Abstract: A novel retrovirus isolated from human lymphoma cells is disclosed. The retrovirus is characterized by a C-type retroviral particle of approximately 100 nm diameter; and an approximately 27,000 molecular weight p24 core protein. Also disclosed are cell lines from which the virus can be obtained and screening methods for detecting the presence of the virus in human sera.
Type:
Grant
Filed:
June 5, 1989
Date of Patent:
April 28, 1992
Assignees:
Regents of the University of California, Genelabs Incorporated
Inventors:
Valerie L. Ng, Michael S. McGrath, Gregory R. Reyes
Abstract: A new strain of Human Immunodeficiency Virus (HIV), which is the major etiological agent of Acquired Immune Deficiency Syndrome (AIDS), is identified. The new strain, products derived from the new strain, a diagnostic method for detecting antibodies to the strain in biological fluids, and a diagnostic kit for carrying out the method are described.
Type:
Grant
Filed:
October 28, 1987
Date of Patent:
May 28, 1991
Assignee:
Institut Pasteur
Inventors:
Simon Wain-Hobson, Thierry Huet, Eric Delaporte, Francoise Brun-Vezinet
Abstract: New transcriptional regulatory sequences useful in the expression of pro- or eukaryotic proteins in eukaryotic organisms are provided comprising the 5' flanking region of the vaccinia virus late 11 kDa gene. Also described are recombinant vectors and recombinant infectious poxviruses containing such transcriptional regulatory sequences operatively linked to foreign genes, and live vaccines based upon these recombinant infectious poxviruses.
Type:
Grant
Filed:
March 27, 1986
Date of Patent:
May 21, 1991
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Hendrik G. Stunnenberg, Riccardo Wittek