Patents Examined by Jon Weber
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Patent number: 7618805Abstract: A gamma-sterilizable nutrient medium based on casein soya peptone agar for the detection of microorganisms in hydrogen peroxide-bearing air or on hydrogen peroxide-bearing surfaces, with a content of between 2 and 10% by weight of sodium thioglycolate, between 5 and 20% by weight of sodium thiosulfate and between 10 and 30% by weight of sodium disulfite in each case with respect to the agar. Preferably the agar used is microbial content test agar and the nutrient medium may contain between 0.1 and 0.25% by weight of sodium pyruvate with respect to the agar. If bromocresol purple and bromocresol violet are used as pH-indicators the nutrient medium may also contain polyvinylpyrrolidone.Type: GrantFiled: July 18, 2003Date of Patent: November 17, 2009Inventor: Jürgen Horn
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Patent number: 7595147Abstract: The invention provides methods to identify moieties which specifically bind the flap-tip helix of the ? subunit of RNA polymerase and to identify inhibitors of the interaction between those moieties and the flap-tip helix.Type: GrantFiled: April 23, 2002Date of Patent: September 29, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Robert C. Landick, Katherine M. Geszvain, Irina E. Artsimovitch, Innokenti I. Toulokhonov, Rachel A. Mooney
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Patent number: 7582415Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.Type: GrantFiled: September 6, 2002Date of Patent: September 1, 2009Inventor: Don Straus
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Patent number: 7541037Abstract: The present invention provides a coating agent, wherein an oxygen-barrier property enhancer, which is one or more of glucose, mannose, maltose, trehalose, fructose, raffinose, arabinose, nigerooligosaccharide, lactose, D-glucono-1,5-lactone, arginine hydrochloride, ferrous sulfate, sodium dihydrogen phosphate, mannitol, Palatinit, and vitamin C, is added to acid-treated yeast cell wall fractions consisting of cell residue obtained by removing the internal soluble cell components of enzyme-treated yeast, the residue being treated with an acidic aqueous solution to further remove the solubilized components, and which enables a film being formed by coating with the coating agents for an oxygen permeability test by using the coating agent to attain at 23° C. and relative humidity of 60% an oxygen permeability coefficient of<0.1 cm3 mm/m2atm 24 hr.Type: GrantFiled: December 18, 2001Date of Patent: June 2, 2009Assignee: Kirin Beer Kabushiki KaishaInventors: Takahide Kasai, Takahiro Eguchi
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Patent number: 7521203Abstract: Embodiments of the present invention generally relate to novel fed-batch fermentations wherein processes of DO-stat and pH-stat are combined for nutrient feeding control.Type: GrantFiled: May 6, 2005Date of Patent: April 21, 2009Assignee: N.V. OrganonInventors: WengLong Roy Lin, Firoz Rustom Mistry, Arun Narayanaswamy Tholudur, Edward Todd Sorensen, Wan-Seop Kim, Dana Perrin
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Patent number: 7494796Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.Type: GrantFiled: October 13, 2004Date of Patent: February 24, 2009Assignee: The Scripps Research InstituteInventors: Lital Alfonta, Peter G. Schultz, Zhiwen Zhang
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Patent number: 7485305Abstract: The present invention relates to a novel allergen from house-dust mites, to polypeptides derived from said allergen and polynucleotides encoding the same. Furthermore, the invention provides antibodies directed against the allergen and to the use of the polypeptides, polynucleotides and/or antibodies in therapy and diagnosis of allergic disorders.Type: GrantFiled: June 1, 2005Date of Patent: February 3, 2009Assignee: Biomay AGInventors: Rudolf Valenta, Peter Valent, Margit Weghofer, Susanne Vrtala, Maria-Theresia Krauth
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Patent number: 7482433Abstract: Interleukin-5 receptor (IL-5R) ligands comprising amino sequences of formula TGGGDGYVX3VEX4ARCPTCK, EGYVX3VEX4ARCPTCK, EGYVX3VEX4ARCPTCR, GYVX3VEX4ARCPTCG, EGYVX3VEX4ARCPTCG, GYVX3VEX4ARCPTCR, and EGYVX3VEX4AACPTCR, and methods of using the same, are described and claimed.Type: GrantFiled: May 2, 2006Date of Patent: January 27, 2009Assignee: Affymax, Inc.Inventors: Palani Balu, Qun Yin, Bruce England
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Patent number: 7479481Abstract: Compositions and methods for treating ocular diseases and disorders are provided. The composition can contain at least one lantibiotic, which can be administered topically by injection, systemically, or by other appropriate means. The methods provided include the administration of a therapeutically effective amount of a formulation containing at least one lantibiotic to the appropriate section of the eye.Type: GrantFiled: May 6, 2005Date of Patent: January 20, 2009Assignee: Molichem Medicines, Inc.Inventor: Luis Molina
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Patent number: 7465855Abstract: A grass with improved environmental stress tolerance and low animal toxicity is disclosed where the grass is infected with an isolated endophyte selected from the groups consisting of USDA-PI no. 269850, Ijoukak, Morocco 92060, Boumalne-de-Dades, Morocco KBG 5921, USDA-PI no. 516560, Oujda, Morocco KBG 5892, and mixtures and combinations thereof. A method for stably infecting the grasses is also disclosed.Type: GrantFiled: February 28, 2005Date of Patent: December 16, 2008Assignee: The Board of Trustees of the University of ArkansasInventors: Charles P. West, Edgar L. Piper
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Patent number: 7449327Abstract: An improved system and method for dispensing dehydrated culture media (DCM) powder into containers for preparation as a culture media. The manual and automated systems and methods operate to dispense DCM powder, as well as liquid, into vessels or media preparation instruments in a manner to avoid DCM dust inhalation by persons in the surrounding area and contamination of equipment and surfaces in the surrounding area.Type: GrantFiled: May 3, 2005Date of Patent: November 11, 2008Assignee: Mediatek, LLCInventors: Arthur G. House, Kevin P. Klink, William J. Richman
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Patent number: 7442372Abstract: The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human ?-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (GAG) storage in cells of MPS I subjects to that of normal subjects. Intrathecal administration proved more effective than intravenous treatment at alleviating MPS I symptoms, indicating it is a useful method of treating lysosomal storage disorders.Type: GrantFiled: August 29, 2003Date of Patent: October 28, 2008Assignee: BioMarin Pharmaceutical Inc.Inventor: Emil D. Kakkis
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Patent number: 7442681Abstract: The present invention provides a method of regulating vascular permeability. A peptide inhibitor of p21-activated kinase has been found to inhibit the increase in vascular permeability induced by several factors. The present invention further provides methods of identifying regulators of vascular permeability. This peptide or other p21-activated kinase inhibitors should therefore be useful to treat disorders where vascular leak is a contributing factor.Type: GrantFiled: February 10, 2005Date of Patent: October 28, 2008Assignee: University of Virginia Patent FoundationInventors: Martin A. Schwartz, Rebecca A. Stockton
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Patent number: 7432070Abstract: An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteases. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a fluorescence quenching technique employing paramagnetic metal ions.Type: GrantFiled: June 14, 2004Date of Patent: October 7, 2008Assignee: Pierce Biotechnology, Inc.Inventors: M. Dean Savage, Timothy Jon McCauley, Sherri Z. Millis
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Patent number: 7417030Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.Type: GrantFiled: March 30, 2006Date of Patent: August 26, 2008Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Anjali Pandey, Robert M. Scarborough
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Patent number: 7407772Abstract: A method for screening statins in their open acid form to determine the susceptibility of each tested statin to metabolic glucuronidation is provided. Also provided is a method for determining if a non-statin pharmaceutical drug co-administered with a statin that is susceptible to metabolic glucuronidation in its open acid form, will inhibit the glucuronidation of the statin and thereby increase the risk of an adverse drug interaction.Type: GrantFiled: September 20, 2002Date of Patent: August 5, 2008Assignee: Merck & Co., Inc.Inventor: Thomayant Prueksaritanont
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Patent number: 7399476Abstract: The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.Type: GrantFiled: July 11, 2002Date of Patent: July 15, 2008Assignee: Werner LubitzInventors: Werner Lubitz, Wolfgang Haidinger
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Patent number: 7393638Abstract: The present invention relates to an assay system and methods for detecting SARS coronavirus (SARS-CV) from the samples (especially for urine) of suspected patient in the control of SARS to provide updated information of prognosis as well as the criteria for discharging a recovered patient from a hospital. The present invention also relates to an apparatus for performing the integration of thermal and magnetic control in the same apparatus to largely reduce the time of hybridization less than 20 minutes and the whole process of SARS-CV detection is less than 5 hours.Type: GrantFiled: July 1, 2003Date of Patent: July 1, 2008Assignee: AsiaGEN CorporationInventor: George Chin-Sheng Chou
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Patent number: 7390791Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.Type: GrantFiled: March 11, 2004Date of Patent: June 24, 2008Assignee: Gilead Sciences, Inc.Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
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Patent number: 7387803Abstract: A delivery system and method for delivering soluble dietary fibers in a chewable tablet form which is palatable and demonstrates a high degree of consumer acceptability.Type: GrantFiled: January 28, 2005Date of Patent: June 17, 2008Assignee: CNS, Inc.Inventor: Jerome J. Licari