Abstract: A connector is configured to connect a drug container with a solution container and permit contents of the drug container to be combined with the solution container. The connector has a connector body with a first coupling for fluid connection with the drug container. The first coupling defines a first fluid passage. The connector body also has a second coupling for fluid connection with the solution container. The second coupling defines a second fluid passage. A control valve has a movable valve body that defines a third fluid passage. The valve body is positionable relative to the connector body in a first position, in which the first fluid passage is sealed from the second fluid passage. The valve body is also positionable in a second position, in which the first fluid passage is connected in fluid communication with the second fluid passage by the third fluid passage.

Abstract: A pouch for transporting and/or processing a biopharmaceutical fluid, the pouch comprising a flexible wall, the flexible wall comprising a shape memory material being adapted to change shape when induced by an external stimulus, so that the pouch can be alternately in a collapsed state and in an unfolded state, the wall of the pouch in the unfolded state delimiting a closed internal cavity adapted to contain the biopharmaceutical fluid.

Abstract: An instrument for isolating candidate eyelashes to attach prostheses includes an instrument tip which has a tip aperture. A candidate eyelash is disposed in a distal slot of the tip aperture. The instrument tip is advanced relative to the candidate eyelash and the instrument tip applies a force to eyelashes that are adjacent to the candidate eyelash. The application of the force actuates the eyelashes that are adjacent to the candidate eyelash away from the candidate eyelash. The candidate eyelash is actuated into an open area of the tip aperture and a prosthesis is attached to the candidate eyelash.

Abstract: Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, a medical device is configured to detect an identity of a patient-contacting disposable connected to the medical device. The medical device automatically modifies one or more operational parameters of the medical device based on the identity of the patient-contacting disposable connected to the medical device. The medical device can include a user interface and modify automatically available selections in the user interface based on the identity of the patient-contacting disposable connected to the medical device.

Abstract: In some embodiments, an apparatus for providing negative pressure wound therapy to multiple wounds includes a negative pressure source configured to couple via a plurality of fluid flow paths to a plurality of wound dressings. The plurality of flow paths includes a plurality of calibrated leaks. The apparatus also includes a controller configured to determine a total rate of flow in the plurality of fluid flow paths and compare the total rate of flow to a plurality of thresholds associated with the plurality of calibrated leaks to determine one or more operating conditions, such as a blockage in one or more of the plurality of flow paths. An indication of the operating condition can be provided.

Abstract: Various systems and methods are provided for treating pulmonary edema. In general, a pump can be configured to be implanted within a patient at risk of developing edema. The pump can be configured to pump fluid out of the patient's lungs, e.g., out of the patient's interstitial and alveolar spaces. The pump can be configured to be fully implanted within the patient's body. The pump can be configured to continuously pump fluid, or the pump can be configured to be selectively actuatable in response to a trigger event. In an exemplary embodiment, the pump can include an inflow port coupled to an inflow tube in fluid communication with a lymphatic vessel of the patient, and can include an outflow port coupled to an outflow tube in fluid communication with a vein of the patient.

Abstract: A urinary catheter is described that can be retained inside the body for extended periods. A catheter mating device can connect to the catheter to move the catheter inside of the body or remove it from the body. The catheter includes one or more of: (1) a retention portion having an outer cover, an inner cavity, and at least one structure in the inner cavity that exerts outward force on the outer cover, and (2) an extendable flap at the catheter's distal end. The retention portion and/or extendable flap each are configured to retain the catheter in the proper position inside of a user's body.

Abstract: A drainage device may include a catheter including a proximal end and a distal end. The drainage device may further include a hub coupled to the proximal end of the catheter. The hub may include a fastener element configured to secure the distal end of the catheter. In some aspects, the fastener element may be a hinged element. In some aspects, the drainage device may further include a puncture element including a tip and an expander portion. In still other aspects, the puncture element may also include an attachment portion.

Abstract: A vented chest wound seal for a penetrating chest wound includes a flexible sheet including a top surface and a bottom surface, an adhesive hydrogel layer covering a portion of the bottom surface of the flexible sheet, and a plurality of vent channels. The adhesive hydrogel layer includes an inner perimeter and an outer perimeter, and the outer perimeter forms a continuous perimeter of hydrogel along a bottom surface of the flexible sheet. A plurality of vent channels, each including a first opening to a space inside of the inner perimeter, extend radially outward to an outer terminal end vent to the top surface of the flexible sheet. The outer terminal end is spaced apart from the outer perimeter of the adhesive hydrogel layer towards the central portion of the chamber.

Abstract: The present invention provides a cannulation device for administering an active agent containing composition to the suprachoroidal space or supraciliary space. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides compositions for use in a method of treatment of an ocular disease or condition for delivery into the suprachoroidal space or supraciliary space.

Abstract: An implantable device having a reservoir for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and include a retention structure and a penetrable element coupled to and extending within at least a portion of the proximal end region of the device. The device includes a porous drug release element is positioned in fluid communication with an outlet of the device and a reservoir having a volume configured to contain one or more therapeutic agents in fluid communication with the outlet through the porous drug release element. The device is at least partially inserted along an axis of insertion.

Abstract: Urinary catheter-insertion kits can include a working tray, a storage tray, a urinary catheter, and a drainage system including drainage tubing and a drainage receptacle. The working tray can be configured to nest with the storage tray by suspending the working tray from the storage tray. At least the working tray includes a number of preformed sections configured to hold a number of components of the urinary catheter-insertion kit. At least one section of the preformed sections of the working tray includes a catheter section configured to hold the urinary catheter. The storage tray can be configured to hold the drainage system. Methods of urinary catheterization include use of the urinary catheter-insertion kits.

Abstract: Systems and methods for monitoring for an occlusion in an aspiration line during an ophthalmic surgical procedure. An ophthalmic surgical system may include a first aspiration pump located in a handpiece, a second aspiration pump located away from the handpiece such as in a console, and a pressure sensor located between the first aspiration pump and the second aspiration pump. The pressure sensor is adapted to monitor for an occlusion in the aspiration line upstream of the first aspiration pump. The second aspiration pump may be operated at the same flow rate as the first aspiration pump and/or to maintain a constant pressure between the second aspiration pump and the first aspiration pump. Systems and methods as disclosed allow for a handpiece pump located close to the working tip while providing reliable occlusion detection with a pressure sensor located away from the handpiece.

Abstract: In some embodiments, a catheter device may include a catheter including a proximal end and a distal end. The catheter device may further include a connector coupled to the proximal end of the catheter. The connector may include a base having a recess configured to receive the distal end of the catheter and may include a hinged portion configured to couple to the base to clamp the catheter within the recess.

Abstract: Embodiments include a vacuum assisted venous drainage (VAVD) system, including a regulator valve assembly configured to facilitate application of vacuum to a reservoir; a control unit configured to control the regulator valve assembly to facilitate controlling application of the vacuum; at least one pressure sensor coupled to the reservoir and configured to obtain pressure measurements of pressure in the reservoir; a heating element configured to heat the regulator valve assembly to a target temperature; and at least one temperature sensor configured to determine a temperature of the regulator valve assembly.

Abstract: A canister lid (101) for a canister (102) includes an annular perimeter (103) surrounding an interior portion (104). Rather than completely surrounding the interior portion, the annular perimeter is instead interrupted by a suction conduit (112) defined by a suction conduit (112) separating a first lobe (117) and a second lobe (118). The suction conduit (112) intersects the annular perimeter such that the first lobe is disposed interior of the annular perimeter while the second lobe is disposed exterior to the annular perimeter. The canister lid can further include one or more ports (110,111) extending from the interior portion. A canister (102) can include a valve (401) and can optionally be coupled to a hub mount vacuum source (1200) or a hub mount stand (1800).

Abstract: A medical system including a compressible device, and a covering over the compressible device, wherein the covering includes a delivery configuration and a deployed configuration, wherein, in the delivery configuration, the covering at least partially covers the compressible device to maintain the compressible device in a compressed state, and wherein, in the deployed configuration, the covering is releasable from the device to transition the compressible device from the compressed state to an expanded state.

Abstract: A vial adaptor assembly, suitable for use with a vial containing a medicament and a syringe adaptor, which is in turn connectable to a syringe having a piston adapted for selectable displacement in a first direction for drawing fluid into the syringe and in a second direction for expelling fluid from the syringe, the vial adaptor assembly including: a vial connector for non-removable connection with the vial containing a medicament; a syringe adaptor connector for connection with the syringe adaptor; a pressure equalization chamber having a variable volume, which is sealed from the outside environment during use; a liquid pathway communicating between an interior of the vial containing the medicament and an interior of the syringe when the syringe adaptor is connected to the syringe adaptor connector and the syringe is connected to the syringe adaptor and the vial connector is connected to the vial containing the medicament; and a venting pathway communicating between the interior of the vial containing the m

Abstract: An ostomy output diversion device is used to cover and seal closely around a patient's stoma, to divert stoma effluent output through the device, through a drain tube and into a container or reservoir, temporarily eliminating the need of an adhesive-based ostomy pouching system. The ostomy output diversion device is placed over the person's stoma, with the base ring surrounding the peristomal skin, the adjustable inner tube is retracted until the base ring is centered over the stoma, the body support strap is then placed over the device to secure it to the patient's body, the inner tube with stoma-sized adapter is then extended over the stoma, the patient applies the desired pressure against the skin, then secures the stoma-sized adapter in place with the pressure adjustment lock. The device may also include an ostomy pouch mounting ring for attachment to an ostomy pouch, and a disposable receptacle.

Abstract: A top for a plasma storage container includes a top body that defines the structure of the top and seals an opening of the plasma storage container. The top also includes a first opening and a vent opening extending through the top body. A septum is located at least partially within the first opening and includes an aperture therethrough. The septum allows a blunt cannula to pass through the aperture to access the interior of the plasma storage container. The top also includes a hydrophobic membrane located on underside of the top body. The membrane covers the vent opening and allows air to vent through the vent opening during plasma collection.