Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, the image analysis system collects a surgical site image and indicates on a display one or more locations of the identified cancer cells. In some embodiments, the method for identifying residual cancer cells comprises determining and selecting a portion of the surgical site image responsive to an intensity parameter; modifying the selected portion of the surgical site image to determine one or more groups of residual cancer cells based on size; and identifying at least one of the one or more groups of residual cancer cells from the modified portion of the surgical site image using a local-based threshold.

Abstract: Apparatus and methods are described including tracking a tool portion and a patient marker from a first line of sight, using a first tracking device disposed upon a first head-mounted device that includes a display. The tool portion and the patient marker are tracked from a second line of sight, using a second tracking device. When a portion of the patient marker and the tool portion are both within the first line of sight, an augmented reality image is generated upon the first display based upon data received from the first tracking device and without using data from the second tracking device. When at least the patient marker portion and the tool portion are not both within the first line of sight, a virtual image of the tool and anatomy of the patient is generated using data received from the second tracking device. Other applications are also described.

Abstract: Methods, systems and computer program products for determining a property for a sample having a target region using ultrasound data from an ultrasound scanner include generating at least one spatial coherence curve based on ultrasound backscatter data in the target region, the spatial coherence curve comprising coherence values as a function of depth in the sample; and determining a property for a sample in response to the spatial coherence curve as a function of depth.

Abstract: An ultrasound phased array transducer is disclosed that achieves suppression of grating lobes through the incorporation of a coupling layer, where the coupling layer is positioned adjacent to the phased array transducer such that an ultrasound beam propagates through the coupling layer prior to encountering a propagation medium. The phased-array elements may be provided such that one or both of the array pitch and a lateral extent of each ultrasound transducer element is larger than half of the ultrasound wavelength in the propagation medium. Grating lobes within the coupling layer and the propagation medium may be reduced or suppressed by selecting a coupling material having a speed of sound that exceeds that of the propagation medium. The coupling layer may have a thickness sufficient for the generation of a wavefront, and the coupling layer may be formed from a viscous or viscoelastic material.

Abstract: A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.

Abstract: A multi-modality cancer screening and diagnosis system is provided that allows cancer screening and diagnosis of a patient using at least two different and sequential three-dimensional imaging techniques without patient repositioning. The system includes a first three-dimensional image acquisition device, a second three-dimensional image acquisition device having a probe with a transmitter mounted thereon, and a positioning paddle for positioning and immobilizing an object to be imaged during the cancer screening and diagnosis procedure. The positioning paddle is designed to facilitate visualization of the breast in both three-dimensional modalities without movement of the patient, and preferably is designed to position the patient with comfort during a diagnosis procedure which uses both imaging modalities.

Abstract: The present specification discloses a neuromodulation system comprising a transcranially mounted neuromodulation device and a stimulation control computing environment. The disclosed neuromodulation device comprising at least one ultrasound transducer and at least one EEG electrode and the disclosed stimulation control computing environment comprises a stimulation control unit and offline computing device, the disclosed stimulation control unit including associated systems and methods for controlling the neuromodulation device functionality using acoustic simulations performed on brain image data as well as methods and uses of such neuromodulation systems in modulating brain activity using focused ultrasound stimulation of the thalamus and thalamic sub regions during certain phases of slow wave brain oscillations in order to treat various neural-based disorders or conditions including sleep disorders.

Abstract: A method of reconstructing a shape of a volume of a part of a subject based on intrabody measurements of a plurality of crossing electromagnetic fields established within the volume, the method including: receiving, by computer circuitry, measurements of the crossing electromagnetic fields carried out using at least one sensor carried on an intrabody probe, the measuring being carried out with the probe at multiple locations in the volume, to provide a set of measurement samples, each taken at a location; generating, by computer circuitry and based on said measurement samples, a transformation that transforms measurement samples to geometric positions; transforming, using said generated transformation fewer than half of the measurements in said set of measurement samples into a set of geometric positions; and reconstructing the shape of said volume from said set of geometric positions.

Abstract: The present invention provides a system and method for performing a single-scan rest-stress cardiac measurement. In one aspect, the system includes a positron emission tomography (PET) imaging system, a source of a first PET radiotracer for administration to a subject, a source of a second PET radiotracer for administration to a subject, and a processor. The processor has non-transient computer readable media programmed with instructions to obtain PET images of the subject administered with the radiotracer. Furthermore, the computer readable media is programmed with instructions to process the PET images with a non-steady-state, multi-compartment parametric model. An output of the non-steady-state, multi-compartment parametric model is a measure of myocardial blood flow for both a rest state and a stress state of the subject.

Abstract: A method is disclosed for diagnosing and treating a patient having lesions in both arteries of left and right lower limbs. By determining that a lesion distal to an aortailiac bifurcation is to be treated first, catheters and an operation time can be reduced is to be treated first on a priority basis based on diagnostic data, deciding that a lesion proximal to the bifurcation is to be treated next, then treating the lesions substantially continuously.

Abstract: Motion independent acoustic radiation force impulse imaging is provided. Rather than rely on the displacement over time for each location, the displacements over locations for each time are used. Parallel beamforming is used to simultaneously sample across a region of interest. Since it may be assumed that the different locations are subjected to the same motion at the same time, finding a peak displacement over locations for each given time provides peak or profile information independent of the motion. The velocity or other viscoelastic parameter may be estimated from the displacements over locations.

Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

Abstract: Aspects of the technology described herein include determining, during ultrasound imaging, that an anatomical region is clipped by a field of view of an ultrasound image, and providing a notification, during the ultrasound imaging, that the anatomical region is clipped by the field of view of the ultrasound image. Aspects of the technology described herein also include determining that an anatomical region is clipped by a field of view of at least one ultrasound image collected during a three-dimensional ultrasound imaging sweep, and providing a notification that the anatomical region is clipped by the field of view of the at least one ultrasound image collected during the three-dimensional ultrasound imaging sweep.

Abstract: A tunable implant, system, and method enables a tunable implant to be adjusted within a patient. The tunable implant includes a securing mechanism to secure the implant in the patient, a actuation portion that enables the implant to move and an adjustment portion that permits adjustment of the implant after the implant has been positioned within the patient. The method of adjusting the tunable implant includes analyzing the operation of the implant, determining if any adjustments are necessary and adjusting the implant to improve implant performance. The implant system includes both the tunable implant and a telemetric system that is operable to telemetrically receive data from the tunable implant where the data is used to determine if adjustment of the tunable implant is necessary. The system also includes an instrument assembly that is used for performing spinal surgery where the instrument assembly includes a mounting platform and a jig.

Abstract: An ultrasonic imaging system produces more diagnostic cardiac images of the left ventricle by plotting the longitudinal medial axis of the chamber between the apex and mitral valve plane as a curved line evenly spaced between the opposite walls of the myocardium. Transverse image planes are positioned orthogonal to the curved medial axis with control points positioned in the short axis view on lines evenly spaced around and emanating from the medial axis. If the short axis view is of an oval shaped chamber the transverse image is stretched to give the heart a more rounded appearance resulting in better positioning of editing control points.

Abstract: Ultrasound beamformer-based channel data compression allows for software-based image formation. To increase the amount of data transferred, ultrasound beamformer-based channel data compression is provided. A beamformer is used to compress instead of or in addition to traditional beamformation. The compression reduces the data bandwidth while allowing reconstruction of the original channel data.

Abstract: A tunable implant, system, and method enables a tunable implant to be adjusted within a patient. The tunable implant includes a securing mechanism to secure the implant in the patient, a actuation portion that enables the implant to move and an adjustment portion that permits adjustment of the implant after the implant has been positioned within the patient. The method of adjusting the tunable implant includes analyzing the operation of the implant, determining if any adjustments are necessary and adjusting the implant to improve implant performance. The implant system includes both the tunable implant and a telemetric system that is operable to telemetrically receive data from the tunable implant where the data is used to determine if adjustment of the tunable implant is necessary. The system also includes an instrument assembly that is used for performing spinal surgery where the instrument assembly includes a mounting platform and a jig.

Abstract: Systems, apparatuses, methods, and non-transitory computer-readable media related to a tool for determining presence or absence of a neurological condition in a subject are provided. The tool includes an ultrasound device configured to collect ultrasound data from a head of the subject. The tool further includes a processing circuit configured to calculate a curvature metric based on the ultrasound data. The processing circuit is further configured to calculate a velocity asymmetry metric based on the ultrasound data. The tool is further configured to determine presence or absence of the neurological condition in the subject based on the curvature metric and the velocity asymmetry metric.

Abstract: For quantitative ultrasound imaging with a medical diagnostic ultrasound scanner, muscle tissue is scanned in order to determine the state of contraction. Once the desired state is identified, then QUS imaging is triggered to quantify or measure a tissue property while the muscle is in the desired state. The values of the tissue property at a known state of contraction may be more diagnostically useful or informative. Comparisons of the tissue property across time and/or location may more accurately reflect diagnostic information due to the triggering.

Abstract: The present disclosure is generally directed to a method for driving an ultrasonic transducer. The method includes coupling a driving electrode and a ground electrode of the ultrasonic transducer to a power supply and a ground, respectively, during a first time period based on a received drive signal. The method further includes decoupling the driving electrode and the ground electrode of the ultrasonic transducer from the power supply and the ground, respectively, to float the driving electrode and the ground electrode of the ultrasonic transducer during a second time period based on the received drive signal to store a charge between the driving electrode to the ground electrode.