Abstract: GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.
Type:
Grant
Filed:
September 25, 1996
Date of Patent:
April 21, 1998
Assignee:
Immusol, Incorporated
Inventors:
Markley C. Leavitt, Richard Tritz, Elizabeth Duarte, Jack Barber, Mang Yu