Patents Examined by Julie K. Parker
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Patent number: 4886908Abstract: (R)-4-amino-3-hydroxybutyric acid is prepared from the hydrochloride of the methyl ester or ethyl ester of (2S, 4R)-4-hydroxyproline via the intermediary stages of the corresponding, non-isolated (R)-4-hydroxy-1-pyrroline-2-carboxylic acid ester and the isolated (R)-4-hydroxy-2-pyrrolidone. The (R)-4-amino-3-hydroxybutyric acid which is useful for pharmacological purposes is obtainable in a high yield according to this method.Type: GrantFiled: February 29, 1988Date of Patent: December 12, 1989Assignee: Degussa AktiengesellschaftInventor: Johannes Haeusler
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Patent number: 4886835Abstract: Substituted alkadienes of the formula: ##STR1## in which R.sub.1 is hydroxy or acetoxy, R.sub.2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, andR.sub.3 is alkylthio or alkoxy and R.sub.4 is naphthoyl or optionally substituted benzoyl,or R.sub.3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R.sub.4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio,or R.sub.3 and R.sub.4 form, with the carbon atom to which they are attached, a ring-system of formula: ##STR2## in which R.sub.5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.Type: GrantFiled: September 26, 1988Date of Patent: December 12, 1989Assignee: Rhone-Poulenc SanteInventors: Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel
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Patent number: 4886898Abstract: Certain intermediate aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivatives of the formula ##STR1## in which R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,which are useful in preparing the corresponding aryl-sulfonamides which in-turn have antithrombotic, antiatherosclerotic and antiischaemic properties.Type: GrantFiled: May 16, 1989Date of Patent: December 12, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
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Patent number: 4883903Abstract: The subject of the invention is a novel procedure for the preparation of the compounds of formula I: ##STR1## in which n varies in particular from 2 to 5 and R represents Cl, Br or FZ represents in particular hydrogen, characterized in that the halogenoformate of formula II: ##STR2## R and n having the meanings indicated above, Y representing a halogen, is made to react with NH.sub.2 CH.sub.2 CH.sub.2 Cl to form the compound of formula Ia: ##STR3## in which R has the meanings indicated above, and in that the compound Ia is treated directly with nitrosylsulfuric acid.Type: GrantFiled: April 22, 1988Date of Patent: November 28, 1989Assignee: SanofiInventors: Pierre Roger, Jean-Paul Fournier, Rolande Leroy
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Patent number: 4871769Abstract: Tetrachlorobenzoic acid derivative having the formula: ##STR1## (2-trichloroacetoxy-3,4,5,6-tetrachlorobenzoic acid), chemotherapeutically active against cutaneous and subcutaneous benign neoformations, process for its preparations and compositions containing the same.Type: GrantFiled: February 5, 1987Date of Patent: October 3, 1989Assignees: Wiktor Djaczenko, Maria StrumilloInventors: Gianfranco Fedeli, Giuseppe Diamantini, Wiktor Djaczenko, Maria Strumillo
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Patent number: 4868332Abstract: An aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivative of the formula ##STR1## in which R.sup.3 is aryl or substituted aryl,R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,and physiologically acceptable salts thereof with monovalent or divalent cations which have antithrombotic, antiatherosclerotic and antiischaemic activities.Type: GrantFiled: November 23, 1987Date of Patent: September 19, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
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Patent number: 4868331Abstract: Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, andR.sup.5 and R.sup.6 each independently is hydrogen or alkyl, orone of the radicals R.sup.5 or R.sup.6 is benzyl,and physiologically acceptable salts thereof with mono- and divalent cations.Type: GrantFiled: June 29, 1987Date of Patent: September 19, 1989Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Bodo Junge, Elisabeth Perzborn, Friedel Seuter, Volker-Bernd Fiedler
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Patent number: 4855491Abstract: A method for the continuous, catalytic production of an aromatic carboxylic acid product by liquid-phase, exothermic oxidaion of an aromatic alkyl with an oxygen-containing gas and a solvent medium in an oxidation reactor and utilizing reverse osmosis is disclosed. In particular, a multiple ingredient or component-containing slurry product stream is withdrawn from the reactor, the slurry product stream is then separated to produce a product-containing stream and at least one mother liquor stream which contains, in addition to a number of desirable process stream components, such as oxidation reaction catalysts, a number of undesirable process stream impurities. The impurities are selectively removed from the mother liquor stream by passing at least a portion of the mother liquor stream through a reverse osmosis separation device to produce a catalyst-bearing stream having a relatively lesser impurities-to-catalyst weight ratio and a purge stream having a relatively greater impurities-to-catalyst weight ratio.Type: GrantFiled: April 25, 1988Date of Patent: August 8, 1989Assignee: Amoco CorporationInventors: Calvin T. Chew, John C. Gee
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Patent number: 4855323Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.Type: GrantFiled: July 22, 1988Date of Patent: August 8, 1989Assignee: Hoechst AktiengesellschaftInventors: Gunther Wess, Wilhelm Bartmann, Gerhard Beck, Hiristo Anagnostopulos
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Patent number: 4855487Abstract: An improved process for preparing a fluorine-containing carboxylic acid ester useful as an intermediate for producing a fluorine-containing carboxylic acid is disclosed. The process comprises reacting a fluorine-containing alkyl halide with carbon monoxide and an alcohol in the presence of a transition metal catalyst of the Group VIII of the Periodic Table and a base, and provides the desired carbonylated compound in high yield.Type: GrantFiled: July 10, 1987Date of Patent: August 8, 1989Assignee: Sagami Chemical Research CenterInventors: Takamasa Fuchikami, Hisao Urata, Yoshimitsu Ishii, Yoshiko Obata
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Patent number: 4851440Abstract: Leukotriene antagonists, processes for the preparation thereof, the use thereof for the treatment of diseases, and precursors.Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X have the indicated meanings, processes for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds are described. In addition, precursors for the preparation of compounds of the formula I are described.Type: GrantFiled: July 22, 1988Date of Patent: July 25, 1989Assignee: Hoechst AktiengesellschaftInventors: Gerhard Beck, Peter Below, Andreas Bergmann
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Patent number: 4845267Abstract: Alkyl esters of 2-fluoro-1-methoxyethylcarbamic acid, which are useful intermediates in the preparation of compounds, such as 4-amino-5- fluoropentanoic acid, are prepared by the electrochemical anodic oxidation of esters of 2-fluoroethylcarbamic acid in the presence of methanol and an electrolyte.Type: GrantFiled: February 11, 1988Date of Patent: July 4, 1989Assignee: The Dow Chemical CompanyInventors: James M. Renga, Charles K. Bon, Aylin H. Gulkenkian, Michael G. Smith
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Patent number: 4841097Abstract: Disclosed herein are dialkanoyloxybenzylidene dialkanoate represented by the formula ##STR1## wherein X.sup.1 and X.sup.2 represent respectively alkanoyloxy group and a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of inflammatory disease of the dialkanoyloxybenzylidene dialkanoate as an active ingredient thereof.Type: GrantFiled: April 13, 1988Date of Patent: June 20, 1989Assignee: Kureha Kagaku Kogyo Kabushiki KaishaInventors: Hitoshi Takita, Fumihiko Kimura, Sakuo Noda, Yutaka Mukaida, Toyohiko Nitta, Hidetoshi Kobayashi
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Patent number: 4831186Abstract: Pentafluorosulfanyl polynitroaliphatic explosive compounds of the formulas ##STR1## where R is --CH.sub.2 C(NO.sub.2).sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 C(NO.sub.2).sub.3, --CH.sub.2 CF(NO.sub.2).sub.2, and --CH.sub.2 C(NO.sub.2).sub.3 ; ##STR2## where R is --CH.sub.2 C(NO.sub.2).sub.2 CH.sub.2 --, --CH.sub.2 C(NO.sub.2).sub.2 CH.sub.2 OCH.sub.2 OCH.sub.2 C(NO.sub.2).sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 N(NO.sub.2)CH.sub.2 CH.sub.2 N(NO.sub.2)CH.sub.2 CH.sub.2 --, and --CH.sub.2 CH.sub.2 N(NO.sub.2)CH.sub.2 C(NO.sub.2).sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --.Type: GrantFiled: June 24, 1988Date of Patent: May 16, 1989Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael E. Sitzmann, William H. Gilligan