Abstract: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.
Type:
Grant
Filed:
November 12, 2004
Date of Patent:
July 17, 2007
Assignee:
Rice University
Inventors:
Ka-Yiu San, George N. Bennett, Henry Lin
Abstract: Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating type 2 diabetes, and methods for altering the ratio of MHCI to MHCII in a subject.
Type:
Grant
Filed:
October 29, 2004
Date of Patent:
June 26, 2007
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
K. Sreekumaran Nair, Laura J. Greenlund
Abstract: The present invention is directed toward a transgenic non-human animal and uses thereof, wherein each of the cells of the animal contain a transgene comprising a nucleic acid sequence encoding CD200.