Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, pro-drugs, precursors thereof, and/or salts thereof, are described.
Type:
Grant
Filed:
February 20, 2009
Date of Patent:
February 4, 2014
Assignee:
Royal Institution for the Advancement of Learning/McGill University
Inventors:
Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
Abstract: The invention relates to a new prescription of NAC in the treatment of endometriosis and of indications associated with endometriosis, in a human or mammalian animal patient. In addition an effective dose regimen of NAC in the treatment of endometriosis is proposed. In one embodiment of the present invention the prescribed treatment regimen may be used e.g. in order to control the frequency and the intensity of pain symptoms (dysmenorrhea, dyspareunia and acyclic chronic pelvic pain), to reduce the size of endometriotic lesions eventually up to their disappearance, to reduce recurrences after surgery and/or to improve fertility. Side effects of this treatment are virtually absent and, in particular, this treatment does not hinder pregnancy.
Type:
Grant
Filed:
March 23, 2012
Date of Patent:
January 28, 2014
Assignee:
Iasomai AB
Inventors:
Tiziana Parasassi, Maria Grazia Porpora
Abstract: Methods for restoring a more nearly normal joint function in an osteoarthritic dog and methods for decreasing the likelihood of a dog developing osteoarthritis involve administering to the dogs a composition containing an effective concentration of the omega-3 fatty acid, eicosapentaenoic acid (EPA).
Type:
Grant
Filed:
August 6, 2004
Date of Patent:
January 21, 2014
Assignee:
Hill's Pet Nutrition, Inc.
Inventors:
Dale A Fritsch, Dennis E Jewell, William D Schoenherr
Abstract: A method for modulating enzymatic degradation of articular cartilage in a dog comprises administering to the dog an enzymatic degradation modulating effective amount of eicosapentaenoic acid (EPA), for example as a component of a food composition. By practice of the method in a dog having arthritis, mobility of the dog can be increased, weight bearing in an arthritic limb can be increased, and/or pain associated with arthritis can be reduced.
Type:
Grant
Filed:
February 14, 2005
Date of Patent:
January 21, 2014
Assignee:
Hill's Pet Nutrition, Inc.
Inventors:
Bruce Caterson, Christopher Bond Little, John Leander Harwood, John Francis Innes, Dale A. Fritsch, Dennis Edward Jewell, William David Schoenherr
Abstract: A method for modulating enzymatic degradation of articular cartilage in a dog comprises administering to the dog an enzymatic degradation modulating effective amount of eicosapentaenoic acid (EPA), for example as a component of a food composition. By practice of the method in a dog having arthritis, mobility of the dog can be increased, weight bearing in an arthritic limb can be increased, and/or pain associated with arthritis can be reduced.
Type:
Grant
Filed:
June 22, 2010
Date of Patent:
January 14, 2014
Assignee:
Hill's Pet Nutrition, Inc.
Inventors:
Bruce Caterson, Christopher Bond Little, John L. Harwood, John Francis Innes, Dale A. Fritsch, Dennis Edward Jewell, William David Schoenherr
Abstract: A method for modulating enzymatic degradation of articular cartilage in a dog comprises administering to the dog an enzymatic degradation modulating effective amount of eicosapentaenoic acid (EPA), for example as a component of a food composition. By practice of the method in a dog having arthritis, mobility of the dog can be increased, weight bearing in an arthritic limb can be increased, and/or pain associated with arthritis can be reduced.
Type:
Grant
Filed:
June 22, 2010
Date of Patent:
January 14, 2014
Assignee:
Hill's Pet Nutrition, Inc.
Inventors:
Bruce Caterson, Christopher Bond Little, John L. Harwood, John Francis Innes, Dale A. Fritsch, Dennis Edward Jewell, William David Schoenherr
Abstract: A synergistic combination of a vanilloid receptor VR-1 antagonist and an NSAID or a pharmaceutically acceptable salt or solvate of either or both compounds thereof.
Type:
Grant
Filed:
July 16, 2008
Date of Patent:
December 31, 2013
Assignee:
Novartis AG
Inventors:
Alyson Fox, Mark Nash, Bindi Sohal, Elliot Lilley
Abstract: Compositions having a mixture of lidocaine, prilocaine and tetracaine, or their pharmaceutically acceptable salts. A preferred composition includes the following components in the indicated approximate w/w percentages: 1.5% lidocaine base; 1.5% prilocaine base; 4% tetracaine base and water. In some implementations, also included may be about 10% methylpynrolidone; 2% dimethyl sulfoxide; 0.08% topical hyaluronidase; 1.5% guar gum; 1% polyoxyethylenesorbitan monolaurate; 0.5 polyoxyethylenesorbitan monooleate, and water to 100%. Such compositions exhibits a high concentration on skin, a deep anesthetic effect and a significantly more rapid onset of the anesthetic effect than comparable transdermal anesthetics.
Abstract: The present invention relates to a solid cosmetic composition comprising, as a structure agent, a combination consisting of a saturated straight-chain polymer and an agglutinating agent for this polymer. The composition of the invention has a rigid, moldable and stable structure, being suitable for application as, for example, lipstick, blush, eye shadow, stick base, lip protectors (either colorful or colorless), deodorants, perfumes, among others.
Abstract: A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.
Type:
Grant
Filed:
November 13, 2007
Date of Patent:
November 26, 2013
Assignees:
Oregon Health & Science University, The United States of America, as represented by the Department of Veterans Affairs
Inventors:
Michael K. Riscoe, Rolf Winter, Jane X. Kelly, David J. Hinrichs, Martin J. Smilkstein
Abstract: Orally disintegrating film dosage forms for delivering active pharmaceutical agents, methods of formulating the dosage forms to retard absorption through the oral mucosa, and methods of using the dosage forms for the treatment of various medical conditions are provided.
Type:
Grant
Filed:
October 2, 2007
Date of Patent:
November 12, 2013
Assignees:
Labtec GmbH, APR Applied Pharma Research S.A.
Inventors:
Christian Leichs, Armin Breitenbach, Ingo Lehrke, Paolo Galfetti
Abstract: A dosage form for hormonal contraception containing a given number of hormone-containing daily units and a given number of hormone-free daily units for daily, oral administration, where the hormone-containing daily units each contain at most the minimum effective daily amount of folic acid for women and the hormone-free daily units contain at least a multiple of this amount up to the maximum permissible amount of folic acid for women.
Abstract: The present invention provides a method for preventing or ameliorating skin psoriasis by applying as an active ingredient, a compound represented by general formula (I) or a salt thereof: (wherein R1, R2, and R3 simultaneously or separately represent a lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, or phenyl group, or a hydrogen atom).
Abstract: The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.
Type:
Grant
Filed:
October 15, 2010
Date of Patent:
October 29, 2013
Assignee:
Laboratorios del Dr. Esteve, S.A.
Inventors:
Enrique Portillo Salido, Sebastia Videla Ces
Abstract: Dermatological compositions containing, in a physiologically acceptable medium, at least one retinoid, dispersed benzoyl peroxide and at least one gelling agent of the family of the carrageenans, are useful for treating dermatological conditions and afflictions linked to disorders of cell differentiation and/or proliferation and/or keratinization, notably for treating acne vulgaris.
Abstract: The invention relates to methods for treating burns or inflammation utilizing beneficial pharmaceutical compositions comprising diclofenac sodium salt in unusually low amounts. The compositions represent opaque emulsion-gels, in which diclofenac is kept fully dissolved.
Abstract: The invention relates to new 3?-, 7-substituted-indirubins of formula (I) wherein R represents N—OH, N—O-alkyl or N—O—CO-alkyl, NO—(Ra)n1-Het, N—O—(Y)n1—N Ra Rb, N—O—CO—N(Rb Rc), radical with Het representing an aliphatic nitrogeneous heterocycle, Y being an optionally substituted —CH2— radical, n1 being 1 to 3, and X is an halogen atom selected in the group comprising F, Cl, Br, I, and Z is H or CH3 and the salts thereof.
Type:
Grant
Filed:
December 21, 2006
Date of Patent:
October 8, 2013
Assignees:
Centre National de la Recherche Scientifique, University of Pierre and Marie Curie (Paris 6), University of Rennes 1, University of Lleida, Universite d'Athenes
Abstract: A sterile composition of a pharmaceutical compound is prepared by combining solvent with a non-sterile pharmaceutical compound to form a solution and filtering to yield a sterile pharmaceutical compound, optionally removing all or part of the solvent, and under sterile conditions combining the compound with a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
February 19, 2003
Date of Patent:
September 24, 2013
Assignee:
Resolution Chemicals Limited
Inventors:
Parveen Bhatarah, Kenneth Alan Greenwood
Abstract: Provided is a resin powder for a dermatologic composition composed of resin particles having an average volume particle size of 2.0 to 20.0 ?m, a shape factor SF1 of 110 to 140 and an average volume particle size distribution GSDv of 1.3 or less. Also disclosed are a skin cleansing composition and a cosmetic composition containing the resin powder, and a preparation process of the resin powder.
Abstract: The invention relates to novel combinations based on anticholinergics, ?2-adrenoceptor agonists, PDE 4 Inhibitors, glucocorticoids, and leukotriene-receptor antagonists, process for their production and their use for the treatment of inflammatory diseases, preferably respiratory diseases as bronchial asthma and chronic obstructive pulmonary diseases (COPD) or rheumatic or autoimmune diseases.
Type:
Grant
Filed:
September 23, 2011
Date of Patent:
August 27, 2013
Inventors:
Joachim Maus, Kastrup Horst, Istvan Szelenyi, Peter Jurgen Cnota, Bauhofer Artur