Patents Examined by John D. Peabody, III
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Patent number: 5650543Abstract: This invention relates to ethoxylated acetylenic glycol compositions represented by the formula: ##STR1## wherein m and n are integers and the sum is from 4-12. These ethoxylated acetylenic diols are excellent as surfactants alone or admixed with other surfactants for use in water borne coatings.Type: GrantFiled: August 31, 1995Date of Patent: July 22, 1997Assignee: Air Products and Chemicals, Inc.Inventor: Steven Wayne Medina
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Patent number: 5650431Abstract: A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, ##STR1## wherein A, B, X, Y, and Z are defined in the specification.Type: GrantFiled: May 13, 1996Date of Patent: July 22, 1997Assignee: AllerganInventors: Robert M. Burk, Achim H. Krauss, David F. Woodward
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Patent number: 5629409Abstract: Disazo dyes of the formula ##STR1## where n is 0, 1 or 2,D is a radical of a diazo component which is free of fiber-reactive groups,R.sup.1, R.sup.2 and R.sup.3 are each hydrogen or unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl,Z is chlorine or unsubstituted or substituted amino andQ is hydroxysulfonylphenylene,are used for printing cellulose-containing materials.Type: GrantFiled: March 10, 1995Date of Patent: May 13, 1997Assignee: BASF AktiengesellschaftInventors: Hermann L offler, Manfred Patsch
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Patent number: 5616740Abstract: Process of making compounds having the formula ##STR1## wherein --OR.sup.1 comprises alkanoyl or the C-13 side-chain of taxol; R.sup.2, R.sup.3, and R.sup.6 can be oxygenated or hydrogen in various combinations; and R.sup.4 and R.sup.5 are acyl groups.Type: GrantFiled: May 11, 1995Date of Patent: April 1, 1997Assignee: Abbott LaboratoriesInventors: Larry L. Klein, Clinton M. Yeung, Leping Li
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Patent number: 5536734Abstract: Crop protection agents contain dihydropyrans of the formula ##STR1## wherein the variable substituents are defined in the specification.Type: GrantFiled: June 21, 1994Date of Patent: July 16, 1996Assignee: BASF AktiengesellschaftInventors: Bernd Mueller, Siegbert Brand, Hubert Sauter, Franz Roehl, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5403960Abstract: A process for preparing, in high yield, a sulfurized olefinic product for use in lubricating oil compositions having a chlorine content of less than about 1000 ppm, a sulfur content of from about 40 to about 50 weight percent and a viscosity at 100.degree. C. of within the range of from about 5 to about 15 cSt.Type: GrantFiled: September 23, 1993Date of Patent: April 4, 1995Assignee: Ethyl Petroleum Additives, Inc.Inventors: Abbas Kadkhodayan, Paul G. Griffin
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Patent number: 5391801Abstract: A hydroformylation process for preparing a hydroformylated product by reacting an olefinic compound with hydrogen and carbon monoxide in the presence of a Group VIII metal catalyst, in the reaction of which there is present a phosphite compound having the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 are respectively an aromatic hydrocarbon groups which may be the same or different and the aromatic hydrocarbon group has at least a hydrocarbon group on a carbon atom adjacent to a carbon atom bonded with an oxygen atom as a substituent; A.sup.1 is an n-valent organic group having an aliphatic hydrocarbon group, a cycloaliphatic hydrocarbon group or an aromatic hydrocarbon group bonded with an adjacent oxygen atom, which may respectively have a substituent; n is an integer of from 2 to 4; and the respective [--O--P(OR.sup.1)(OR.sup.2)] group may be the same or different.Type: GrantFiled: April 16, 1993Date of Patent: February 21, 1995Assignee: Mitsubishi Kasei CorporationInventors: Keiichi Sato, Yuji Kawaragi, Masaki Takai, Tooru Ookoshi
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Patent number: 5310953Abstract: The substituted pentaalkylchromans of the general formula: ##STR1## wherein R denotes a lower alkyl group having 1 to 4 C atoms and Hal denotes chlorine, bromine or iodine, are novel intermediates for the preparation of hypolipidaemic pharmaceuticals. A process for their preparation is described in which a trialkylhydroquinone is reacted with a halogenated butenol to give a substituted tetraalkylhydroquinone, which is finally cyclized to the final product.Type: GrantFiled: March 5, 1993Date of Patent: May 10, 1994Assignees: Lonza Ltd., Sankyo Company Ltd.Inventor: David Laffan
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Patent number: 5302600Abstract: This invention provides a compound of formula I, ##STR1## and 27-substituted derivatives thereof which are useful as immunosuppressive, anti-inflammatory, antifungal, antitumor, and antiproliferative agents. The compound depicted by formula I is named 27-hydroxyrapamycin, and may also be referred to as 27-deoxo-27-hydroxyrapamycin.Type: GrantFiled: July 22, 1993Date of Patent: April 12, 1994Assignee: American Home Products CorporationInventor: Frances C. Nelson
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Patent number: 5254674Abstract: A diaminoazothiophene compound represented by the formula (I): ##STR1## salts thereof or metal complexes thereof and a method for preparing the same.Type: GrantFiled: November 6, 1992Date of Patent: October 19, 1993Assignee: Osaka Gas Company, LimitedInventors: Yasunori Yokomichi, Shinichi Tada, Hitoshi Nishino, Kenji Seki
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Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
Patent number: 5210235Abstract: A method of making compounds of the formulae: ##STR1## wherein X is ##STR2## R.sup.1 is hydrogen, methyl, C.sub.1-10 alkoxycarbonyl or arylsulfonyl when X is CH.sub.3 CH.sub.2 CHNH.sub.2 and is additionally aralkoxycarbonyl when X is NH.sub.2 ; one of R.sup.2 and R.sup.3 is hydrogen and the other is OH, NHR.sup.1 or NMeR.sup.1 where R.sup.1 is as defined above; R.sup.4 is hydrogen or C.sub.1-10 alkyl when X is CH.sub.3 CH.sub.2 CHNH.sub.2 and is additionally aralkyl when X is NH.sub.2 ; R.sup.5 is hydrogen or C.sub.1-3 alkyl when X is CH.sub.3 CH.sub.2 CHNH.sub.2 ; R.sup.5 is hydrogen when X is NH.sub.2 ; one of R6 and R7 is hydrogen and the other is methyl except when X is CH.sub.3 CH.sub.2 CHNH.sub.2 and R.sup.2 is H, in which case R.sup.6 is methyl and R.sup.7 is hydrogen. These compounds are made from erythromycin-derived fragments of the formulae: ##STR3## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined as before for when X is NH.sub.2 ; R.sup.5 is hydrogen or C.sub.1-3 alkyl; if R.sup.Type: GrantFiled: August 26, 1992Date of Patent: May 11, 1993Assignee: Merck & Co., Inc.Inventors: Sherman T. Waddell, Timothy A. Blizzard -
Patent number: 5208381Abstract: Phosphonium salts of the formula ##STR1## wherein A signifies aryl and Y.sup.- signifies C.sub.1 -C.sub.6 -alkanoate or hydroxytrifluoroborate, as well as their manufacture from 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol with a triarylphosphine and with a C.sub.1 -C.sub.6 -alkanoic acid or a boron trifluoride etherate and, if desired after conversion into the phosphonium salt of a strong acid, further reaction to give lycopene.Type: GrantFiled: June 29, 1992Date of Patent: May 4, 1993Assignee: Hoffmann-La Roche Inc.Inventor: Karl Meyer
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Patent number: 5200431Abstract: Method for separating 1,1,1,2-tetrafluoroethane from a mixture thereof with chlorine-containing halogenated hydrocarbons such as HCFC's 1122, 124, 114, 114a and 133a which comprises adding an extraction agent to the mixture and extractively distilling the mixture in an extractive distillation zone from which HFA 134a containing less than 10 ppm of chlorinated contaminants is recovered. Suitable extraction agents include trichloroethylene, perchloroethylene, alpha-pinene and cyclohexane.Type: GrantFiled: August 21, 1991Date of Patent: April 6, 1993Assignee: Imperial Chemical Industries PLCInventors: Pravin K. Dattani, John D. Scott, Barry W. Farrant, Charles J. Shields
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Patent number: 5192769Abstract: Disclosed is a pyrazolonaphthyridine compound represented by the formula: ##STR1## wherein R.sup.1 is represents hydrogen, lower alkyl, aralkyl, or substituted or unsubstituted aryl, R.sup.2 represents hydrogen, lower alkyl, thienyl, substituted or unsubstituted aryl, hydroxy or amino, or a pharmaceutically acceptable salt thereof.The compound possesses antiinflammatory effect, immunosuppressive effect, broncho-dilatory effect and hair growth-stimulative effect.Type: GrantFiled: July 30, 1992Date of Patent: March 9, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Takashi Kawakita, Takeshi Kuroda, Kenji Ohmori, Hiroshi Nakajima, Toshikazu Kamiya, Tatsuya Tamaoki
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Patent number: 5175381Abstract: A method for recovering halogenated hydrocarbons (FCH) from synthetic foams wherein halogenated hydrocarbons (FCH) are released from synthetic foam in a hermetically sealed processing chamber and transferred to a gaseous carrier medium of steam. The steam/FCH mixture is removed from the processing chamber and subjected to condensation to remove pure FCH from the condensed water.Type: GrantFiled: July 29, 1991Date of Patent: December 29, 1992Assignee: SMG Sommer Metallwerke GmbHInventors: Heinz Hoberg, Joachim Christiani, Martin Bender
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Patent number: 5175314Abstract: This invention relates to certain herbicidal oxatricyclic ethers, agriculturally suitable compositions thereof and a method for their use as broad spectrum preemergent or postemergent herbicides.Type: GrantFiled: January 8, 1992Date of Patent: December 29, 1992Assignee: E. I. Du Pont de Nemours and CompanyInventor: Wendy S. Taylor
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Patent number: 5166452Abstract: A process for inhibiting and destroying peroxides in dialkyl ethers having the general formula R.sub.1 OR.sub.2 in which R.sub.1 and R.sub.2 are alkyl groups having 1 to 6 carbon atoms, which comprises adding, as inhibitor, a quaternary alkyl iodide of the general formula[CH.sub.3 alk.sub.3 P]Ito the dialkyl ethers.Type: GrantFiled: September 6, 1991Date of Patent: November 24, 1992Assignee: Hoechst AktiengesellschaftInventors: Reinhard Gradl, Heinz Erpenbach, Norbert Weferling, Erhard Jagers
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Patent number: 5162511Abstract: Sulfonic acids are reacted with sodium nitrite to form new compositions specifically nitrosyl sulfonates. The nitrosyl sulfonates are useful in reacting with a dye base to form a diazo composition which can in turn react with a coupling agent to form a diazo dye. The nitrosyl sulfonate can also be used to react with an aromatic composition to nitrosoate an aromatic composition. These reactions are particularly useful in the formation of a dispersed dye because the dye can be formed directly in a nonpolar organic solvent and can be used without purification of the dye product. Particularly useful is the nitrosyl dodecyl benzene sulfonate since the formed product is soluble in nonpolar solvents and all reaction products remain in solution and aid with the dyeing of fabrics.Type: GrantFiled: March 27, 1992Date of Patent: November 10, 1992Inventor: Rodger L. Gamblin
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Patent number: 5162585Abstract: A process for preparing a dihydroxy bis-sulfide is disclosed, wherein a thiolate salt, a dihaloalkane, an ether solvent that is partially soluble in water and is substantially nonreactive with either said thiolate salt or said dehaloalkane; and water are contacted under reaction conditions sufficient to synthesize a dihydroxy bis-sulfide; to subsequently recover a dihydroxy bis-sulfide.Type: GrantFiled: April 8, 1991Date of Patent: November 10, 1992Assignee: Phillips Petroleum CompanyInventor: James E. Shaw
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Patent number: 5157134Abstract: Dihydroxyheptonic acids containing an oxabicycloheptane nucleus are provided which have the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## and X, R.sub.1, R.sub.2 and R.sub.3 are as defined herein.Type: GrantFiled: March 12, 1992Date of Patent: October 20, 1992Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky