Abstract: The present invention relates to a method of treating newborn hypoxic-ischemic encephalopathy (NHIE). Such method comprises administering the phytocannabinoid cannabidiol (CBD) in combination with therapeutic hypothermia to a newborn subject suffering from NHIE. Preferably the CBD is in the form of a plant extract, alternatively the CBD is in a pure or isolated form.

Abstract: Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and/or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these apparatuses and methods apply and maintain one or more target “warm” temperatures to a subject's forehead for a time period. The target temperature may be between 25° C. and 42° C. The target temperature may be a fixed amount greater than ambient temperature. The time period may be a fixed time period or a variable time period. These methods and apparatuses may limit the application of thermal energy to the subject's forehead region.

Abstract: A method for regulating immune cells includes applying a stimulus to a specific area to be stimulated at a body surface by a stimulus applying apparatus so as to bring an increase rate of a blood flow to 60% or more, preferably, 100% or more. The blood flow is measured by a laser Doppler tissue blood flow meter attached to a central part of an inner side of a wrist joint. The regulating and balancing these T cell groups finely is essential to maintain the immune system of human beings and increase in blood flow volume by thermal therapy enables a regulatory T cell to regulate and balance the immune cells.

Abstract: A pneumatic cooling device including a housing having a first end and a second end. A handle extends from an outer surface of the housing. An inlet is positioned at substantially the first end of the housing and is configured to receive a supply of medical grade air into the housing. An outlet is positioned at substantially the second end of the housing and is configured to deliver the supply of medical grade air outside of the housing. A pathway extends through the housing between the inlet and the outlet and is configured to passively move the supply of medical grade air between the inlet and the outlet.

Abstract: Microwave catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a microwave transmission element to a renal artery via an intravascular path. Renal neuromodulation may be achieved via dielectric heating in the presence of microwave irradiation that modulates neural fibers that contribute to renal function or alters vascular structures that feed or perfuse the neural fibers.

Abstract: Disclosed is a system which employs a cooling or heating pad which is preferably a thin, flexible pad for placement at an intended area of the body. The pad includes a layer of highly conductive material which can be cooled or heated using a portable source of heat or cold material delivered to the conductive material by a delivery conduit. Valves can be included to regulate flow of the cooling or heating material from the source to the pad. The system can also include a dual-chambered canister for containing two different media for heating, cooling or for alternating heating and cooling the pad.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

Abstract: Systems and methods that enable delivery of radiofrequency energy and cryotherapy applications to adipose tissue for reduction and contouring of body fat are described herein. Aspects of the disclosure are directed to methods for reducing surface irregularities in a surface of a subject's skin resulting from an uneven distribution of adipose tissue in the subcutaneous layer. The method can include delivering capacitively coupled or conductively coupled radiofrequency energy to a target region of the subject at a frequency which selectively heats fibrous septae in a subcutaneous layer of the target region to a maximum temperature less than a fibrous septae denaturation temperature. Furthermore, the method can include removing heat such that lipid-rich lobules in the subcutaneous layer are affected while non-lipid-rich cells and lipid-rich regions adjacent to the fibrous septae are not substantially affected.

Abstract: In one embodiment, controlling the spatial distribution of an electromagnetic field in a system involves determining an inflection frequency for energy applied to the system below which a first spatial distribution results and above which a second spatial distribution results, selecting an excitation frequency to be used to generate an electromagnetic field to be applied to the system based upon the determined inflection frequency, and applying an electromagnetic field generated using the selected excitation frequency.

Abstract: Methods, devices and systems for improving sleep (including reducing sleep onset and maintenance of sleep duration), enhancing, or increasing sleep, including (but not limited to) treating sleeping disorders such as insomnia.

Abstract: A radio frequency annular phased array hyperthermia system providing a relatively small heated focal zone in a relatively large tissue mass includes a plurality of radio frequency energy applicators in at least one ring adapted to surround the relatively large tissue mass. A bolus having a dielectric constant is positioned between the energy applicators and the tissue mass. The energy applicators operate at a frequency high enough to create the relatively small heated focal zone. The spacing between adjacent applicators in the at least one ring is less than a critical distance and spacing between adjacent rings when the at least one ring is a plurality of side by side rings is less than a critical distance with such critical distances being interdependent on the frequency of the energy radiated, the dielectric constant of the bolus, the size of the bolus, and the size of the relatively large tissue mass.

Abstract: A cooling system for an occupant of an occupant support comprises a coolant conduit having an inlet for receiving coolant and an outlet for discharging the coolant to a destination. The conduit is nonpermanently and manually shape adjustable, shape stable subsequent to adjustment, and removably securable to the occupant support, the occupant or both. In one embodiment the destination is an ambient environment selected to achieve targeted coolant delivery to a localized region of the occupant's body. A cooling glove to be worn by a user has at least one coolant intake and at least one of a) a coolant passage extending from the coolant intake to an exhaust opening which exhausts coolant to an ambient environment; and b) a cooperative relationship with the user which defines a fluid pathway bounded in part by the glove and in part by the user and which discharges coolant to an ambient environment.

Abstract: A robotic surgery system comprises a mounting base, a plurality of surgical instruments, and an articulate support assembly. Each instrument is insertable into a patient through an associated minimally invasive aperture to a desired internal surgical site. The articulate support assembly movably supports the instruments relative to the base. The support generally comprises an orienting platform, a platform linkage movably supporting the orienting platform relative to the base, and a plurality of manipulators mounted to the orienting platform, wherein each manipulator movably supports an associated instrument.

Abstract: Devices and methods for contactless skin treatment use feedback power control for non-invasive treatment of skin and human tissue. Electromagnetic energy heats skin or tissue. A feedback system measures an output physical quantity before the output of electromagnetic waves from the device into the patient. Alternatively the feedback system scans values of a physical quantity on or near the patient. The devices and methods allow for delivering the optimum amount of energy to the patient while reducing the thermal load of the device.

Abstract: An extender for use in an electro-mechanical surgical system includes a surgical attachment that may be detachably coupled to an electro-mechanical driver device via a flexible shaft. The extender is a substantially rigid extender that includes a proximal end that may be detachably coupled to a distal end of the flexible shaft. The extender also includes a distal end that may be detachably coupled to the surgical attachment. The extender also includes at least one rotatable drive shaft configured to engage and be secured with a respective rotatable drive shaft of the flexible shaft such that rotation of the respective rotatable drive shaft of the flexible shaft by the electro-mechanical driver device causes the at least one rotatable drive shaft of the extender to rotate, thereby rotating a complementary connector of the surgical attachment so as to operate the surgical attachment.

Abstract: Devices and methods for warming or cooling blood flowing through the vasculature of a human or animal subject so as to alter or control the temperature of all or part of the subject's body. Heat exchangers are positioned within the subject's vasculature and heated or cooled heat exchange fluid is circulated through the heat exchanger. For certain therapeutic applications, the heat exchanger and associated elements of the system have sufficient power to lower the subject's body temperature by at least 3 degrees C. in less than 30 minutes.

Abstract: Devices and methods for providing therapeutic heating are disclosed herein. In one embodiment, the system includes a device body configured to provide heat to a portion of skin. The device body also includes a low-level heating region and a high-level heating area. The low-level heating region provides a continuous amount of heat at a first temperature, and the high-level heating area provides an intermittent amount of heat at a second temperature greater than the first temperature.

Abstract: A steam-generative warming device 10 having a steam generating element 30 that releases steam in association with heat generation accompanying the oxidation of an oxidizable metal. The steam generative warming device 10 contains a capsaicin analog and a menthol in a capsaicin analog/menthol mass ratio of 1/300 to 1/20000. It is preferred that the capsaicin analog be present in an element adapted to be brought into direct contact with the user's skin and the menthol be present in an element adapted not to be brought into contact with the user's skin.

Abstract: Therapeutic jewelry is provided that can provide a therapeutic heating or cooling effect to a user. The therapeutic jewelry includes a thread, a first therapeutic container portion, a second therapeutic container portion, and a cap. The first therapeutic container portion defines a first internal cavity, includes a receiving member extending across, and has a hollow interior open at opposite sides of the first therapeutic portion to receive the thread there through. The second therapeutic container portion defines a second internal cavity and is connectable to the first container portion forming a jewelry element body such that the first and second internal cavities cooperatively form an interior fluid cavity. At least one of the first or second container portions define a filling aperture open to the interior fluid cavity of the jewelry element body, enabling filling the interior fluid cavity.

Abstract: A conditioning garment has an array of tubes (11) for passing heated/cooled fluid to heat/cool a wearer of the garment. The array of tubes (11) terminate at a connector (16) for connection to a source of heated/cooled liquid. The connector (16) comprises a male part (15) and a female part (17) with a releasable latch (22, 34, 40) acting between the male and female parts (15, 17) to hold the male part (15) in engagement with the female part (17). The releasable latch includes a release member (40) moveable in a rectilinear path away from the connector (16) to release the latch and allow separation of the male part (15) from the female part (17). The male and female parts (15, 17) are self-sealing on disengagement. This allows for automatic separation of the male and female parts (15, 17) in an emergency.