Abstract: A transcatheter valve prosthesis is disclosed that has a compressed, delivery configuration and an expanded configuration for deployment within a native heart valve. The valve prosthesis includes a self-expanding frame and a prosthetic valve component. The self-expanding frame includes a valve receiving portion defining an opening therethrough and first and second anchors at opposing ends of the valve receiving portion. The valve receiving portion is substantially planar and the first and second anchors are oriented substantially perpendicular to the valve receiving portion when the valve prosthesis is in the expanded configuration. The prosthetic valve component is disposed within the opening of the valve receiving portion and secured thereto.

Abstract: User interface devices for manipulating a robotic surgical tool in a surgical robotic system are described. A user interface device can include a device body containing a tracking sensor to generate a spatial state signal in response to movement of the device body. The spatial state signal can be used to control a spatial motion of a surgical robotic system actuator. Several grip linkages can be pivotally coupled to the device body. A grip linkage displacement sensor may monitor movement of the grip linkages relative to the device body, and generate a grip signal in response to the movement. The grip signal can be used to control a grip motion of a robotic surgical tool mounted on the surgical robotic system actuator. Other embodiments are also described and claimed.

Abstract: A cranial implant may include an interior guide portion, an exterior guide portion, and one or more flanges. In one example, the interior guide portion may be disposed in a burr hole of a cranium and include a distal end, a proximal end, an inner surface, and an outer surface. The distal end may be inserted further into the burr hole than the proximal end. The inner surface may at least partially define a channel that accepts an elongated member, and the outer surface may extend around the full circumference of the burr hole. The exterior guide portion may be coupled to the interior guide portion and may contact an external surface of the cranium. The interior guide portion may define one or more surface features configured to secure the interior guide portion to the burr hole or secure an elongated member within the channel of the cranial implant.

Abstract: A system for retrieving material or objects from a biological vessel is provided. the system includes an elongated braid structure configured for transitioning between collapsed and expanded states, the elongated braid structure surrounding a lumen having a distal opening when in the expanded state. The system further includes a closure wire positioned along a length of the elongated braid structure, the closure wire being actuatable to pull inward a distal portion of the elongated braid structure and thereby at least partially close the distal opening.

Abstract: A fixation device for graft placement and ligament suspension. The fixation device includes a strand of suture having a first limb and a second limb with a midpoint therebetween. The suture includes a first splice in the first limb and a second splice in the second limb. A first free end of the first limb extends through the second splice, forming a first loop with a diameter. A second free end of the second limb extends through the first splice, forming a second loop with a diameter. Tensioning the first free end reduces the diameter of the first loop and tensioning the second free end reduces the diameter of the second loop. The fixation device may include a button having the first and second limbs of suture woven therethrough such that the first and second free ends extend proximally from the button and the loops extend distally from the button.

Abstract: The present invention refers to a dural sealing system (100) comprising an implant (10), joined to a guiding thread (20); a transfer device (30), provided with a grip portion (30a) and a hollow portion (30b), said hollow portion (30b) terminating, at a first end, in a nozzle (30c) that can be coupled to an epidural needle (200), said hollow portion (30b) also terminating in a second end fitted with an entry region (30d); and an introductory device (70) comprising a tube (70a) with a hollow interior section, provided with a first free end and a second closed end, attached to a stop (70b).

Abstract: A system for replacing a heart valve of a patient. The system includes a delivery device and a prosthetic heart valve. The system is configured to be transitionable between a loaded state, a partially deployed state and a deployed state. In the loaded state, the prosthetic heart valve engages a coupling structure and is compressively retained within a primary capsule, which constrains the prosthetic heart valve in a compressed arrangement. In the partially deployed state, the prosthetic heart valve engages the coupling structure and is compressively retained within a secondary capsule, which constrains the prosthetic heart valve to a partially deployed arrangement. The partially deployed arrangement is less compressed than the compressed arrangement and less expanded than a deployed arrangement. In the deployed state, the primary and secondary capsules are retracted from over the prosthetic heart valve, which expands to the deployed arrangement and is released from the coupling structure.

Abstract: In one embodiment, a multi-layer suture fastener that includes a generally disc-shaped body defining a plurality of axially spaced-apart layers. Each layer can include an inner axial surface and an outer axial surface. A suture opening can extend from the inner axial surface to the outer axial surface of each layer. The suture openings can have an open configuration and a closed configuration. One or more lines of suture can be passed through the suture openings when in the open configuration. The suture openings can be placed in the closed configuration. In the closed configuration, the one or more lines of suture can be restricted by radial surfaces of the suture opening from sliding through the suture openings in at least one longitudinal direction of the one or more lines of suture.

Abstract: A retrieval device may have a contracted state and an expanded state. The retrieval device may include a sheath and at least three support members. Each of the support members may have a first portion with a first cross-sectional shape and a second portion with a second cross-sectional shape different from the first cross-sectional shape. A proximal end fixed of each of the support members may be coupled to the sheath, and a distal end may be movable relative to the sheath. The retrieval device may further include at least three movable members movable relative to the support members. Each movable member may extend through a lumen of one support member of the at least three support members and through a lumen of a different support member of the at least three support members.

Abstract: Designs are disclosed for devices capable of removing both firm and soft clots from body vessels that can have dual layers where an inner expandable body of cells runs within an outer expandable cage of cells. The designs can feature a constrained delivery configuration and an expanded deployed configuration. An outer cage can have wide opening struts to allow for clot integration into the device. Both the inner body and outer cage can be configured with shapes to pinch a clot in addition to embedding in it. The devices can also be capable of having a portion of the outer cage fold and invert proximally after engaging with a target clot to internalize it. These factors can increase the device's ability to capture clots of all compositions, allowing for safer and more efficient flow restoration.

Abstract: A needle driver can include a first jaw hosting a first shaft and a second jaw hosting a second shaft. The first shaft hosts a first roller and a first set of teeth. The second shaft hosts a second roller and a second set of teeth. The second jaw moves relative to the first jaw between an open position and a closed position. The first set of teeth meshes with the second set of teeth when the second jaw is in the closed position such that (a) the first set of teeth can drive the second set of teeth and (b) the first roller and the second roller can drive a needle therebetween when the first set of teeth drives the second set of teeth.

Abstract: A surgical clip applier is provided that includes first and second jaws on a distal end of an elongate shaft, a clip advancing assembly extending through the shaft and configured to advance a distal-most clip from a plurality of clips in the shaft into the first and second jaws. The jaws have opposed inward facing surfaces, and each inward facing surface has a clip track defined therein for receiving and guiding legs of a clip into the first and second jaws. The clip track of at least one of the jaws has at least one deflectable clip retention member disposed therein and configured to apply a biasing force to a leg of a clip disposed within the jaws to thereby retain the clip within the jaws and maintain alignment of the clip with respect to the jaws. The clip track of at least one of the jaws may also have at least one recess or protrusion designed to be complementary to and mate with a protrusion or recess in a clip.

Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. The balloon includes a cutting member mounted on an exterior surface of the balloon which includes one or more features for providing the cutting member with enhanced flexibility for navigating tortuous anatomy and more closely conforms to the expansion characteristics of the balloon to which the cutting member is mounted.

Abstract: The invention belongs to the field of interventional medical instruments, and relates in particular to a thrombus removal device used for removing a thrombus in a blood vessel. The thrombus removal device includes an elongated delivery member and a plurality of thrombus removal members disposed on the elongated delivery member; the thrombus removal member has a compressed configuration and an expanded configuration formed from the compressed configuration by means of self-expansion; and at least one thrombus removal member among the plurality of thrombus removal members is rotatably connected to the elongated delivery member. By means of causing the thrombus removal member to have rotational degrees of freedom, the thrombus removal device provided by the present invention enables a thrombus to enter the thrombus removal member more easily by means of a thrombus entrance so that the thrombus removal member may fully contact the thrombus, thereby achieving effective capture of the thrombus.

Abstract: A retrieval device can include inwardly facing protruding features that facilitate engagement and capture of a thrombus or other mass from a body lumen of a patient. The protruding features can deploy from a frame of the retrieval device to extend radially inwardly toward an opposing side of the frame. When deployed into a thrombus, the protruding features engage and urge the thrombus as the retrieval device moves to facilitate capture.

Abstract: A clot removal device has a segment that has two main struts that serve as a frame for holding a plurality of secondary struts. Each of the two main struts has a proximal end that is connected at a proximal point of the segment and extends along a generally circumferential path, with each main strut terminating at a separate connecting point that is distal from the proximal point. The connecting points are connected to each other to form a generally tubular structure defining an inner lumen. The plurality of secondary struts forms a lattice of cells, with each cell surrounded by four secondary struts. Two generally straight distal struts are connected to the lattice of cells at a distal end of the segment, and are connected to each other to form a distal point. A distal opening is defined by the cells adjacent the distal struts, the distal opening communicating with the lumen and terminating at the proximal point.

Abstract: A clot removal device including a first scaffolding section, a second scaffolding section distal of the first scaffolding section by a first hinged element including a pinching cell. The pinching cell has a collapsed state and an expanded state configured to pinch at least a portion of a clot. A third scaffolding section is distal of the second scaffolding section by a second hinged strut element including a pinching cell that has a collapsed state and an expanded state configured to pinch at least a portion of the clot. An outer diameter of the third scaffolding section is greater than an outer diameter of the second scaffolding section, which is greater than an outer diameter of the first scaffolding section.

Abstract: In embodiments of an obstruction removal device, system, and/or method, a removal tool is disposed at a distal end of a delivery tool and configured to at least partially separate an obstruction from an inner surface of a vasculature. An expandable member is also coupled to the delivery tool. The expandable member includes a proximal end that is free or slidably coupled to the delivery tool. The proximal end of the expandable member is configured to invert or slide toward a distal end of the expandable member, thereby causing the expandable member to surround at least a portion of the obstruction and the removal tool so that the obstruction is captured between the expandable member and the removal tool, when the delivery tool is withdrawn from the vasculature to remove the removal tool and the obstruction from the vasculature.

Abstract: The present teachings provide devices and methods of engaging, capturing, and retrieving emboli. Specifically, one aspect of the present teachings provides a device comprising a generally cylindrical body, with its proximal ends joining to a delivery system and a plurality of cells forming its luminal surface. The cylindrical body is configured to axially rotate as it radially expands. Another aspect of the present teachings provides a device comprising two elongated bodies one disposed within the other. As the device expands radially, both elongated bodies are configured to axially rotate independently.

Abstract: A medical extraction device comprising: (a) a sheath including a distal end configured to be inserted into a patient and a proximal end configured to be retained exteriorly of the patient; (b) a basket configured to extend from a distal end of the sheath and be repositionable between an expanded position and a retracted position, the basket including at least three loops, the basket also including a first guide and a second guide, where the first guide receives portions of the first loop and the third loop, where the second guide receives portions of the first loop and the second loop, where the second loop and the third loop are fixedly mounted to one another at a location interposing the first guide and the second guide; and, (c) a handle control operatively coupled to a proximal end of the sheath and being operatively coupled to the basket, the handle control configured facilitate repositioning of the basket with respect to the sheath between the retracted position and the expanded position.