of LSD, or an analog of LSD to the individual, monitoring the individual by obtaining a sample from an individual and measuring and identifying the analytes in the sample by performing a LC-MS/MS analysis, and adjusting the microdose based on the amount of LSD quantified in the LC-MS/MS analysis. A method of adjusting dosing of LSD, by administering a microdose of LSD, a prodrug of LSD, or an analog of LSD to the individual, and adjusting the microdose based on blood concentration analytics.Type: GrantFiled: October 20, 2021Date of Patent: April 16, 2024Assignee: Universitätsspital BaselInventors: Matthias E. Liechti, Urs Philipp Duthaler
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Patent number: 11946930Abstract: A device for use in the detection of binding affinities comprises a substrate, a planar waveguide arranged thereon and having an outer surface. The device further comprises a grating for coupling coherent light of a predetermined wavelength into the planar waveguide such that the coherent light coupled into the planar waveguide propagates through the planar waveguide in a predetermined propagation direction. An evanescent field of the coherent light propagates along the outer surface of the planar waveguide. The outer surface of the planar waveguide has receptor molecules arranged thereon capable of binding target samples to the receptor molecules such that light of the evanescent field is diffracted by the target samples bound to the receptor molecules. The receptor molecules are arranged along a plurality of straight parallel lines such that a portion of the light of the evanescent field is diffracted by the target samples bound to the receptor molecules.Type: GrantFiled: February 28, 2019Date of Patent: April 2, 2024Assignee: HOFFMANN-LA ROCHE INC.Inventor: Christof Fattinger
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Patent number: 11940403Abstract: A device for the detection of a food allergen includes a sensor having a printed circuit board and a chip comprising a molecularly imprinted polymer (MIP) and a non-imprinted polymer (NIP); a reservoir comprising a liquid; and a chamber for mixing the liquid with a food.Type: GrantFiled: May 1, 2018Date of Patent: March 26, 2024Assignee: Amulet, Inc.Inventors: Srikanth Rao Agnihotra, Madanodaya Sundhoro, Brent Amberger, Abigail Barnes, Joseph Belbruno, Seung Hyuk Noh, Jeanette Numbers, Elizabeth Soucy
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Patent number: 11938482Abstract: A vial cap for a sample vial includes a cylindrical cap body defining a first circular opening at a first end. The vial cap also includes a cap lid extending radially inward from a second end of the cylindrical cap body. The cap lid defines a second circular opening. The vial cap also includes a septum located within the cylindrical cap body and in contact with the cap lid. The septum spans the second circular opening defined by the cap lid portion. The vial cap also includes a number of flexible threads extending from an internal surface of the cylindrical cap body.Type: GrantFiled: June 1, 2021Date of Patent: March 26, 2024Assignee: Waters Technologies CorporationInventor: Moon Chul Jung
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Patent number: 11940455Abstract: A consumable management system comprising a consumable storage cluster with a plurality of storage compartments is presented. Each storage compartment is configured to receive one or more consumables. The consumable management system further comprises storage compartment indicators to provide guidance to a user and a detection unit for validating user action(s).Type: GrantFiled: September 10, 2019Date of Patent: March 26, 2024Assignee: Roche Diagnostics Operations, Inc.Inventors: Urs Suter, Riccardo Leone Benedetti, Gregor Hotz, Oliver Rusterholz, Robert Theiler
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Patent number: 11940457Abstract: A robotic arm of an automated pipetting system has a pipetting tip adapter and a slide switch to detect the presence of pipetting tips on the pipetting tip adapter is disclosed. The slide switch has first support member and second support member configured to slide relative to one another between first and second positions along a movement axis, an electrically conducting contact pad arranged on the first support member, an electrically conducting terminal physically attached to second support member in physical contact with the contact pad when support members are in first position, where the terminal is a first resilient wiping member expanding along the movement axis, first wiping member is not in physical contact with the contact pad when support members are in second position, and an electric current can flow between first wiping member and the contact pad when support members are in first position.Type: GrantFiled: November 11, 2021Date of Patent: March 26, 2024Assignee: TECAN TRADING AGInventor: Thomas Geiges
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Patent number: 11940429Abstract: A method is provided for authenticating a botanical. The method includes identifying at least one marker compound of the botanical. A sample comprising the botanical is injected into a chromatography system that includes a mobile phase delivery module, an autosampler, a chromatography column, a chromatography column manager, and at least one detector. The method also includes extracting a chromatogram of the at least one marker compound and extracting a spectrum at a chromatographic peak retention time of the at least one marker compound. The method also includes quantifying at least one peak of the extracted chromatogram and quantifying at least one band of the extracted spectrum. The quantified at least one peak of the extracted chromatogram and the quantified at least one band of the extracted spectrum are compared to a set of authentication criteria to determine authenticity of the botanical.Type: GrantFiled: May 1, 2019Date of Patent: March 26, 2024Assignee: Waters Technologies CorporationInventors: Jinchuan Yang, Paul Rainville
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Patent number: 11931735Abstract: Methods and apparatus for manufacturing a microfluidic arrangement are disclosed. In one arrangement, a continuous body of a first liquid is provided in direct contact with a first substrate. A second liquid covers the first liquid. A separation fluid, immiscible with the first liquid, is propelled through at least the first liquid and into contact with the first substrate along all of a selected path on the surface of the first substrate. First liquid that was initially in contact with all of the selected path is displaced away from the selected path. The first liquid is divided to form sub-bodies of first liquid that are separated from each other. For each of one or more of the sub-bodies, a sub-body footprint represents an area of contact between the sub-body and the first substrate, and all of a boundary of the sub-body footprint is in contact with a closed loop of the selected path surrounding the sub-body footprint.Type: GrantFiled: February 5, 2019Date of Patent: March 19, 2024Assignee: Oxford University Innovation LimitedInventors: Edmond Walsh, Alexander Feuerborn, Peter Richard Cook, Cristian Soitu
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Patent number: 11931741Abstract: Micro-valve system includes two or more superimposed tubes and a pressing device for fluid control in miniaturized capillary connections. The micro-valve system and method of fabrication can be tailored to the requirements of a wide range of applications; composition, sturdiness and thickness of plastic tubes; and capable of been adapted to the resilient of mechanical pressure and the passing and transport of fluid types.Type: GrantFiled: May 11, 2021Date of Patent: March 19, 2024Assignee: Princeton Biochemicals, IncInventors: Norberto Guzman, Daniel E. Guzman