Abstract: In one aspect, a stent delivery system includes a catheter having two or more pullwire lumens evenly spaced about the central axis of the catheter and thereby balanced within the catheter. Pullwires are positioned in the pullwire lumens. Proximal portions of the pullwires are attached to a connector, which is attached to a master pullwire. The connector has a given range of motion that allows the pullwires to move within the pullwire lumens, thereby ensuring full flexibility of the catheter. The pullwires assume different lengths. A pullwire positioned over the outer curve of a flexed catheter may be longer than a pullwire positioned within the inner curve of the catheter, preventing the catheter from being straightened or displaced by the action of retracting the pullwires. The catheter may serve as either an inner member on which a stent is mounted or a sheath enclosing a stent.

Abstract: Leads for chronic implantation in the brain or other anatomical targets utilize tubular stylet means which are external to the lead. The lead comprises a distal electrode terminal, a proximal connector terminal, and a conductor cable having a reinforced distal portion and a stepped outside diameter providing a shoulder which cooperates with the distal end of the external stylet means. The substantial stiffness of the external stylet allows implantation of the lead without a brain-entering cannula. A tubular stylet spacer is employed to minimize lead dislodgement due to disassembly and removal of the lead introduction tools. Externalized stylet allows the conductor cable to have a small outside diameter and a desirably short length. A method of terminating conductors to electrodes using inserts is suitable for very fine wires and stranded conductors. A reinforced electrode terminal construction enables robust small-dimensioned terminal and high localization accuracy when introduced with external stylet means.

Abstract: A nipple simulating the shape, surface geometry and function of a woman's breast is provided. The nipple has a stem and a base. The base has an areola region and a bulbous region. The areola region is positioned between the stem and the bulbous region, and can simulate the areola of a woman's breast. The bulbous region can simulate the region of a woman's breast surrounding the areola. The areola region has a texture or surface geometry that is different from the texture or surface geometry of the stem or bulbous region.

Abstract: A drainage stent delivery system including an elongate shaft of a medical device, a drainage catheter or stent, and an engagement member, such as a distensible member or a compressible member, for selectively coupling the stent to the elongate shaft. The engagement member is positioned between the inner surface of the stent and the outer surface of the elongate shaft and is elongatable from a first length to a second length by longitudinal movement generally parallel to the central longitudinal axis of the stent to release the stent. At the first length, the engagement member is engaged with the inner surface of the stent to secure the stent on the elongate shaft, and at the second length the engagement member is sufficiently disengaged from the inner surface of the stent to release the stent from the elongate shaft such that the elongate shaft may be withdrawn from the stent.

Abstract: Ultrasound catheter devices and methods of the present invention generally provide for ablation and/or disruption of vascular occlusions. An ultrasound transmission member, such as a wire, transmits vibrational energy from an ultrasound transducer to a distal head of the catheter to disrupt vascular occlusions. An absorber member is disposed on or around the ultrasound transmission wire at a location adjacent the sonic connector of the catheter. The absorber member absorbs heat, vibrations, and/or the like from the ultrasound transmission wire at or near the area where the transmission wire is coupled with the sonic connector. The absorptive function typically slows the process of wear and tear on the transmission wire, thus extending the useful life of the ultrasound catheter.

Abstract: Apparatus and methods for delivering prosthetic segments to a body lumen, utilize a device having an elongated flexible member including proximal and distal ends, a plurality of prosthetic segments releasably arranged axially along the elongated flexible member near the distal end and an outer sheath slidably disposed over at least a portion of the prosthetic segments. The apparatus further includes a separator disposed on the outer sheath and adapted to engage the prosthetic segments. The separator is also adapted to be retracted proximally over the prosthetic segments and advanced distally to separate a proximal group of the prosthetic segments from a distal group of the prosthetic segments which are to be deployed in the body lumen.

Abstract: A tissue fixation system including a delivery tube and an elongated fastener with a loop at a proximal end and a distal end. A proximal end of an elongated curved needle is attached to the delivery tube. A distal end of the needle is configured to penetrate tissue. The needle includes an open channel sized to receive the elongated fastener with the loop located near the proximal end of the elongated curved needle and the distal end of the elongated fastener located near the distal end of the elongated curved needle. A capture needle is slidably positioned in the delivery tube to slide through the loop in the proximal end of the elongated fastener. The capture needle is configured to grasp the distal end of the elongated fastener and pull the distal end of the elongated fastener through the loop to cinch the elongated fastener.

Abstract: A collapsible medical device for use, e.g., as a vascular filter. The device includes a mandrel having a distal end and a stop spaced proximally of the distal end. A proximal length of the mandrel extends proximally of the stop and a distal length of the mandrel extends distally of the stop. A functional element (e.g., a vascular filter) has a radially expandable body and includes a proximal slider and a distal slider. The proximal and distal sliders are slidable along the mandrel independently of one another such that the distance between the proximal slider and distal slider can be varied to effect different configurations of the functional element. In one method of using such a device, the functional element is urged distally to a treatment site by urging the mandrel distally.

Abstract: Systems for controlling obesity utilize a number of space occupiers positioned in the stomach to reduce the effective volume of the stomach. Such arrangements provides sufficient stomach volume consumption to induce weight loss, but enable use of space occupiers that are proportioned to minimize the threat of obstruction even if they should migrate into the intestine. In general, numerous small volume space occupiers are placed in the stomach such that the total volume equals or exceeds the single volume of prior art single unit space occupiers. However, each individual space occupier is proportioned so that it will pass without obstruction if it moves into the intestine.

Abstract: A latch mechanism for a surgical instrument includes a lever moveable from an initial position to an actuated position for moving an end effector assembly from a first to a second state. A pin extends from the lever. A cantilever spring is operably engaged to the housing of the instrument. A pin track member is operably engaged to the cantilever spring at a free end thereof. The pin track member is configured to permit translation of the pin therealong between a first position corresponding to the initial position of the lever and a second position corresponding to the actuated position of the lever. The pin is configured to translate from the first to the second position along a first path and from the second position back to the first position along a second path and is configured to be releasably retained in the second position.

Abstract: A radiolucent fastening device for fastening a reference device to a body for computer-assisted surgery, wherein a part of the fastening device is made from an unsubstituted carbon fiber reinforced polyether compound, a monosubstituted carbon fiber reinforced polyether compound or a multisubstituted carbon fiber reinforced polyether compound.

Abstract: A medical treatment tool includes: an insert portion at least a part of which is provided by a flexing portion that is adapted to be flexed, the insert portion being adapted to be inserted into a human body of a patient; and an inflatable body provided on an outer circumference of the flexing portion, the inflatable body being inflated in a radial direction of the flexing portion. An axial distal end portion of the inflatable body is fixed to the insert portion while a proximal end portion of the inflatable body is axially movable relative to the insert portion.

Abstract: Spring clips are arranged end to end in a cavity of an inner shaft. Such shaft slides within an outer shaft, and a pusher member slides in the cavity behind the clips. The clips have jaws biased together, but which are wedged apart by an opener as the pusher is moved distally. An opened clip is ejected by relative movement of the inner and outer shafts to clamp body tissue at a desired site.

Abstract: Provided herein are a system and method for detaching a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. The system includes a bead disposed against a distal end of the therapeutic device that retains the therapeutic device to the delivery tube in a first compressed configuration through a series of connectors. The series of connectors include a stretch resistant member through which the bead is attached to an anchor inside the therapeutic device. The anchor, in turn, is disposed against a thermally responsive element comprised of a polymeric material configured to melt or otherwise change configuration to release the anchor, and with it, to also release the bead and therapeutic device. Energy may be supplied to the thermally responsive element through electrical conductors and a resistive heating element disposed within the delivery tube.

Abstract: An intracorporeal space filling device and a delivery system and method for using the device is disclosed. The space filling device is preferably configured for percutaneous delivery from a peripheral conduit of a patient. The space filling device has an elongated tubular or interconnected bead structure which may have a transmutable material disposed within it. The transmutable material can be altered from a non-rigid state to a rigid state by the application of various types of energy or by other suitable means. The space filling device can be positioned by a delivery system and detached from the delivery system after desired positioning is achieved.

Abstract: A vascular graft for anastomosis of blood vessels or ducts comprises piercing means (3) for engaging an end portion (8/8?) of a blood vessel or prosthesis and means (6, 6?) for precisely guiding one or more piercing elements (3) to pierce the wall of the vessel or prosthesis to a predetermined depth and in a predetermined direction.

Abstract: A fixation device includes a member defining at least two openings, and a suture tied to the member by passing the suture through the at least two openings in the member to form two suture loops through which ends of the suture pass. The two suture loops are interconnected. A method of securing a tissue graft includes providing the fixation member, attaching the suture to a tissue graft, and adjusting the length of the suture between the fixation member and the tissue graft by pulling the suture.

Abstract: An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.

Abstract: A surgical method of treating tissue within the body of a patient may include: providing an endocutter having a staple holder and a plurality of staples, where a plurality, but less than all, of the staples are arranged in a firing position within the staple holder; engaging tissue of the patient with the staple holder; deploying the plurality of staples in firing position through a buttress and into tissue of the patient; disengaging the end effector from tissue of the patient; moving a plurality of staples into firing position; engaging tissue of the patient with the staple holder; advancing a segment of buttress relative to the staple holder; and repeating the deploying.

Abstract: In order to provide a surgical instrument which is particularly simple to manipulate and enables force to be transmitted particularly directly to at least two tool elements wherein the surgical instrument comprises said at least two tool elements which are movable relative to one another and are arranged at a distal end of a guide device of a surgical instrument, and also comprises a force transmission device for transferring an actuating force from a proximal end of the force transmission device to a distal end of the force transmission device for the purposes of moving at least one of the at least two tool elements relative to the guide device, it is proposed that the surgical instrument should comprise a coupling device for selectively coupling the force transmission device directly or indirectly to at least one of the at least two tool elements.