Abstract: According to an embodiment of a method for providing neural stimulation, activity is sensed, and neural stimulation is automatically controlled based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise.
Abstract: Techniques are provided for controlling the recording of intracardiac electrograms (IEGMs) within an implantable medical device such as a pacemaker, wherein the device is capable of recording different channels of IEGMs in response to different diagnostic triggers. Exemplary triggers include pacemaker-mediated tachycardia; atrial tachycardia, atrial fibrillation, ventricular tachycardia, etc. In one example, the device stores, for each diagnostic trigger, a physician selection of particular IEGMs to be recorded for subsequent review. Then, whenever a trigger is detected, the device senses and records only the particular IEGMs that had been selected by the physician for that particular trigger. The IEGMs are eventually transmitted to an external programmer for review. In this manner, the physician can specify particular IEGMs to be stored in response to particular diagnostic triggers, thereby providing considerable diagnostic flexibility, while also conserving memory.
Abstract: A method and apparatus for determining oversensing of cardiac signals that includes a housing containing electronic circuitry, an electrode coupled to the electronic circuitry to sense cardiac signals, and a processor, positioned within the housing, to determine an oversensing characteristic associated with the cardiac signals sensed over a predetermined sensing window, and to identify oversensing in response to the determined oversensing characteristic.
Type:
Grant
Filed:
May 1, 2007
Date of Patent:
August 10, 2010
Assignee:
Medtronic, Inc.
Inventors:
Raja N. Ghanem, Robert W. Stadler, Xusheng Zhang, Karen J. Kleckner, Paul G. Krause
Abstract: Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, is provided to attenuate an immune response, including an inflammatory immune response. Devices such as pulse generators and drug pumps may be used to stimulate the sympathetic nervous system to attenuate an immune response. Systems optionally having one or more sensors and operator instructions may also be used. In specific examples, stimulation of the splenic nerve of pigs with a pulse generator is shown to be safe and effective in attenuating a lipopolysaccharide-induced immune response.
Abstract: The present invention relates in general to methodologies for the treatment quenching preconditioning and communication between the intrinsic cardiac nervous system and an electrical stimulus. In particular, the present invention utilizes spinal cord stimulation to alter and/or affect the intrinsic cardiac nervous system and thereby protect the myocytes, stabilize myocardial electrical instability and/or alleviate or diminish cardiac pathologies.
Type:
Grant
Filed:
November 3, 2005
Date of Patent:
August 3, 2010
Assignee:
The Board of Regents of the University of Oklahoma
Inventors:
Robert D. Foreman, Jeffrey L. Ardell, John A. Armour, Michael J. L. DeJongste, Bengt G. S. Linderoth
Abstract: A medical electrical lead configured for use in stimulating the left side of the heart (i.e., the left ventricle). In one embodiment, the lead includes an elongate lead body including an inner surface. An inflatable member is disposed on the outer surface of the body between its proximal and distal ends, the inflatable member being adapted when inflated to impart a radial force on and frictionally engage a surface of the coronary sinus or coronary vein for fixation of the distal end of the lead therein. The lead further includes a conductive member extending from the proximal end toward the distal end, and an inner insulating layer positioned between the conductive member and the inner surface of the body. Separation between the inner insulating layer and the inner surface of the body defines an inflation lumen in fluid communication with the inflatable member.
Type:
Grant
Filed:
January 12, 2007
Date of Patent:
July 27, 2010
Assignee:
Cardiac Pacemakers, Inc.
Inventors:
Eric T. Johnson, Brian D. Soltis, Bruce A. Tockman, Peter J. D'aquanni, Kent C. B. Stalker, Gayla A. Smith
Abstract: A method of promoting the healing of a lesion in a smooth muscle (200), comprises selecting a smooth muscle portion having a lesion, and applying a non-excitory electric field (210) to the portion, which reduces the mechanical activity of the portion.
Abstract: A blood pumping system to support living organisms based on a spherical multi vane and multi chamber pump with an oscillating motion that delivers pulsatile flow. The blood pumping system includes a number of design elements that address the particular needs and compatibility issues (both biological and hemological) of a blood pumping system.
Abstract: A method of and a device for non-invasively measuring the hemodynamic state of a subject or a human patient involve steps and units of non-invasively or minimally invasively measuring cardiac cycle period, mean arterial pressure, stroke volume, diastolic interval and ejection interval and converting the measured mean arterial pressure, stroke volume, diastolic interval and ejection interval into the cardiac parameters such as Preload, Afterload and Contractility, which are the common cardiac parameters used by an anesthesiologist. In the current invention, the use of electrical-mechanical interval has been eliminated for various advantageous reasons. The converted hemodynamic state of a patient is displayed on a screen as a three-dimensional vector with each of its three coordinates respectively representing Preload, Afterload and Contractility. Therefore, a medical practitioner looks at the screen and—quickly obtains the important and necessary information.
Abstract: A method and device for delivering anti-tachycardia pacing (ATP) therapy that includes an electrode to sense cardiac signals and to deliver the therapy, sensing circuitry, electrically coupled to the electrode, to detect the tachycardia event in response to the sensed cardiac signals, and a processor to control delivery of the therapy. The processor determines a cause of the delivered first plurality of pacing pulses failing to terminate the tachycardia event as a result of one of a failure to capture the tachycardia event, a failure to complete peelback, and a failure to entrain a reentrant circuit associated with the tachycardia event, and adjusts delivery of a second plurality of pacing pulses subsequent to the delivery of the first plurality of pacing pulses in response to the determined cause.
Abstract: Actuator mechanisms on the heart are of several types. In preferred embodiments, they are generally simple, durable, mechanical assemblies and are driven by power delivered from a remote location, generally outside the chest, by a variety of mechanisms. The invention teaches physical mechanisms (1) for transfer of cyclic power from outside the chest to the region of the heart for that purpose, either as translational or rotary motion. Also taught are electromechanical converting mechanisms suitable for delivering power to those transfer devices. The embodiments described herein for either transmission of energy from a site of generation to a conduit (2, 10, 22), and of conduits that then deliver energy to heart actuators, have contours and interfaces designed to promote a favorable biologic response similar to the pseudosynovial capsules that surround artificial joints. Further, design features are chosen to avoid both non-vented gas-filled chambers and static collections of tissue fluid.
Abstract: The invention provides a multichannel electrode (“MC electrode”) which can perform multiple functions such as recording, stimulating and lesioning simultaneously or sequentially upon a single insertion into a target site. In one aspect, the MC electrode further provides imaging and drug delivery capabilities. The invention also provides interface connectors for connecting the MC electrode to external units such as data acquisition and/or stimulation systems. Although the MC electrode and associated connectors and system(s) provide an optimal way to perform deep brain surgical procedures, the MC electrode and associated connectors and system(s) are useful generally in any technique which relies on recording, activating, and/or inhibiting electrical signals produced by cells.
Type:
Grant
Filed:
October 6, 2005
Date of Patent:
July 13, 2010
Assignees:
London Health Sciences Center, National Research Council of Canada
Abstract: An implantable system applies tiered antitachycardia pacing (ATP) that may be combined with pre-pulsing therapy in order to reduce pain. In one implementation, an exemplary system applies a progression of increasingly potent pacing vectors, progressing in an initial tier from small electrodes inside the heart to later tiers that increasingly use a large electrode surface outside the heart. In the latter tiers, a pre-pulse may be added prior to each ATP pulse to reduce the sensation of pain.
Type:
Grant
Filed:
April 28, 2006
Date of Patent:
July 6, 2010
Assignee:
Pacesetter, Inc.
Inventors:
Mark W. Kroll, Michael Benser, Euljoon Park
Abstract: An apparatus for measuring cardiac electrical activity of a patient includes: a malleable pad, a first electrocardiogram electrode, and a ground electrode. The pad includes: a right handle for grasping with the patient's right hand, the right handle including an electrocardiogram electrode; a left handle for grasping with the patient's left hand, the left handle also including an electrocardiogram electrode; and an electronic circuit configured for receiving electrical signals from the electrodes and also configured to invert the signals from the electrodes for transmission to a processor to produce a graphic recording of the differences in electrical potential between the electrodes. The pad also includes a multiplex cable for coupling the electronic circuit to leadwires attached to the electrocardiogram electrodes; and a port configured for coupling with the processor.
Abstract: Methods and devices for treating bronchial constriction related to asthma and anaphylaxis wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve and/or the lungs of a patient suffering from bronchial constriction.
Type:
Grant
Filed:
November 1, 2006
Date of Patent:
June 29, 2010
Assignee:
ElectroCore LLC
Inventors:
Joseph P. Errico, James R. Pastena, Steven Mendez, Hecheng Hu, Arthur Ross
Abstract: A gastro-electric stimulation system includes an INS for producing an electrical stimulation signal, at least one medical electrical lead, and at least two electrical contacts. The medical electrical lead has a proximal end and a distal end, the proximal end being connected to the INS and the distal end being adapted for placement in or near a patient's stomach or appropriate nerve or nerve portion. The electrodes are disposed near the distal end of the medical electrical lead, and the electrodes are electrically connected through the medical electrical lead to the INS to receive the electrical stimulation signal and convey such signal to the selected electrode implant position. The electrical stimulation signal is provided in an amount and manner adapted to decrease the pH of the gastric acid in the patient's stomach and/or to increase the amount of gastric acid produced thereby.
Type:
Grant
Filed:
May 19, 2003
Date of Patent:
June 22, 2010
Assignee:
Medtronic, Inc.
Inventors:
David A. Dinsmoor, Warren L. Starkebaum
Abstract: A medical electrode, and a method of making a medical electrode. The electrode comprises an electrode member having a top face and a bottom face; disconnected regions of electrically conductive material in electrical contact with the top face of the electrode member, patient contacting layer and an electrical connector in electrical contact with the disconnected regions. The disconnected regions reduce patient skin irritation and burning while optimizing electrical impedance of the electrode.
Type:
Grant
Filed:
September 29, 2006
Date of Patent:
June 22, 2010
Assignee:
Tyco Healthcare Group LP
Inventors:
Peter Gadsby, Peter F. Meyer, Scott Coggins
Abstract: A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an assessment of cardiac function in order to balance the beneficial effects of stress reduction with hemodynamic compromise.
Type:
Grant
Filed:
March 13, 2006
Date of Patent:
June 22, 2010
Assignee:
Cardiac Pacemakers, Inc.
Inventors:
Joseph M. Pastore, Rodney W. Salo, Jesse W. Hartley, Andrew P. Kramer, Jeffrey E. Stahmann
Abstract: A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.
Type:
Grant
Filed:
November 3, 2005
Date of Patent:
June 15, 2010
Assignee:
Cardiac Pacemakers, Inc.
Inventors:
Julio C. Spinelli, Qingsheng Zhu, Jeffrey E. Stahmann, Andrew P. Kramer
Abstract: Methods include determining whether an infection is in proximity to an implanted rechargeable medical device. If an infection is determined to be present, the recharge process is allowed to sufficiently heat the device to facilitate clearing of the infection. Additional methods include monitoring temperature in proximity to an implantable rechargeable device in connection with recharging the device. If the monitored temperature falls outside a desired range, one or more parameters associated with recharge energy are modified to cause the temperature to reside within the desired range. The desired temperature range, may be a range that can facilitate treatment of a condition in proximity to the implanted device without causing undesired damage to the patient's tissue surrounding the implanted device.