Patents Examined by Katherine D Salmon
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Patent number: 11976336Abstract: A method of detecting the presence of Neisseria gonorrhoeae in a sample. The method involves detecting a first target sequence taken from the NGO1642 gene and/or a second target sequence taken from the NGO1012 gene. The method may involve a step of amplifying the target sequence, and may involve hybridising the target sequence to a nucleic acid probe and identifying hybridisation. The method may involve simultaneous detection of other target sequences, e.g. from other pathogens.Type: GrantFiled: January 28, 2022Date of Patent: May 7, 2024Assignee: Binx Health LimitedInventors: Danny Filer, Claire Ferrao, Sharon Chadwick
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Patent number: 11952623Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained from a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.Type: GrantFiled: September 2, 2021Date of Patent: April 9, 2024Assignee: VERINATA HEALTH, INC.Inventors: Stephen Quake, Richard P. Rava, Manjula Chinnappa, David A Comstock, Gabrielle Heilek
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Patent number: 11946106Abstract: In an aspect, the present disclosure provides a method for determining a methylation status comprises: providing a biological sample of nucleic acid molecules; partitioning at least a subset of the nucleic acid molecules in the biological sample based on the methylation status of the nucleic acid molecules into a plurality of partitioned sets; digesting at least a subset of the one or more partitioned sets in the plurality of partitioned sets with at least one methylation sensitive restriction enzyme; enriching at least a subset of the nucleic acid molecules in the plurality of partitioned sets for genomic regions of interest, wherein the at least a subset of the nucleic acid molecules comprises digested nucleic acid molecules in the one or more partitioned sets; and determining methylation status at one or more genetic loci of the nucleic acid molecules in at least one of the partitioned sets.Type: GrantFiled: December 22, 2022Date of Patent: April 2, 2024Assignee: Guardant Health, Inc.Inventors: Andrew Kennedy, William J. Greenleaf
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Patent number: 11939636Abstract: In an aspect, a method for detecting the presence or absence of cancer in a subject comprises: (a) obtaining samples from the subject from different time points, wherein a first sample obtained at first time point is a polynucleotide sample from a tumor tissue specimen and a second sample obtained at second time point is a cell-free polynucleotide sample from a blood sample; (b) processing polynucleotides from each of the samples, comprising: i) tagging at least a portion of the polynucleotides, thereby generating tagged parent polynucleotides; ii) amplifying at least a portion of the tagged parent polynucleotides to generate progeny polynucleotides; iii) enriching at least a portion of the progeny polynucleotides for target genomic regions; thereby generating enriched polynucleotides; and iv) sequencing at least a portion of the enriched polynucleotides to generate sequencing reads; and (c) analyzing genomic regions for at least one epigenetic feature from the sequencing reads.Type: GrantFiled: June 1, 2020Date of Patent: March 26, 2024Assignee: Guardant Health, Inc.Inventors: Ariel Jaimovich, Yupeng He, Oscar Westesson, William J. Greenleaf
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Patent number: 11906529Abstract: Methods and assays for diagnosis or prognosis of endometriosis include comparing an expression level or activity of miR-155 and JARID2 in a sample to detect a measurable difference. Therapeutic methods for treating endometriosis in a subject comprise identifying a subject as having a decreased expression level and/or activity of JARID2 in a sample obtained from the subject; and administering an agent that inhibits an activity of an miRNA that targets JARID2 or an agent that inhibits EZH2. Methods for screening for a compound useful for treating endometriosis are also provided and include contacting a cell with an effective amount of a test compound, and detecting whether the expression level or activity level of JARID2 or miR-155 in the cell is altered in the presence of the test compound.Type: GrantFiled: April 29, 2019Date of Patent: February 20, 2024Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventors: Nalini Santanam, Kristeena Ray Wright, Sarah Brunty
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Patent number: 11905565Abstract: This invention provides a kit or device for detection of prostate cancer and a method for detecting prostate cancer. This invention provides a kit or device for detection of prostate cancer comprising a nucleic acid capable of specifically binding to an miRNA in a sample from a subject or a complementary strand thereof and a method for detecting prostate cancer comprising measuring the miRNA in vitro.Type: GrantFiled: November 17, 2022Date of Patent: February 20, 2024Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Makiko Yoshimoto, Hiroko Sudo, Atsuko Miyano, Satoko Kozono, Takahiro Ochiya, Hiroyuki Fujimoto, Fumihiko Urabe, Juntaro Matsuzaki
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Patent number: 11884982Abstract: The present invention relates to the technical field of biology. Disclosed are a tumor marker, a methylation detection reagent, a kit and application thereof. Disclosed in the present invention is that: a colorectal cancer specimen can be distinguished from a fecal specimen of a normal person by detection a methylation level of COL4A1 gene promoter region. The present invention relates to detecting colorectal cancer by using the methylation detection reagent of the gene.Type: GrantFiled: May 5, 2019Date of Patent: January 30, 2024Assignee: CREATIVE BIOSCIENCES (GUANGZHOU) CO.Inventors: Xianglin Liu, Rongsong Zhao, Hongzhi Zou
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Patent number: 11884978Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.Type: GrantFiled: September 30, 2016Date of Patent: January 30, 2024Assignee: IMMUNEXPRESS PTY LTDInventors: Richard Bruce Brandon, Brian Andrew Fox, Leo Charles McHugh, Dayle Lorand Sampson
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Patent number: 11884985Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.Type: GrantFiled: January 11, 2022Date of Patent: January 30, 2024Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: David S. Perlin, Steven Park, David W. Denning
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Patent number: 11879159Abstract: The invention discloses a composition and kit for early detection of high-grade cervical lesions and cervical cancer, wherein the composition for early detection of high-grade cervical lesions and cervical cancer includes methylation primers, a probe corresponding to methylated sites and methylation blocking primers for FAM19A4 gene; methylation primers, a probe corresponding to methylated sites and methylation blocking primers for JAM3 gene; methylation primers, a probe corresponding to methylated sites and methylation blocking primers for PAX1 gene; and 1 pair of primers and a probe corresponding to methylated sites for internal reference gene GAPDH.Type: GrantFiled: October 11, 2022Date of Patent: January 23, 2024Assignee: BEIJING ORIGIN-POLY BIO-TEC CO., LTDInventor: Sijun Xiong
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Patent number: 11866790Abstract: The present invention discloses a combination of DNA methylation markers and the use thereof, primers, probes and a kit for early detection of ovarian cancer, wherein the combination of DNA methylation markers comprises at least one methylated fragment of each of four genes, including PCDHB18P, CDO1, HOXA9 and LYPD5. The detection primers and kit obtained for the methylated regions of the target genes can significantly improve the sensitivity of ovarian cancer detection, and meanwhile maintain a high specificity for normal ovarian cells and benign ovarian tumors. The detection primers and probes detect patients with possible gynecological malignant tumors early through molecular epigenetic methods using methylation detection technology, and the result is very accurate, and can provide clinicians with auxiliary diagnostic reference for early prophylactic treatment.Type: GrantFiled: July 22, 2022Date of Patent: January 9, 2024Assignee: BEIJING ORIGINPOLY BIO-TEC CO., LTDInventors: Pei Liu, Linhai Wang
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Patent number: 11860168Abstract: Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.Type: GrantFiled: August 29, 2019Date of Patent: January 2, 2024Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Adel Mohamed Talaat, Chia-wei Wu
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Patent number: 11851714Abstract: The present disclosure relates to a DNA methylation markers combination for bladder cancer risk stratification, which includes methylation regions as denoted by any one or more of SEQ ID NOS:1-22 or any one or more of complementary sequences thereof. The present disclosure further provides a clinical application of the three-class stratification mode before operation based on the selected appropriate molecular marker combinations, to promote the rational use of current diagnosis and treatment methods, consequently patients with negative BC can avoid excessive invasive cystoscopy, while HR-NMIBC or MIBC can expedite diagnosis and surgical operations, and the definite LMR-NMIBC patients can follow standard diagnostic modalities.Type: GrantFiled: September 29, 2020Date of Patent: December 26, 2023Assignee: AnchorDx Medical Co., Ltd.Inventors: Ruan Weimei, Jiang Zeyu, Li Xia, Chen Zhiwei, Fan Jianbing
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Patent number: 11845992Abstract: The present invention relates to compositions and methods for detecting CDK4/6 response and resistance.Type: GrantFiled: January 25, 2021Date of Patent: December 19, 2023Assignee: DANA-FARBER CANCER INSTITUTE, INC.Inventors: Liam Cornell, Geoffrey I. Shapiro
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Patent number: 11840733Abstract: The present invention relates to a method for predicting the prognosis of a breast cancer patient. More specifically, to provide information needed to predict the prognosis of a breast cancer patient, the method for predicting the prognosis of breast cancer including the following steps of the present invention comprises: (a) obtaining a biological sample from a breast cancer patient; (b) measuring the mRNA expression level of matrix metallopeptidase 11 (MMP11) and the mRNA expression level of cluster of differentiation 2 (CD2) from patient information or the sample of step (a); (c) normalizing the gene mRNA expression levels selected and measured in step (b); and (d) predicting the prognosis of breast cancer by combining the gene expression levels normalized in step (c), wherein overexpression of the MMP11 indicates a bad prognosis, and overexpression of CD2 indicates a good prognosis.Type: GrantFiled: November 21, 2017Date of Patent: December 12, 2023Assignee: GENCURIX INC.Inventors: Sang Rae Cho, Young Ho Moon, Jin Il Han, Young Kee Shin
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Patent number: 11840737Abstract: A process for analysing chromosome regions and interactions relating to immunoresponsiveness.Type: GrantFiled: November 2, 2018Date of Patent: December 12, 2023Assignee: OXFORD BIODYNAMICS PLCInventors: Alexandre Akoulitchev, Aroul Selvam Ramadass, Ewan Hunter
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Patent number: 11834715Abstract: Disclosed herein include systems, methods, compositions, and kits for quantitative analysis of a plurality of cellular component targets of cells of interest. In some embodiments, an oligonucleotide associated with a cellular component-binding reagent (e.g., an antibody) is associated with one or more detectable moieties (e.g., luminescent moieties, fluorescent moieties, a phosphorescent moieties). In some embodiments, the presence of the detectable moiety in the binding reagent oligonucleotide enables the cellular component-binding reagent to be employed for both fluorescence analysis (e.g., cell sorting) and sequence analysis (e.g., protein expression profiling).Type: GrantFiled: January 21, 2020Date of Patent: December 5, 2023Assignee: Becton, Dickinson and CompanyInventors: Margaret Nakamoto, Eleen Shum, Nidhanjali Bansal, Christina Chang
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Patent number: 11827927Abstract: The invention relates to a method of preparing and using a library of template polynucleotides suitable for use as templates in solid-phase nucleic acid amplification and sequencing reactions to determine the methylation status of the cytosine bases in the library. In particular, the invention relates to a method of preparing and analysing a library of template polynucleotides suitable for methylation analysis.Type: GrantFiled: February 17, 2021Date of Patent: November 28, 2023Assignees: ILLUMINA CAMBRIDGE LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Niall Gormley, Andreas Gnirke, David Jaffe, Harris Nusbaum
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Patent number: 11827939Abstract: The present invention relates to a method of diagnosing cholangiocarcinoma through bacterial metagenomic analysis, and more particularly to a method of diagnosing cholangiocarcinoma by analyzing an increase or decrease in content of specific bacteria-derived extracellular vesicles through bacterial metagenomic analysis using subject-derived samples. Extracellular vesicles secreted from bacteria present in the environment are absorbed into the body, and can directly affect the occurrence of cancer, and cholangiocarcinoma is difficult to diagnose early before symptoms appear so that effective treatment is difficult.Type: GrantFiled: January 18, 2019Date of Patent: November 28, 2023Assignee: MD HEALTHCARE INC.Inventor: Yoon-Keun Kim
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Patent number: 11821038Abstract: Disclosed herein is a method for the diagnosis/prognosis of a septic syndrome based on a biological sample from a patient. The method may include extracting biological material the biological sample, contacting the biological material with at least one specific reagent that is selected from specific reagents for the target genes having a nucleic acid sequence of any one of SEQ ID NOs: 1 to 28, and determining the expression of at least one of the target genes.Type: GrantFiled: March 12, 2021Date of Patent: November 21, 2023Assignee: BIOMERIEUXInventors: Alexandre Pachot, Guillaume Monneret, Alain Lepape