Abstract: Syntheses of compounds of Formula III from compounds of Formula I via compounds of Formula II are described, as well as particular compounds of Formula III, or pharmaceutically acceptable salts thereof, compositions comprising such compounds, and uses thereof. For example, certain of these compounds and compositions of Formula III have uses in the treatment of psychiatric or neurological disorders.
Type:
Grant
Filed:
August 26, 2021
Date of Patent:
May 9, 2023
Assignee:
Small Pharma Ltd
Inventors:
Peter Rands, George Knight, Richard Chubb, Derek Londesbrough, Tiffanie Benway, Zelah Joel
Abstract: Benzoxazine compounds, methods of making them, polymers made therefrom and methods of polymerizing the benzoxazines. These renewable benzoxazine monomers and polymers that utilize the variety of building blocks found in renewable plant biomass, demonstrate excellent processability and large temperature windows for processing of resin systems.
Type:
Grant
Filed:
August 21, 2018
Date of Patent:
May 9, 2023
Assignees:
Drexel University, The Government of the United States of America, as represented by The Secretary of the Army
Inventors:
Giuseppe R. Palmese, Santosh K. Yadav, John J. LaScala
Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, X, Y, Z, W, and m are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
Type:
Grant
Filed:
August 16, 2022
Date of Patent:
May 9, 2023
Inventors:
Robert B. Perni, Glenn Short, Srinivas G. Rao, Tanweer A. Khan
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
Type:
Grant
Filed:
December 7, 2021
Date of Patent:
May 9, 2023
Assignee:
ASTEX THERAPEUTICS LIMITED
Inventors:
Gianni Chessari, Christopher Norbert Johnson, Steven Howard, James Edward Harvey Day, Ildiko Maria Buck, Charlotte Mary Griffiths-Jones, Gordon Saxty, Emiliano Tamanini, Nicola Elizabeth Wilsher
Abstract: Absorbent articles comprising a multilayer outer cover comprising a first outer layer and a second outer layer comprising a component that exhibits at least partial elastic recovery after mechanical activation in the machine direction; an inner layer, disposed between the first outer layer and the second outer layer, the inner layer comprising elastic strands; and wherein at least one of the first outer layer and second outer layer is laminated to the inner layer.
Type:
Grant
Filed:
October 23, 2019
Date of Patent:
April 25, 2023
Assignee:
The Procter & Gamble Company
Inventors:
Jean-Philippe Marie Autran, Urmish Popatlal Dalal
Abstract: A wound dressing and a monitor device is disclosed, the wound dressing comprising a top layer; a first adhesive layer with a proximal surface configured for attachment of the wound dressing to the skin surface of a user; an absorbent core layer; an electrode assembly comprising a plurality of electrodes arranged on a distal side of the absorbent core layer; and a monitor interface configured for connecting the wound dressing to a monitor device, the monitor interface comprising a plurality of terminals configured to form electrical connections with respective terminals of the monitor device, wherein the wound dressing comprises a flexible element, the flexible element being bendable and/or twistable between a first flexible element end and a second flexible element end, and wherein the monitor interface comprises a coupling part positioned at the first flexible element end.
Type:
Grant
Filed:
June 14, 2019
Date of Patent:
April 25, 2023
Assignee:
Coloplast A/S
Inventors:
Jais Ask Hansen, Lars Erup Larsen, Niels Hvid, Mads Hindhede Svanegaard, Stephanie Knoedler
Abstract: The present invention generally relates to an absorbent component (100) for use in a garment. The absorbent component (100) comprises: a first layer composite (120) comprising a first foam layer (122) and a first liquid impermeable layer (124); an absorbent layer composite (140) bonded to the first liquid impermeable layer (124) for absorbing bodily fluids; and a second liquid impermeable layer (164) bonded to the absorbent layer composite (140) and first layer composite (120) to contain the bodily fluids absorbed by the absorbent layer composite (140), wherein the second liquid impermeable layer (164) forms an opening (166) for receiving the bodily fluids to the absorbent layer composite (140); and wherein the first foam layer (122) is moulded to shape the absorbent component (100).
Abstract: An endoscope surgery device includes a vibration unit and a surgery unit. The vibration unit generates a vibration. The surgery unit includes a sheath and a surgery member. The sheath has a tube shape with a hollow extended in a longitudinal direction, and is entirely vibrated due to the vibration from the vibration unit with inserted into the ureter. The surgery unit passes through the hollow of the sheath, and is extended to an end of the sheath for an surgical procedures on the ureter.
Type:
Grant
Filed:
September 18, 2019
Date of Patent:
April 18, 2023
Assignee:
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY
Inventors:
No Cheol Park, Kyo Chul Koo, Dongwook Kim
Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Type:
Grant
Filed:
August 11, 2022
Date of Patent:
April 18, 2023
Assignee:
Compass Pathfinder Limited
Inventors:
Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
Abstract: The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.
Abstract: A sanitary pad system includes a first pad and a second pad. The first pad has a first set of fastening tabs and the second pad has a second set of fastening tabs. The two sets of fastening tabs are offset so that, when the two pads are stacked in overlapping relationship on an undergarment, both pads are directly attached to the undergarment with the associated fastening tabs.
Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
Type:
Grant
Filed:
June 13, 2018
Date of Patent:
March 28, 2023
Assignee:
Kadmon Corporation, LLC
Inventors:
Eduardas Skucas, Kevin G. Liu, Ji-In Kim, Masha V. Poyurovsky, Rigen Mo
Abstract: A waist portion W has a first portion P1 and a second portion P2 each including a waist elastic member. The first portion P1 includes an over sheet layer folded back at an edge of a waist opening WO extending to an inside of a waist inner sheet layer. The over sheet layer is formed of a sheet material having a portion folded back at an edge of the waist opening WO from a position outside the waist elastic member in the second portion P2 and extending to a position inside the waist elastic member in the second portion P2. In the first portion P1, the waist elastic member is not fixed to the sheet material. In the second portion P2, the waist elastic member is fixed to the sheet material, and the sheet material is contracted in a width direction WD together with the waist elastic member.
Abstract: A medical device (10) configured for attachment to skin of a patient includes a vital sign sensor or drug delivery patch (14); and a plurality of suction cells (12) arranged around a periphery of the vital sign sensor or drug delivery patch.
Type:
Grant
Filed:
May 17, 2019
Date of Patent:
March 28, 2023
Assignee:
Koninklijke Philips N.V.
Inventors:
Igor Wilheimus Franciscus Paulussen, Rick Bezemer
Abstract: A disposable absorbent underwear product includes a garment layer, an absorbent insert, a non-woven patch, and a barrier. The absorbent insert has a fluid-impermeable base layer, an absorbent core, and a fluid-permeable top layer. The non-woven patch covers an end of the absorbent insert. A first portion of the non-woven patch is adhered to both the fluid-permeable top layer of the absorbent insert and the garment layer with an adhesive. A second portion of the non-woven patch is free and forms a pouch. An end portion of the absorbent core is disposed adjacent to the second portion of the non-woven patch. The barrier extends along a width of the absorbent insert. The barrier extends through the fluid-permeable top layer of the absorbent core and connects the fluid-impermeable base layer and the one non-woven patch to direct fluid flow to the absorbent core and militate against fluid overflow.
Abstract: The present disclosure is directed, in part, to an absorbent article comprising a liquid management system (LMS) and an absorbent core disposed at least partially intermediate a topsheet and a backsheet. The LMS defines one or more channels therein. The one or more channels of the LMS may at least partially overlap or not overlap with channels defined in the absorbent core.
Type:
Grant
Filed:
July 7, 2020
Date of Patent:
March 28, 2023
Assignee:
The Procter & Gamble Company
Inventors:
Donald Carroll Roe, Kathy Quinlan Ames-Ooten, Blanca Arizti, Julia Boesel, Aniruddha Chatterjee, Nelson Edward Greening, II, Sharon Irene Grenberg, Carsten Heinrich Kreuzer, Cornelia Beate Martynus, Marie Brigid O'Reilly, Rodrigo Rosati, Sandra Sautter, Beate Simon, Lutz Stelzig, Rachael Eden Walther
Abstract: A diaper changing pad and a cover for a diaper changing pad is provided. The diaper changing pad or diaper changing pad cover includes at least one region on its top surface that has male mechanical fastening structures that allow a clean diaper to be positioned in an open configuration, ready to be used in a diaper changing routine.
Abstract: Absorbent structures for absorbent articles are provided. The absorbent structure includes an absorbent layer with absorbent material supported by a supporting sheet, and a channel that is free of said absorbent material. The channel has a wet integrity of at least 20%.
Type:
Grant
Filed:
August 15, 2019
Date of Patent:
March 14, 2023
Assignee:
THE PROCTER & GAMBLE COMPANY
Inventors:
Rodrigo Rosati, Carsten Heinrich Kreuzer, Hans Adolf Jackels, Blanca Arizti, Ernesto G Bianchi, Donald Carroll Roe
Abstract: Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a negative pressure source, a sensor, and a controller. The negative pressure source can provide negative pressure via a fluid flow path to the wound dressing. The sensor can monitor pressure in the fluid flow path. The controller can determine whether the wound dressing is coupled to a wound from a change in magnitude of pressure in the fluid flow path over time being more indicative of a steady state condition than a chaotic condition while the negative pressure source maintains negative pressure in the fluid flow path within a pressure range. In addition, the controller can output a first indication denoting that the wound dressing is coupled to the wound and a second indication denoting that the wound dressing is not coupled to the wound.