Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Abstract: The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

Abstract: The present invention provides a novel chemical process for the synthesis of the compound N-[4-(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxpyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: A vehicle seat longitudinal adjuster (106) includes a seat track pair (1) with a lower seat track (2) and an upper seat track (4) that mutually engage one another for guided relative and longitudinal direction (x) movement. The lower seat track (2) has a substantially C-shaped profile (20, 22) with sections (24) that are bent downward at the ends. The upper seat track (4) has a substantially U-shaped profile (40, 42) with end sections (44) that are bent upward; the relative displaceability of the two seat tracks (2, 4) with respect to one another is limited by means of an interaction of an end stop (30) disposed on the lower seat track (2) with a stop element (48) disposed on the upper seat track (4), and wherein the end stop (30) is designed in the form of an extension of part of the downward bent sections (24) and the lower seat track (2) comprises a slotted hole (32) in the region of the end stop (30).

Abstract: The present invention is directed to 6,5-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A hanging system and a method of hanging a support structure from a support surface. The hanging system may include a support structure and a hanging bracket for hanging the support structure from a support surface such as a wall. The support structure may include a mounting groove that accepts a portion of the hanging bracket to facilitate the coupling therebetween. The support structure may be able to slide side-to-side along the support surface while remaining coupled to the hanging bracket. The hanging system may alternatively, or additionally, include a reinforcement bracket. The reinforcement bracket may serve the dual purpose of holding the various mitered components of the support structure together and facilitating the hanging of the support structure from the support surface.

Abstract: An exhaust line element includes an exhaust volume comprising a metal enclosure with a thickness smaller than 1 mm and at least one metal plate with a thickness comprised between 0.5 and 5 mm. The metal plate comprises a central part that does not contact the metal enclosure and between 2 and 4 fastening tabs are secured to the central part. Each fastening tab is spot and transparently welded to the metal enclosure.

Abstract: A clamp assembly is provided for securing a panel or fairing to an I-beam, and comprises a pair of side blocks and a clamping block having a central body and a flat surface at at least one end of the central body. The side blocks and the clamping block are secured together using a single bolt. The flat surface at the end of the central body is positioned at an angle to the central body, so as to provide an angled surface for mounting of a fairing.

Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.

Abstract: The present invention provides a horizontal instrument, a supporting device and a method for adjusting the bearing surface of the supporting device to be horizontal. The horizontal instrument in the present invention is used for maintaining a bearing surface parallel to a horizontal plane, wherein the horizontal instrument comprises a slide-swing assembly, and a monitoring assembly, when the monitoring assembly detects that the bearing surface is not parallel to the horizontal plane, the controller instructs the driving unit to drive the slider to slide, which leads the lower end of the swinging rod to slide, and then drives the swinging rod to swing, thereby, the upper end of the swinging rod drives the bearing surface to rotate for an angle so that the bearing surface is maintained parallel to the horizontal plane.

Abstract: The present invention provides for novel co-crystals of lenalidomide. The present invention particularly provides for novel cocrystals of lenalidomide with Resorcinol, Methyl paraben and Saccharin. The present invention also provides for the processes for the production of cocrystals of lenalidomide with Resorcinol, Methyl paraben and Saccharin. The present invention further provides for processes for the preparation of crystalline anhydrous lenalidomide Form IV.

Abstract: A method for preparing a tyrosine kinase inhibitor and a derivative thereof are described. In particular, the present method has a short synthesis route, low costs, easy operation, and is suitable for large-scale production.

Abstract: The present disclosure provides compounds represented by Formula I-A: A1-L1-B1 I-A and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein A1, B1, and L1 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a condition or disorder responsive to degradation of MDM2 protein such as cancer.

Abstract: The present invention relates to a co-crystal of roxadustat with L-proline and to a process for its preparation. Furthermore, the invention relates to a pharmaceutical composition comprising said roxadustat L-proline co-crystal, at least one pharmaceutically acceptable excipient and optionally at least one photostabilizing agent. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prevention of anemia in patients with end-stage renal disease (ESRD) and/or chronic kidney disease (CKD).

Abstract: The present disclosure relates to salts and crystalline forms of a compound having the formula (I): Also described are processes for the production of the salts and crystalline forms described herein.

Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Abstract: A gutter hanger includes a main body; a rear clip at a first end of the main body; a front hook at a second end of the body; at least one guide tab extending from the main body, the at least one guide tab sized and positioned to align a drive tool relative to the main body.

Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.