Abstract: The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

Abstract: Non-invasive methods have been developed for the measurement of NO levels in a variety of fluid media, e.g., body fluids. The present invention embraces the use of a semi-permeable vessel wherein said vessel contains an NO reacting substance to trap NO diffusing thereinto, and a simple physical or chemical detection method to measure the levels of the end products. Since NO is a neutral gas molecule, it is capable of diffusing freely across a wide range of biocompatible polymer membranes which exhibit a high permeability to NO and other neutral gas molecules, such as O.sub.2 and CO.sub.2, but which are not permeable to charged molecules, such as NO.sub.3.sup.- or NO.sub.2.sup.-. The latter two compounds are ubiquitously present in body fluids and often interfere with the measurement of NO levels. The permeability of selected membranes to NO, but not to NO.sub.3.sup.- or NO.sub.2.sup.

Abstract: Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent, and a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer comprising the steps of administering to said individual a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent, and a therapeutically effective amount of a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radiostable active moiety are disclosed.

Abstract: The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. More specifically, the invention relates to polyclonal and monoclonal antibodies that bind PUR or PUR related proteins. Antibodies that bind PUR protein and which neutralize. PUR activity may be used to treat hyperproliferative diseases such as cancer.

Abstract: A `docking` method based on finite grid forcefield sampling makes use of fast evaluation of interaction energies between molecules, such as macromolecules and ligands. The forcefield used to calculate interaction energies utilizes a potential energy function composed of a 1/r dependent electrostatic term and a (6-12) Lennard-Jones term for Van der Waals interactions. Successful prediction of ligand position and determination of ligand-protein interaction enthalpy is done by mapping potential energy field components of one of the molecules onto a energy field component grids, and mapping interaction field components of another of the two molecules onto interaction component grids.

Abstract: A peptide comprising a free terminal alpha amine is treated with an aryl sulfonamide activating agent, resulting in an activated amide. The resulting activated amide is deprotonated with a base and modified by the addition of a substituent group. The aryl sulfonamide activating group is cleaved using a nucleophilic substitution reaction. The method is particularly useful for the modification of peptides at specific N-alpha positions, and is compatible with conventional solid phase peptide synthesis, including those that utilize Fmoc protecting groups.

Abstract: The present invention relates to novel tetrahydro-quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and Y have the meanings provided.

Abstract: A method is provided for assembling an exhaust processor including a housing formed from a tube having an inlet end and an outlet end, an internal inlet cone shield, a substrate, and an internal outlet cone shield. The housing includes an inlet end and an outlet end. The inlet end of the tube is sized down to a desired inlet diameter to form the inlet end of the housing. The internal inlet cone shield is installed into the tube through the outlet end of the tube. The substrate is inserted into the tube through the outlet end of the tube. The internal outlet cone shield is installed into the tube through the outlet end of the tube. The outlet end of the tube is sized down to a desired outlet diameter to form the outlet end of the housing.

Abstract: A method for forming an injection molded component from a host polymer (18) uses a very small quantity of an additive (32) that is efficiently driven to the surface of the component during the injection molding process. The additive exists in the host polymer at a very low concentration in the bulk, much lower than would be necessary to achieve the modification in a homogeneous blend. The additive is an insoluble liquid in the host polymer under the temperature and pressure conditions of injection molding. The additive is driven to the flow front surface (22) during injection molding and then translated to the surface (24) of the component by fountain flow and is distributed on the surface in a thin layer, producing the desired surface modification, without altering the properties of the bulk polymer, and eliminating post processing steps from the manufacturing process.