Patents Examined by Kenneth R. Hoblick
  • Detection as chromosomal translocations by extending and ligating differentially-labeled probes Hybridized on different sides of a break-point
    Patent number: 5922543
    Abstract: A composition and method of producing a composition which is directed to a single nucleic acid comprising a first section complementary to a sequence of a first chromosome, and comprising at least a first label, and a second nucleic acid section complementary to a sequence of a second chromosome, the second label being different from the first label. It is used for detecting translocations such that the single nucleic acid probe has different interactive labels on each side of a translocation break-point region.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: July 13, 1999
    Assignee: Universitat Heidelberg
    Inventor: Christoph Cremer