Abstract: The present invention provides a wide-area sample-based reader design which serves as a diagnostic detection device for bio-particles.

Abstract: There is provided a nucleic acid extraction method using a cartridge comprising: (a) a driving part of a nucleic acid extraction device is connected to a control rod module disposed in an inner space of the upper body of a piston and a rotation control module coupled to the lower body of the piston; (b) driving the rotation control module and the control rod module, sequentially sucking sample and reagents from the plurality of chambers separated from each other into an interior space, and discharging the mixture of the interior space into the chamber of the cartridge; and (c) driving the rotation control module and the control rod module to suck the reagent inside the master mix bead chamber of the cartridge into the interior space of the piston upper body and then discharge the mixed reagent to a nucleic acid amplification module.

Abstract: Provided is a temperature control system applied to an apparatus for analyzing a sample using a pipette nozzle and a reaction container, including a pipette tip temperature controller that heats a pipette tip which is fitted on the pipette nozzle and aspirates or discharges liquid and a reaction container temperature controller that heats the reaction container. The pipette tip temperature controller heats, in a concentrated manner, at least a distal end portion of the pipette tip of the pipette nozzle located at a predetermined heating position with hot air emitted from a heat source and is configured such that a distal end is capable of arriving at the reaction container by lowering the pipette nozzle from the heating position.

Abstract: An arrangement is provided that is configured to measure a biomarker value of an animal milk sample, including a cassette including a carrier tape having test zones indicating the biomarker value, and an inspective window. The carrier tape is disposed on first and second spools configured to cooperate with a cassette external motor. The arrangement also includes a service module including a camera configured to inspect the test zone, a motor configured to be engaged with a cassette spool, and a tube element configured to provide the milk sample to the test zone.

Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.

Abstract: A device for locking a volume adjustment screw for a pipetting system, comprising a control member which rotates as one with a position selector, the member cooperating with a locking wheel such that: when the selector is in the free adjustment position, the member ensures that the wheel is axially spaced from another wheel, such that the teeth of the wheels do not cooperate with each other; when the selector is in the fine adjustment position, the member allows the wheel to move away from and then to move axially towards the other wheel while transitioning from one tooth to another; when the selector is in the locking position, the member axially locks the wheel to prevent the teeth from being disengaged.

Abstract: A pipette for use with a pipette tip includes a housing, a pin on the bottom end of the housing holding a pipette tip having first means for form-fit connection and a second means for form-fit connection which can be shoved onto the pin, constricting the pin, and/or expanding the tip before form-fit connection with the pin, a drive apparatus, at least one locking sleeve arranged concentric to the pin which is guided toward the pin in the housing, wherein the locking sleeve has a locked position having a pin in the inside constricted by shoving on a pipette tip, and/or is bordered on the outside by a tip shoved onto the pin, preventing a release from the pin, and the locking sleeve is upwardly displaceable out of the locked position so that the pin, and/or the tip is released, and the tip is removable from the pin.

Abstract: A medical analysis method uses a medical analysis machine provided with a poly-articulated robot (70) comprising joints defining at least six axes of rotation (A1, A2, A3, A4, A5, A6) and adapted for spacing and/or orienting a terminal member (66) according to six degrees of freedom, the terminal member bearing a grasping member (78) adapted for grasping a container (16). The medical analysis method comprises at least the succession of steps consisting of providing a container (16) containing a sample to be treated stemming from a human being or an animal, transferring said container (16) towards at least one treatment station of the medical analysis machine (100) by means of the poly-articulated robot, treating the sample in a treatment station, transferring the container towards a station for capturing images, and displaying the treatment results through a user interface.

Abstract: A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects.

Abstract: Aspects of the present disclosure relate to methods and devices for automatically transferring samples and/or reagents from sample vessels and/or reagent vessels into at least one receiving vessel In one example embodiment, a pipetting device is disclosed including a pipettor that is movable along a first direction and has at least one first pipetting needle that is movable along an arm of the pipettor along a second direction, substantially normal to the first direction. The pipetting needle is lowerable along a third direction into the individual vessels. In some specific embodiments, the arm of the movable pipettor has at least one second pipetting needle which, regardless of the current position of the first pipetting needle, is movable past the first pipetting needle and is lowerable into the individual vessels.

Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

Abstract: A microplate processing device having at least one carriage with a first receptacle for microplates where the at least one carriage is movable in a first horizontal direction, and having at least one lift that is movable in a vertical direction, where the microplates can be removed from and supplied to the carriage, the carriage has a through-opening, the periphery, in the vertical projection, can at least in part be situated horizontally within the periphery of a microplate held in the carriage, and the lift has a second receptacle for microplates, the periphery, in the vertical projection, is situated within the periphery of the through-opening, where the second receptacle can be moved unhindered through the through-opening in the vertical direction.

Abstract: The system includes a pipette tip with a proximal end that has a rim. The rim defines a proximal opening adapted to receive a pipetter, and the rim includes a rim conical edge. The system also has a support card with a top surface, a pipette tip receiver opening within the top surface, the opening adapted to receive the pipette tip and having a receiver opening conical edge. The rim conical edge and the receiver opening conical edge are constructed such that when the pipette tip is disposed of in the pipette tip receiver opening, the rim conical edge abuts the receiver opening conical edge, and the top surface is flush with or nearly flush with the rim.

Abstract: Double bag having a first compartment containing a composition to be distributed and a second compartment for receiving a used fluid, a first bag connector communicating with the first compartment and serving to empty the latter, and a second bag connector communicating with the second compartment and serving to fill the latter.

Abstract: A laboratory sample/specimen temperature control device, specifically a metal bead bath that has its metal bead temperature controlled by a continuous flow of air into the bed of beads that is heated or cooled by a Peltier device that the air flows over. This provides great thermal uniformity across the bed of beads and constantly monitors and regulates the heat or cooling input rather than utilizing an on/off modulation temperature input approach.

Abstract: A laboratory flask for use in association with a laboratory heating block, having: a flask body, wherein the flask body includes an upper portion, a lower portion, and a sidewall, wherein the sidewall of the flask body includes an inner surface, and an outer surface; a neck, wherein the neck includes an upper portion, a lower portion, and a sidewall, wherein the sidewall of the neck includes an inner surface, and an outer surface, and wherein the neck emanates contiguously from the flask body; and a reservoir, wherein the reservoir includes an upper portion, a lower portion, a bottom wall, and a sidewall, wherein the sidewall of the reservoir includes an inner surface, and an outer surface, and wherein the reservoir is adapted for releasable securement within a laboratory heating block.

Abstract: The present invention relates to a separable cassette for measuring glycated hemoglobin. It is easy to use the separable cassette for measuring glycated hemoglobin of the present invention since a reagent is sequentially leaked during the rotation thereof. In addition, there is no need to shake the reagent beforehand, as the reagent without residual reagent is fully discharged by the rotation. Therefore, the measurement result is accurate because an error between the amount of the reagent used and the amount of sample blood is small.

Abstract: Systems and methods for handling a variety of sample and preparatory fluids in a rack specifically configured for compatibility with predetermined liquid handlers such as automated pipettors or multi-channel manual pipettors and set up for magnetic based sample preparation. The rack can hold all of the necessary sample and reagent vials, and present them to the pipettor in some embodiments in a way that allows for parallel operation. The rack includes slidable magnets that in some embodiments are actuatable directly by the pipettor, eliminating a layer of complexity. Combined with a suitable pipettor the magnet enabled rack supports a multistep magnetic based sample preparation capability in a high throughput manner at one station that enhances sample purity throughout magnetic separation processes.

Abstract: Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot.

Abstract: The disclosure provides a system and method to safely and efficiently store and transport process tubes in a carrier tray comprising prior to and during amplification of nucleotides in the process tubes. The process tube disclosed includes a securement region having an annular ledge, a neck, and a protrusion. The securement region of the process tube can secure the process tube in a port of the carrier tray, but still allows the process tube to adjust or float in order to align the process tube into a rigid heater well of a thermal cycler.